GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Methyltransf_16 - Putative methyltransferase
Pfam: PF10294 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0063
Length: 173
Sequences: 10651
Seq/Len: 61.57
HH_delta: 0.346 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
60_G74_L1.711633.482
146_L150_G1.508973.070
71_R100_S1.497843.047
73_V120_F1.449982.950
121_D147_K1.337312.721
48_R71_R1.3192.683
54_A74_L1.298792.642
50_L120_F1.148972.338
73_V102_R1.034712.105
79_E103_P0.982361.999
44_F47_K0.964131.962
125_A128_V0.941021.914
76_D81_L0.938051.908
79_E82_E0.920491.873
48_R73_V0.8711.772
85_R89_E0.84521.720
142_L152_V0.835181.699
75_T104_L0.819581.667
141_T144_R0.806551.641
81_L103_P0.774561.576
123_I146_L0.770581.568
47_K121_D0.767311.561
48_R120_F0.733721.493
84_L101_V0.69241.409
49_V63_A0.679641.383
146_L152_V0.676061.375
43_L47_K0.674461.372
54_A84_L0.67091.365
61_I87_N0.663341.350
123_I142_L0.645471.313
81_L85_R0.644961.312
81_L101_V0.639811.302
134_L137_P0.636951.296
141_T145_L0.635571.293
88_I99_V0.633651.289
51_E74_L0.630531.283
77_Y105_D0.625181.272
105_D108_D0.61831.258
49_V122_V0.614261.250
73_V100_S0.605981.233
48_R70_A0.593021.206
82_E86_R0.58261.185
82_E85_R0.578661.177
47_K122_V0.565261.150
136_E140_R0.559551.138
86_R89_E0.556081.131
74_L84_L0.539091.097
28_A62_A0.53681.092
64_A98_R0.536781.092
48_R147_K0.526771.072
127_D130_Y0.526351.071
50_L123_I0.524141.066
107_G137_P0.522681.063
52_L142_L0.515151.048
57_G84_L0.510271.038
137_P140_R0.500651.019
83_L86_R0.498931.015
60_G72_V0.494881.007
64_A99_V0.493951.005
104_L108_D0.48930.995
140_R144_R0.488550.994
65_K91_N0.488490.994
86_R90_L0.486980.991
125_A152_V0.48490.987
64_A72_V0.481220.979
61_I91_N0.474020.964
104_L109_E0.471910.960
63_A124_L0.467940.952
56_T80_V0.463270.943
61_I88_I0.457850.931
88_I101_V0.456950.930
75_T102_R0.456280.928
126_S129_L0.449170.914
135_F157_K0.445910.907
132_E135_F0.439970.895
51_E55_G0.439810.895
53_G128_V0.436990.889
54_A101_V0.434980.885
74_L99_V0.432330.880
122_V153_L0.431190.877
76_D101_V0.429310.873
119_S147_K0.428710.872
48_R121_D0.423930.862
49_V69_A0.42390.862
52_L106_W0.421670.858
49_V124_L0.419180.853
43_L46_G0.416610.848
85_R101_V0.416240.847
117_P144_R0.41610.847
51_E75_T0.415860.846
51_E72_V0.415650.846
126_S130_Y0.406470.827
107_G141_T0.405090.824
24_A28_A0.404130.822
60_G99_V0.403640.821
62_A66_L0.403130.820
48_R119_S0.401230.816
48_R118_H0.391740.797
120_F123_I0.388480.790
46_G70_A0.385940.785
23_A27_L0.381550.776
128_V131_D0.375570.764
92_G97_G0.372240.757
31_L66_L0.370450.754
54_A76_D0.367650.748
139_V143_K0.363210.739
133_E136_E0.359840.732
54_A57_G0.358980.730
122_V151_K0.357090.726
51_E57_G0.356860.726
51_E59_P0.356780.726
135_F139_V0.356660.726
47_K151_K0.355830.724
130_Y157_K0.349030.710
78_N103_P0.347230.706
147_K150_G0.345060.702
100_S103_P0.341290.694
32_L66_L0.338330.688
51_E60_G0.338310.688
125_A154_L0.33720.686
44_F69_A0.336210.684
50_L75_T0.33380.679
61_I65_K0.332420.676
137_P141_T0.330220.672
57_G60_G0.329610.671
97_G100_S0.328350.668
74_L101_V0.328220.668
123_I150_G0.323530.658
125_A138_L0.32320.658
28_A32_L0.322740.657
59_P63_A0.319630.650
144_R147_K0.317480.646
65_K92_G0.315280.641
119_S145_L0.31430.639
130_Y156_Y0.312520.636
54_A60_G0.31250.636
63_A72_V0.312370.636
116_E119_S0.312220.635
139_V154_L0.311470.634
102_R109_E0.30840.627
56_T59_P0.307980.627
25_L29_R0.307790.626
125_A130_Y0.307750.626
56_T131_D0.307340.625
74_L88_I0.306990.625
110_L115_L0.305790.622
75_T106_W0.304670.620
28_A59_P0.298810.608
125_A131_D0.296310.603
144_R148_P0.296120.602
106_W109_E0.295210.601
51_E54_A0.293680.597
116_E144_R0.293060.596
49_V72_V0.291620.593
135_F138_L0.291140.592
143_K146_L0.291060.592
76_D80_V0.2910.592
129_L132_E0.290980.592
138_L142_L0.290890.592
53_G106_W0.28850.587
118_H147_K0.288280.587
88_I92_G0.287320.585
153_L157_K0.286990.584
59_P124_L0.286460.583
128_V155_A0.285280.580
110_L141_T0.284630.579
50_L145_L0.28450.579
80_V83_L0.284410.579
26_V29_R0.283120.576
43_L151_K0.282930.576
47_K147_K0.281980.574
61_I90_L0.281820.573
29_R33_S0.281320.572
62_A65_K0.280770.571
58_L126_S0.279930.570
142_L146_L0.27770.565
80_V84_L0.277290.564
57_G74_L0.277260.564
121_D124_L0.275810.561
119_S148_P0.275190.560
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3bzbA0.94899.60.346
4gekA0.94899.60.351
3dmgA0.89699.60.355
3q7eA0.924999.60.364
3vseA0.965399.60.366
4dcmA0.890299.60.367
1vl5A0.901799.60.367
4fsdA199.60.368
3kkzA0.919199.60.369
4hg2A0.843999.60.371

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