GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7TM_GPCR_Srbc - Serpentine type 7TM GPCR chemoreceptor Srbc
Pfam: PF10316 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 273
Sequences: 27555
Seq/Len: 100.93
HH_delta: 0.055 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
19_T55_G1.411213.671
46_F133_L1.40293.650
157_C162_C1.271693.308
81_I84_I1.051712.736
162_C167_C0.964282.509
195_F199_K0.962622.504
80_L84_I0.890212.316
184_I192_I0.879312.288
112_F115_F0.872392.270
123_I127_I0.858822.234
184_I187_S0.8572.230
187_S191_C0.851362.215
187_S190_L0.743661.935
70_L74_F0.738841.922
184_I191_C0.721351.877
184_I188_I0.683881.779
30_I45_Y0.679391.767
46_F98_L0.677851.763
101_I132_A0.670191.744
61_Y65_Y0.669941.743
167_C171_Y0.65721.710
107_V112_F0.639611.664
188_I192_I0.63731.658
187_S195_F0.632851.646
147_C162_C0.632761.646
70_L73_E0.626311.629
36_K41_L0.624631.625
101_I128_I0.620121.613
190_L194_L0.619441.611
194_L197_W0.610731.589
141_Y145_G0.599081.559
81_I86_W0.598321.557
50_I94_I0.596591.552
107_V111_Y0.59651.552
16_S56_F0.584791.521
233_L237_F0.578441.505
183_I187_S0.56731.476
185_I192_I0.565031.470
192_I196_I0.556871.449
191_C198_N0.554991.444
190_L195_F0.549661.430
127_I131_I0.549451.429
105_D109_A0.547681.425
191_C194_L0.530041.379
195_F200_C0.529191.377
49_A53_F0.527871.373
209_L213_N0.524441.364
72_P75_L0.523041.361
60_I63_I0.520941.355
46_F129_I0.520231.353
191_C195_F0.514121.337
47_R51_D0.513571.336
19_T259_V0.512461.333
189_L192_I0.510171.327
27_L45_Y0.508291.322
45_Y49_A0.507961.321
25_Y29_S0.507571.320
165_N168_F0.506711.318
261_E265_V0.503951.311
31_F45_Y0.503821.311
108_F119_Y0.501091.304
105_D120_R0.501021.303
50_I95_R0.498841.298
185_I189_L0.493621.284
196_I199_K0.488981.272
94_I136_G0.487271.268
38_K41_L0.483111.257
173_L178_I0.471711.227
194_L198_N0.470921.225
121_K124_P0.470431.224
71_F75_L0.469881.222
96_S100_L0.466681.214
42_S129_I0.463971.207
115_F119_Y0.458931.194
24_F28_Y0.457831.191
126_F130_I0.456871.189
142_V145_G0.453761.180
80_L83_Y0.45231.177
197_W201_K0.450571.172
187_S192_I0.449441.169
153_V247_G0.443371.153
166_Q169_R0.442531.151
228_F254_K0.441.145
177_M180_F0.439931.144
195_F198_N0.435961.134
188_I191_C0.435831.134
81_I85_G0.435081.132
176_E180_F0.434231.130
177_M182_L0.433211.127
136_G140_Q0.432681.126
191_C197_W0.432551.125
24_F52_V0.431291.122
115_F118_N0.430661.120
98_L129_I0.430131.119
71_F74_F0.42981.118
162_C166_Q0.429621.118
172_W176_E0.424061.103
168_F171_Y0.419241.091
198_N201_K0.419091.090
51_D261_E0.419081.090
196_I200_C0.41791.087
184_I189_L0.416951.085
177_M181_S0.413841.077
183_I191_C0.412251.072
70_L75_L0.41121.070
191_C196_I0.409641.066
128_I132_A0.408911.064
165_N169_R0.406811.058
242_S246_V0.405971.056
58_V62_L0.404031.051
176_E181_S0.403911.051
175_S179_I0.398751.037
80_L85_G0.398221.036
28_Y32_Y0.397471.034
127_I130_I0.396191.031
59_F255_M0.395681.029
26_L30_I0.395251.028
