GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7TM_GPCR_Srab - Serpentine type 7TM GPCR receptor class ab chemoreceptor
Pfam: PF10292 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 324
Sequences: 29280
Seq/Len: 90.37
HH_delta: 0.125 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
57_V147_I1.384333.713
30_A66_C1.341613.598
193_Q196_A0.891412.391
96_C171_C0.879682.359
127_F130_S0.833942.237
71_I74_T0.826232.216
137_W141_L0.798222.141
191_V199_L0.773342.074
94_Y98_I0.768782.062
156_F159_S0.742941.993
165_N168_M0.741691.989
155_Y158_Y0.719281.929
116_S146_Q0.708051.899
73_H76_D0.695721.866
93_T97_F0.694191.862
191_V196_A0.67711.816
57_V113_T0.674541.809
161_E165_N0.673971.808
161_E166_E0.671341.801
122_T127_F0.67071.799
122_T126_F0.662361.777
41_I56_I0.647891.738
160_D163_F0.641261.720
196_A199_L0.637651.710
163_F168_M0.627241.682
64_I106_G0.623781.673
72_L76_D0.619581.662
72_L75_Y0.60651.627
158_Y161_E0.604711.622
38_L56_I0.602291.615
156_F160_D0.60141.613
163_F167_R0.590181.583
199_L202_Y0.582791.563
155_Y159_S0.57741.549
162_D167_R0.558451.498
42_R56_I0.554461.487
162_D168_M0.554451.487
92_S95_R0.554091.486
157_V160_D0.552851.483
47_F52_R0.551431.479
120_E124_A0.54941.474
101_I105_F0.5471.467
159_S162_D0.546871.467
30_A283_I0.536131.438
61_S110_V0.532531.428
160_D166_E0.531851.427
61_S109_L0.530691.423
116_S142_L0.529441.420
74_T78_Y0.525551.410
44_S299_K0.522841.402
155_Y162_D0.521471.399
130_S133_K0.519571.394
190_L193_Q0.515041.381
180_Y183_N0.508981.365
158_Y166_E0.50661.359
199_L203_L0.50231.347
27_S67_T0.500851.343
123_I134_S0.500361.342
192_L196_A0.49981.341
70_I73_H0.497671.335
246_I278_F0.497021.333
180_Y184_I0.496461.332
160_D165_N0.49551.329
200_F204_L0.494851.327
105_F151_L0.486861.306
158_Y162_D0.486781.306
162_D166_E0.486751.306
62_F285_S0.485821.303
196_A200_F0.482231.293
160_D168_M0.481951.293
157_V161_E0.477551.281
159_S166_E0.475311.275
162_D165_N0.473361.270
56_I60_F0.472981.269
94_Y97_F0.472151.266
155_Y160_D0.471891.266
75_Y78_Y0.471111.264
206_K209_K0.469491.259
35_I39_W0.4691.258
130_S134_S0.459961.234
158_Y163_F0.455951.223
89_M92_S0.455881.223
141_L145_F0.455161.221
73_H77_L0.45491.220
53_I143_A0.453331.216
60_F64_I0.452811.215
191_V195_L0.452211.213
179_P183_N0.449321.205
140_I144_F0.444451.192
57_V143_A0.444191.191
236_K240_I0.440961.183
61_S106_G0.440481.181
299_K302_K0.439111.178
200_F203_L0.43611.170
37_A290_Y0.435591.168
36_Y40_K0.433241.162
160_D167_R0.433211.162
109_L150_S0.432031.159
206_K210_L0.428011.148
58_H62_F0.427561.147
163_F166_E0.42671.144
37_A296_I0.422621.134
193_Q197_L0.419771.126
141_L144_F0.419311.125
259_F269_F0.417791.121
29_I283_I0.415021.113
182_V186_F0.413821.110
121_R124_A0.413691.110
31_F63_L0.411031.102
285_S289_L0.409461.098
195_L199_L0.407781.094
71_I76_D0.407691.094
199_L204_L0.405851.089
196_A204_L0.403741.083
144_F148_L0.403531.082
156_F161_E0.40351.082
157_V162_D0.398751.070
161_E168_M0.397831.067
265_K268_Y0.396351.063
74_T77_L0.393791.056
202_Y205_R0.392371.052
155_Y161_E0.392291.052
188_V191_V0.391511.050
298_K301_K0.391011.049
204_L208_K0.390991.049
