GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Methyltransf_33 - Histidine-specific methyltransferase SAM-dependent
Pfam: PF10017 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 127
Sequences: 668
Seq/Len: 5.26
HH_delta: 0.89 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
65_A69_Q0.59163.789
52_Y57_G0.441082.825
34_N41_F0.394912.529
45_D67_R0.385382.468
10_K122_D0.371832.381
5_C57_G0.356722.284
32_R36_E0.35322.262
2_V101_F0.329042.107
47_E66_K0.30121.929
58_R94_Y0.288981.851
62_Y87_R0.288471.847
89_H92_N0.270271.731
57_G100_E0.263451.687
45_D69_Q0.260121.666
98_P115_R0.259611.663
8_P54_P0.25861.656
41_F71_V0.256291.641
22_T91_E0.251681.612
49_V64_V0.245361.571
26_N90_T0.237531.521
68_D84_E0.235281.507
12_E16_N0.23451.502
3_D6_K0.232351.488
64_V87_R0.231351.482
71_V82_F0.227231.455
47_E64_V0.225991.447
68_D83_K0.22571.445
31_R43_P0.221871.421
26_N48_H0.221761.420
70_T81_H0.220921.415
5_C97_S0.216871.389
53_N60_E0.216191.384
30_L41_F0.214381.373
112_V126_Y0.210761.350
62_Y89_H0.206281.321
50_A61_M0.20161.291
5_C100_E0.197981.268
17_D22_T0.195371.251
22_T26_N0.194791.247
73_I80_I0.193751.241
17_D91_E0.19081.222
2_V126_Y0.190031.217
61_M90_T0.184361.181
42_D45_D0.180891.158
26_N61_M0.180641.157
38_G74_G0.176091.128
101_F126_Y0.173741.113
97_S100_E0.17321.109
53_N56_E0.172771.106
105_A126_Y0.17271.106
98_P124_S0.172561.105
8_P12_E0.172511.105
68_D81_H0.168651.080
106_E114_K0.167461.072
72_R79_T0.166481.066
33_A46_F0.165931.063
58_R62_Y0.164711.055
7_D13_A0.163541.047
57_G97_S0.162321.040
4_L117_T0.161891.037
17_D20_G0.161681.035
40_D72_R0.16151.034
110_L127_L0.159841.024
16_N52_Y0.158911.018
12_E52_Y0.157611.009
10_K13_A0.157161.006
36_E46_F0.156751.004
22_T48_H0.154620.990
9_E121_G0.151260.969
11_L61_M0.150170.962
60_E116_W0.149770.959
32_R105_A0.149040.954
110_L125_L0.146470.938
29_G32_R0.145340.931
32_R46_F0.144290.924
118_D123_F0.141360.905
51_R87_R0.140860.902
27_L43_P0.140730.901
23_A48_H0.140630.901
6_K26_N0.140550.900
24_R31_R0.140110.897
115_R126_Y0.139960.896
51_R88_I0.138960.890
89_H94_Y0.138420.886
94_Y101_F0.138110.884
70_T79_T0.137840.883
51_R62_Y0.136770.876
22_T52_Y0.13580.870
30_L71_V0.135550.868
57_G96_Y0.132360.848
46_F73_I0.132340.848
53_N62_Y0.13220.847
65_A68_D0.132180.846
12_E51_R0.131440.842
16_N51_R0.130660.837
102_E106_E0.130550.836
33_A39_A0.128820.825
93_S116_W0.127390.816
117_T121_G0.125910.806
7_D10_K0.124580.798
52_Y91_E0.124530.797
4_L118_D0.123750.793
55_E70_T0.123580.791
4_L98_P0.123510.791
50_A59_H0.123080.788
96_Y104_L0.121910.781
17_D21_V0.121490.778
5_C52_Y0.120560.772
14_A91_E0.12020.770
14_A95_K0.120110.769
49_V87_R0.118770.761
67_R98_P0.118550.759
16_N91_E0.118050.756
17_D25_F0.117850.755
61_M91_E0.11730.751
118_D122_D0.117240.751
58_R104_L0.117210.751
5_C96_Y0.117120.750
17_D28_N0.116940.749
33_A73_I0.116170.744
22_T61_M0.11520.738
46_F80_I0.114970.736
66_K70_T0.11410.731
38_G106_E0.113880.729
36_E73_I0.11370.728
25_F91_E0.11350.727
35_R45_D0.112870.723
92_N96_Y0.11250.720
73_I78_L0.112170.718
26_N91_E0.112160.718
32_R104_L0.111490.714
102_E126_Y0.111210.712
82_F86_E0.110510.708
66_K84_E0.110040.705
30_L46_F0.109940.704
8_P38_G0.109770.703
58_R92_N0.108350.694
102_E115_R0.107670.690
26_N50_A0.10760.689
31_R113_E0.107210.687
72_R77_D0.107130.686
79_T121_G0.106230.680
38_G113_E0.10620.680
101_F124_S0.106180.680
79_T119_P0.106010.679
98_P117_T0.10590.678
99_E111_E0.105890.678
23_A50_A0.10540.675
53_N92_N0.105290.674
66_K79_T0.105160.673
62_Y92_N0.10490.672
8_P51_R0.104760.671
40_D49_V0.104470.669
68_D79_T0.10420.667
62_Y94_Y0.103670.664
41_F46_F0.103050.660
6_K25_F0.102840.659
115_R124_S0.102810.658
118_D121_G0.102810.658
17_D26_N0.10280.658
9_E24_R0.102360.656
50_A90_T0.101780.652
4_L126_Y0.10160.651
21_V91_E0.101420.650
24_R82_F0.10140.649
24_R44_E0.101220.648
31_R81_H0.100320.642
32_R89_H0.100180.642
31_R56_E0.09970.638
99_E102_E0.099510.637
70_T83_K0.0990.634
26_N63_L0.098710.632
16_N64_V0.09870.632
32_R96_Y0.098640.632
102_E111_E0.098490.631
53_N89_H0.098180.629
4_L110_L0.098040.628
68_D114_K0.097670.625
22_T86_E0.097640.625
44_E47_E0.097570.625
88_I107_Q0.097410.624
102_E119_P0.097190.622
74_G77_D0.096980.621
6_K48_H0.096920.621
26_N92_N0.096690.619
64_V126_Y0.095540.612
18_P74_G0.095520.612
83_K113_E0.095450.611
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4e2xA0.992189.10.89
3ocjA0.850473.70.907
3dh0A0.87465.90.912
3dlcA0.858364.50.913
3gwzA0.944958.50.916
3i53A0.929156.20.917
3dtnA0.929155.80.917
3lstA0.921353.80.918
3sm3A0.952850.30.92
3dp7A0.921344.90.922
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

Page generated in 0.0461 seconds.