GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2283 - Protein of unknown function (DUF2283)
Pfam: PF10049 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 50
Sequences: 336
Seq/Len: 6.72
HH_delta: 0.642 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
24_S32_I0.473112.900
5_Y49_A0.322841.979
5_Y14_I0.264021.619
36_D40_R0.261471.603
27_L33_L0.258741.586
25_E49_A0.257431.578
41_I46_I0.249031.527
13_Y43_G0.24481.501
19_E36_D0.228941.403
11_A47_L0.228661.402
14_I44_I0.210731.292
6_D9_A0.199091.220
16_L44_I0.19621.203
34_D45_E0.194561.193
24_S29_D0.194371.192
17_S40_R0.189241.160
10_D49_A0.185751.139
13_Y44_I0.185551.137
11_A25_E0.185181.135
22_E41_I0.184561.131
11_A45_E0.181771.114
35_Y40_R0.177441.088
10_D50_S0.176651.083
24_S34_D0.171251.050
21_V35_Y0.171011.048
8_E14_I0.170671.046
40_R46_I0.168771.035
6_D47_L0.168261.031
13_Y34_D0.16311.000
2_K15_R0.162720.998
5_Y10_D0.161570.990
10_D46_I0.161410.990
17_S29_D0.159180.976
2_K26_E0.15450.947
2_K16_L0.154020.944
21_V24_S0.150660.924
24_S35_Y0.149970.919
11_A34_D0.148870.913
16_L42_V0.146480.898
25_E32_I0.14540.891
21_V42_V0.144490.886
20_P37_E0.143610.880
4_E42_V0.141490.867
22_E37_E0.139890.858
26_E29_D0.136950.840
6_D30_G0.13180.808
23_E34_D0.130590.801
33_L40_R0.130440.800
33_L41_I0.129230.792
9_A23_E0.127890.784
32_I47_L0.122690.752
16_L45_E0.122410.750
15_R47_L0.121490.745
20_P28_D0.120420.738
3_I22_E0.118640.727
15_R37_E0.118440.726
2_K48_D0.11780.722
25_E39_G0.117560.721
28_D32_I0.116390.714
46_I50_S0.11630.713
4_E7_P0.115850.710
32_I35_Y0.114990.705
7_P20_P0.114550.702
34_D43_G0.114070.699
18_D41_I0.112530.690
25_E35_Y0.112240.688
21_V34_D0.112230.688
26_E30_G0.112130.687
6_D13_Y0.11130.682
14_I30_G0.110620.678
24_S36_D0.109420.671
17_S26_E0.109180.669
3_I29_D0.10840.665
5_Y40_R0.107080.656
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3bu2A0.9895.60.642
4fc3E0.96310.814
3db7A0.8618.30.833
4hpqB0.915.70.837
3elgA0.8614.30.84
1n8fA0.9613.20.842
2ltnA0.411.70.845
3qqzA0.811.20.847
3zyvA0.86110.847
3uncA0.8610.90.847
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

Page generated in 0.0218 seconds.