GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2273 - Small integral membrane protein (DUF2273)
Pfam: PF10031 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 51
Sequences: 293
Seq/Len: 5.75
HH_delta: 0.811 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
34_F38_F0.372252.104
18_L50_D0.347081.962
10_K50_D0.302971.713
21_A43_Y0.298091.685
23_L32_T0.280931.588
18_L22_L0.257961.458
21_A35_I0.256151.448
45_I49_L0.249731.412
15_L45_I0.243071.374
10_K43_Y0.235351.330
27_F38_F0.229371.297
20_L24_I0.213931.209
25_L34_F0.209761.186
24_I32_T0.198821.124
25_L45_I0.198531.122
35_I49_L0.194831.101
20_L37_L0.193181.092
21_A34_F0.192841.090
23_L27_F0.190771.078
30_W34_F0.18771.061
27_F32_T0.181871.028
21_A40_A0.181651.027
22_L26_T0.179381.014
16_I33_L0.179381.014
16_I44_Y0.17420.985
27_F39_A0.173370.980
14_G33_L0.164360.929
13_G22_L0.158790.898
12_I50_D0.157820.892
22_L40_A0.157280.889
14_G43_Y0.155950.882
26_T33_L0.155240.878
31_K35_I0.155140.877
43_Y47_K0.153820.870
24_I29_F0.151690.857
19_I48_Y0.151480.856
29_F41_I0.151420.856
18_L39_A0.150960.853
16_I50_D0.148110.837
9_G42_G0.146520.828
23_L39_A0.145540.823
23_L26_T0.144510.817
15_L48_Y0.141980.803
36_L45_I0.139170.787
13_G33_L0.138460.783
19_I26_T0.137820.779
26_T49_L0.137690.778
10_K21_A0.137480.777
39_A47_K0.136510.772
11_I40_A0.135710.767
19_I22_L0.135440.766
10_K48_Y0.133860.757
16_I41_I0.132760.750
26_T41_I0.13190.746
12_I15_L0.130940.740
14_G37_L0.130140.736
16_I29_F0.127290.720
23_L31_K0.126840.717
11_I37_L0.125370.709
14_G27_F0.124050.701
13_G48_Y0.123730.699
10_K17_G0.123490.698
24_I36_L0.122290.691
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3hd7A0.588217.40.811
3ldtA0.509815.70.815
2kogA0.588214.30.818
3tx3A0.941211.30.826
3fewX180.836
1rh1A0.92167.90.837
3ar4A0.96087.90.837
3b8cA16.60.842
1ciiA0.96086.10.845
3oqgA0.33335.20.85
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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