GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2269 - Predicted integral membrane protein (DUF2269)
Pfam: PF10027 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0430
Length: 150
Sequences: 1247
Seq/Len: 8.31
HH_delta: 0.901 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
3_L65_W0.44192.688
144_V148_F0.441252.684
60_P90_G0.386892.353
28_A44_V0.370632.254
8_I147_V0.355962.165
30_R119_P0.353162.148
58_L62_T0.343432.089
80_L84_V0.340432.071
85_L145_L0.33972.066
12_I139_L0.316331.924
48_D97_L0.315941.922
10_A62_T0.307651.871
11_A59_L0.306041.861
82_S146_M0.297221.808
77_P80_L0.287461.748
95_F103_M0.281471.712
102_R106_L0.277371.687
123_R126_R0.276391.681
85_L142_I0.267541.627
13_L55_G0.264571.609
85_L141_V0.264261.607
17_P52_T0.262471.596
138_L142_I0.260841.586
10_A58_L0.256531.560
6_L62_T0.256311.559
90_G94_L0.243371.480
72_W149_K0.233321.419
79_L83_L0.232331.413
91_V94_L0.228731.391
81_V145_L0.224451.365
38_A41_L0.222131.351
120_E124_L0.218681.330
5_F144_V0.212891.295
67_A79_L0.209641.275
9_L140_V0.207521.262
64_L68_W0.206281.255
72_W76_Q0.195851.191
5_F143_V0.193811.179
31_T36_A0.188651.147
51_F54_P0.188571.147
4_K147_V0.18691.137
78_W146_M0.184961.125
56_G90_G0.182711.111
78_W149_K0.181191.102
86_F146_M0.177741.081
40_A43_A0.17631.072
34_P38_A0.175761.069
11_A146_M0.174631.062
94_L102_R0.174211.060
51_F55_G0.17391.058
14_L82_S0.173031.052
53_A56_G0.172511.049
3_L148_F0.17211.047
5_F148_F0.168441.024
3_L69_L0.168281.023
31_T39_R0.166191.011
41_L104_R0.165991.010
53_A57_I0.163710.996
15_V43_A0.163530.995
65_W69_L0.163380.994
77_P84_V0.162960.991
141_V145_L0.16290.991
122_K126_R0.161090.980
45_V50_I0.160790.978
40_A44_V0.16030.975
26_W133_W0.159070.967
53_A104_R0.156740.953
2_L148_F0.155770.947
27_R51_F0.155550.946
27_R46_L0.155170.944
4_K8_I0.154520.940
93_W134_I0.153860.936
26_W29_R0.152660.928
2_L6_L0.152410.927
137_L141_V0.152260.926
32_G37_I0.151260.920
69_L74_L0.150990.918
20_V23_V0.149930.912
79_L85_L0.149810.911
103_M121_Y0.149290.908
14_L59_L0.148020.900
43_A46_L0.147490.897
34_P37_I0.146860.893
81_V84_V0.14550.885
28_A41_L0.144580.879
37_I41_L0.143720.874
18_G52_T0.143070.870
21_A135_A0.142860.869
70_L76_Q0.142580.867
103_M106_L0.142550.867
71_G74_L0.141190.859
14_L21_A0.140540.855
6_L58_L0.140450.854
2_L144_V0.14040.854
122_K125_F0.139990.851
84_V91_V0.138650.843
71_G75_G0.138480.842
54_P58_L0.13760.837
106_L122_K0.137260.835
85_L138_L0.136790.832
20_V47_A0.136180.828
57_I61_V0.135840.826
103_M125_F0.135720.825
82_S86_F0.135210.822
38_A62_T0.134450.818
140_V148_F0.131730.801
72_W79_L0.131260.798
23_V135_A0.130960.797
4_K149_K0.129860.790
140_V149_K0.129520.788
19_F136_F0.128930.784
83_L87_V0.128310.780
10_A104_R0.127840.778
8_I146_M0.127750.777
47_A51_F0.126730.771
65_W68_W0.126480.769
12_I143_V0.126220.768
52_T90_G0.125620.764
35_E38_A0.125170.761
70_L75_G0.124880.760
87_V91_V0.124790.759
20_V136_F0.124760.759
19_F133_W0.124460.757
9_L143_V0.124310.756
5_F9_L0.123810.753
20_V43_A0.123520.751
41_L106_L0.122340.744
22_A52_T0.121790.741
12_I15_V0.121550.739
68_W72_W0.121440.739
86_F142_I0.120890.735
25_M133_W0.120570.733
14_L86_F0.120110.731
24_M47_A0.120010.730
79_L149_K0.119640.728
68_W76_Q0.119230.725
79_L146_M0.118290.719
93_W96_V0.117640.715
7_H63_G0.117550.715
67_A74_L0.117090.712
33_D123_R0.116720.710
23_V133_W0.116630.709
3_L62_T0.116470.708
65_W87_V0.116430.708
84_V88_L0.116420.708
10_A56_G0.116340.708
54_P57_I0.116290.707
24_M28_A0.116280.707
16_G22_A0.115890.705
23_V44_V0.115840.705
35_E39_R0.115250.701
91_V106_L0.115230.701
31_T34_P0.114590.697
17_P82_S0.114580.697
95_F102_R0.114580.697
22_A40_A0.114530.697
33_D36_A0.11420.695
121_Y126_R0.113650.691
49_W56_G0.113490.690
21_A24_M0.113470.690
19_F119_P0.113270.689
92_L136_F0.113210.689
32_G137_L0.112950.687
70_L74_L0.112770.686
31_T37_I0.112620.685
96_V125_F0.112450.684
82_S133_W0.11240.684
106_L141_V0.112380.684
12_I142_I0.112060.682
20_V24_M0.111970.681
14_L56_G0.111830.680
93_W135_A0.111450.678
45_V49_W0.111320.677
67_A70_L0.111170.676
32_G35_E0.111020.675
62_T140_V0.110770.674
5_F141_V0.11060.673
32_G36_A0.109380.665
48_D52_T0.108960.663
91_V102_R0.108830.662
40_A55_G0.108730.661
27_R143_V0.108120.658
12_I61_V0.107730.655
29_R121_Y0.107470.654
53_A94_L0.107350.653
24_M138_L0.107150.652
59_L146_M0.106930.650
19_F46_L0.106830.650
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4ainA0.7219.50.901
4gd3A0.813314.40.907
1kqfC0.893390.915
2xq2A0.947.80.917
4j05A0.77334.90.923
2rddB0.15334.30.925
2akhX0.483.80.927
4a2nB0.923.30.929
3dinE0.47332.40.934
3dh4A0.782.30.935
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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