181_R185_P0.390211.047
203_L206_K0.386711.037
251_F255_F0.386231.036
54_L117_L0.385461.034
181_R184_I0.385021.033
161_E167_R0.384931.032
191_V194_I0.380681.021
71_I75_Y0.380031.019
49_F52_R0.379431.018
111_S115_V0.378991.017
124_A131_Y0.378321.015
127_F134_S0.376821.011
35_I63_L0.375961.008
179_P182_V0.374961.006
125_T129_K0.374691.005
184_I187_I0.372851.000
207_N211_R0.371680.997
205_R209_K0.370970.995
62_F281_Y0.369640.991
235_L239_I0.369220.990
53_I57_V0.369130.990
156_F162_D0.366450.983
32_P35_I0.365580.981
153_I194_I0.364780.978
208_K211_R0.36470.978
162_D178_S0.363790.976
112_F149_I0.363140.974
207_N210_L0.361710.970
189_I193_Q0.361010.968
158_Y165_N0.360630.967
37_A41_I0.359290.964
59_C62_F0.358440.961
241_L288_I0.357330.958
155_Y163_F0.352950.947
235_L238_F0.350940.941
62_F110_V0.350030.939
151_L155_Y0.349120.936
238_F241_L0.347080.931
131_Y135_G0.347040.931
113_T143_A0.346230.929
156_F166_E0.346040.928
268_Y271_L0.345960.928
204_L207_N0.345950.928
124_A128_S0.345810.928
37_A59_C0.342740.919
136_K140_I0.341920.917
247_F251_F0.341140.915
120_E135_G0.340740.914
188_V196_A0.340710.914
191_V198_I0.340280.913
39_W43_N0.337720.906
182_V185_P0.337250.905
142_L146_Q0.335950.901
297_R301_K0.335260.899
167_R270_A0.335090.899
201_R204_L0.333680.895
264_S267_N0.332160.891
282_S286_P0.331850.890
184_I188_V0.33080.887
52_R55_F0.330030.885
40_K296_I0.329340.883
153_I192_L0.328540.881
216_H221_E0.328460.881
157_V167_R0.328070.880
112_F146_Q0.327390.878
92_S96_C0.325050.872
201_R205_R0.32480.871
131_Y134_S0.324660.871
238_F242_S0.324360.870
70_I74_T0.32420.870
197_L201_R0.322730.866
189_I194_I0.322540.865
261_P264_S0.322360.865
33_V59_C0.319990.858
263_M266_P0.318020.853
157_V168_M0.317580.852
270_A274_L0.317560.852
237_P292_K0.316640.849
44_S47_F0.315860.847
187_I190_L0.314960.845
70_I75_Y0.314820.844
33_V287_L0.314170.843
137_W140_I0.313840.842
203_L207_N0.311960.837
109_L113_T0.311650.836
183_N186_F0.309610.830
33_V283_I0.309560.830
26_L283_I0.309470.830
191_V202_Y0.309130.829
44_S302_K0.308130.826
156_F163_F0.307960.826
155_Y165_N0.307860.826
181_R187_I0.307830.826
202_Y206_K0.307790.826
100_R103_Y0.307740.825
37_A286_P0.306180.821
41_I48_H0.306110.821
117_L120_E0.305360.819
159_S167_R0.304850.818
264_S268_Y0.303950.815
155_Y166_E0.303790.815
178_S181_R0.303740.815
159_S168_M0.302960.813
267_N270_A0.302540.811
111_S250_I0.301180.808
185_P189_I0.300440.806
109_L146_Q0.298970.802
220_S223_Y0.298810.801
150_S154_L0.298320.800
198_I202_Y0.297720.799
123_I126_F0.297650.798
146_Q150_S0.297510.798
280_L284_I0.29490.791
151_L154_L0.293380.787
108_F150_S0.291420.782
58_H289_L0.291110.781
153_I156_F0.290850.780
196_A203_L0.290670.780
38_L59_C0.290460.779
245_F281_Y0.288480.774
183_N188_V0.288340.773
186_F190_L0.288240.773
294_K298_K0.287680.772
158_Y179_P0.287030.770
239_I242_S0.286860.769
255_F259_F0.286270.768
183_N187_I0.285880.767
179_P184_I0.285130.765
153_I190_L0.284960.764
188_V193_Q0.284720.764
25_L29_I0.284590.763
54_L120_E0.284150.762
132_E135_G0.283670.761
71_I78_Y0.283530.760
51_T55_F0.281990.756
34_I59_C0.281910.756
166_E178_S0.281520.755
