GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2282 - Predicted integral membrane protein (DUF2282)
Pfam: PF10048 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 53
Sequences: 251
Seq/Len: 4.74
HH_delta: 0.914 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
13_N27_S0.34132.141
26_Q32_D0.299781.880
12_Q37_K0.275311.727
16_A19_A0.267271.676
32_D35_A0.231731.454
26_Q35_A0.226671.422
10_A30_D0.223851.404
21_H26_Q0.219961.380
9_K30_D0.21721.362
8_A37_K0.214821.347
41_K45_E0.213421.339
20_G34_N0.195721.228
9_K28_K0.193851.216
3_K36_W0.190651.196
21_H32_D0.188841.185
24_A41_K0.187731.178
18_T49_G0.185631.164
7_I47_I0.183321.150
47_I50_G0.182841.147
5_Y16_A0.182521.145
46_K49_G0.181111.136
24_A28_K0.178971.123
16_A38_L0.178691.121
14_D37_K0.178281.118
8_A12_Q0.171591.076
14_D36_W0.168771.059
11_G30_D0.168591.058
9_K33_G0.167961.054
38_L46_K0.166321.043
40_P49_G0.163811.028
24_A40_P0.163271.024
12_Q41_K0.161921.016
36_W39_V0.161191.011
1_K47_I0.16091.009
7_I38_L0.157190.986
22_S26_Q0.155950.978
22_S48_V0.149640.939
37_K46_K0.147810.927
3_K16_A0.144980.909
28_K37_K0.144530.907
21_H35_A0.143040.897
1_K40_P0.138920.871
18_T50_G0.135280.849
22_S32_D0.134690.845
18_T21_H0.134290.842
26_Q34_N0.134160.842
39_V43_T0.132340.830
2_E30_D0.132150.829
10_A37_K0.13010.816
43_T46_K0.129920.815
5_Y14_D0.1280.803
12_Q45_E0.123730.776
1_K12_Q0.122640.769
3_K42_G0.122330.767
42_G46_K0.122060.766
16_A22_S0.120890.758
5_Y36_W0.120690.757
45_E48_V0.119480.749
41_K49_G0.119310.748
9_K49_G0.118760.745
8_A33_G0.117250.735
40_P48_V0.117110.735
39_V42_G0.117070.734
19_A29_C0.116580.731
47_I52_L0.115060.722
1_K41_K0.114530.718
33_G51_S0.114180.716
16_A36_W0.114050.715
14_D23_C0.114040.715
1_K5_Y0.111750.701
26_Q33_G0.111090.697
8_A30_D0.110970.696
5_Y41_K0.110340.692
29_C33_G0.10820.679
45_E52_L0.107780.676
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2pm7A0.52832.70.914
1chlA0.22642.50.915
3gaeA0.35851.20.928
1y4jA0.33961.10.929
2xrcA0.88681.10.93
1wktA0.84911.10.93
3bq9A0.339610.931
2kkxA0.339610.932
3vsfA0.90570.90.932
3fjuB0.60380.90.934
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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