70_I76_D0.281210.754
269_F272_A0.280920.753
48_H52_R0.280760.753
77_L86_P0.280750.753
264_S269_F0.280740.753
193_Q199_L0.280590.753
172_Q175_S0.279690.750
237_P241_L0.279610.750
154_L187_I0.279290.749
120_E131_Y0.279030.748
41_I47_F0.278810.748
157_V165_N0.278810.748
67_T74_T0.277530.744
263_M267_N0.277250.744
72_L95_R0.276540.742
139_G143_A0.276440.741
153_I195_L0.275890.740
179_P187_I0.274690.737
298_K302_K0.274280.736
38_L60_F0.274150.735
211_R215_K0.274030.735
271_L274_L0.273810.734
242_S248_F0.272370.731
52_R296_I0.272350.730
159_S165_N0.271660.729
45_K52_R0.271130.727
242_S246_I0.270460.725
117_L235_L0.270230.725
213_Q216_H0.270130.725
104_N107_L0.269860.724
86_P89_M0.269830.724
37_A40_K0.269330.722
235_L242_S0.267360.717
98_I102_P0.266710.715
293_I299_K0.26650.715
103_Y107_L0.266170.714
30_A34_I0.266020.714
159_S163_F0.265560.712
67_T70_I0.265040.711
112_F150_S0.264540.710
119_I123_I0.263770.707
249_Y252_A0.263520.707
237_P288_I0.263060.706
295_K298_K0.263040.706
199_L207_N0.262950.705
208_K212_K0.262810.705
27_S66_C0.262520.704
65_H282_S0.262420.704
156_F165_N0.261970.703
62_F65_H0.261440.701
253_S256_L0.260780.699
206_K213_Q0.260180.698
66_C117_L0.26010.698
125_T128_S0.259980.697
61_S150_S0.259640.696
109_L147_I0.259170.695
157_V163_F0.258630.694
55_F120_E0.258010.692
51_T117_L0.257470.691
39_W303_R0.257380.690
290_Y293_I0.256790.689
113_T146_Q0.25660.688
180_Y185_P0.256250.687
191_V200_F0.256220.687
45_K48_H0.255720.686
249_Y253_S0.255260.685
190_L194_I0.254940.684
288_I292_K0.254920.684
99_L103_Y0.254820.683
33_V58_H0.254150.682
170_Y173_A0.253910.681
120_E239_I0.25270.678
138_L142_L0.252330.677
154_L161_E0.251950.676
183_N190_L0.25190.676
188_V199_L0.251810.675
254_I258_L0.251620.675
184_I194_I0.250830.673
187_I191_V0.250480.672
158_Y167_R0.250470.672
78_Y86_P0.250390.672
28_I32_P0.25030.671
66_C282_S0.250260.671
205_R210_L0.249460.669
129_K133_K0.249170.668
140_I143_A0.249070.668
210_L214_Q0.248980.668
156_F167_R0.248440.666
34_I37_A0.248190.666
31_F66_C0.247240.663
219_L222_R0.246760.662
87_C90_I0.24660.661
153_I178_S0.245460.658
37_A285_S0.245050.657
114_T121_R0.244550.656
266_P269_F0.244060.655
91_P95_R0.243950.654
156_F178_S0.243910.654
70_I78_Y0.243510.653
53_I140_I0.243410.653
39_W42_R0.24340.653
158_Y178_S0.243380.653
29_I32_P0.242930.652
102_P106_G0.242750.651
195_L202_Y0.242380.650
182_V189_I0.2420.649
62_F121_R0.241820.649
166_E179_P0.241720.648
184_I189_I0.241710.648
161_E179_P0.241590.648
38_L41_I0.2410.646
59_C285_S0.240890.646
34_I286_P0.240880.646
218_T221_E0.240730.646
217_S220_S0.240720.646
198_I203_L0.24060.645
102_P105_F0.240410.645
138_L143_A0.24030.645
153_I193_Q0.240290.645
205_R208_K0.240290.645
31_F35_I0.240090.644
38_L63_L0.239250.642
135_G138_L0.239190.642
189_I196_A0.239150.641
113_T147_I0.239020.641
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA0.97841000.125
3vw7A0.97221000.136
3pblA0.94141000.137
2rh1A0.95681000.14
3uonA0.94141000.141
4dklA0.94141000.154
4eiyA0.9661000.157
3oduA0.93211000.158
4ib4A0.97841000.158
3rzeA0.91671000.159

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