62_L66_I0.393621.024
97_I132_A0.393561.024
130_I134_S0.390811.017
26_L266_F0.390431.016
237_F246_V0.389861.014
181_S184_I0.389511.013
172_W175_S0.386841.006
241_F246_V0.384981.002
179_I183_I0.384281.000
195_F201_K0.383870.999
30_I37_K0.382750.996
194_L199_K0.382320.995
109_A116_Y0.381350.992
135_Y139_D0.380720.990
250_N253_S0.380340.989
166_Q170_Q0.380110.989
160_F165_N0.379560.987
174_T178_I0.375920.978
229_I233_L0.375740.977
43_L102_I0.374920.975
21_L24_F0.374590.975
181_S185_I0.371260.966
184_I190_L0.370510.964
192_I197_W0.369290.961
94_I98_L0.369060.960
20_C52_V0.36870.959
38_K42_S0.36730.956
187_S199_K0.366680.954
18_I259_V0.36620.953
197_W200_C0.365920.952
216_A220_S0.365590.951
116_Y120_R0.36410.947
168_F172_W0.363310.945
173_L177_M0.363080.945
191_C199_K0.362250.942
110_V114_I0.360830.939
247_G252_V0.360710.938
61_Y64_Y0.360120.937
26_L48_F0.359620.936
185_I191_C0.356440.927
192_I195_F0.356420.927
112_F119_Y0.355010.924
106_R109_A0.354940.923
180_F183_I0.353410.919
159_N173_L0.35280.918
210_S214_R0.35210.916
82_F85_G0.351690.915
59_F62_L0.351160.914
175_S180_F0.351010.913
164_V167_C0.349880.910
93_S136_G0.348120.906
173_L180_F0.34780.905
239_P244_E0.343070.893
240_F243_F0.341970.890
120_R128_I0.341220.888
55_G59_F0.340670.886
160_F164_V0.340620.886
178_I183_I0.340530.886
180_F184_I0.340370.885
80_L86_W0.340320.885
138_F142_V0.339990.884
175_S178_I0.339270.883
173_L176_E0.338540.881
51_D257_G0.338360.880
183_I186_L0.338350.880
187_S196_I0.336890.876
176_E179_I0.336720.876
109_A114_I0.336660.876
20_C55_G0.336160.875
186_L190_L0.336080.874
207_K210_S0.334420.870
162_C165_N0.333820.868
212_A216_A0.333780.868
108_F111_Y0.333620.868
190_L198_N0.331980.864
40_D44_F0.330130.859
241_F245_N0.329730.858
22_I48_F0.329390.857
109_A113_P0.328440.854
196_I201_K0.328160.854
231_S234_V0.327870.853
232_F236_Y0.326870.850
178_I181_S0.325580.847
22_I47_R0.325240.846
179_I182_L0.324220.843
186_L196_I0.323090.841
123_I126_F0.321720.837
179_I184_I0.320970.835
37_K41_L0.320940.835
22_I259_V0.320890.835
98_L133_L0.320780.835
167_C170_Q0.320250.833
72_P174_T0.320220.833
190_L199_K0.319830.832
42_S46_F0.31920.830
187_S198_N0.315440.821
256_L260_I0.315170.820
122_K126_F0.314820.819
105_D116_Y0.314360.818
16_S63_I0.313490.816
54_Y258_F0.313410.815
102_I105_D0.313050.814
223_I264_I0.312660.813
95_R227_D0.312310.812
242_S245_N0.311660.811
93_S139_D0.311020.809
15_F259_V0.309850.806
97_I135_Y0.309050.804
159_N172_W0.308480.803
227_D230_P0.308160.802
172_W177_M0.307460.800
134_S137_L0.306330.797
52_V56_F0.305610.795
43_L125_N0.305280.794
178_I182_L0.303750.790
57_S61_Y0.300910.783
48_F51_D0.299820.780
41_L44_F0.298050.775
82_F86_W0.297180.773
203_K208_D0.296910.772
27_L48_F0.296790.772
243_F246_V0.29670.772
114_I120_R0.295980.770
230_P250_N0.293450.763
14_I18_I0.29290.762
161_G164_V0.292750.762
263_F266_F0.292750.762
72_P159_N0.292190.760
27_L52_V0.291890.759
139_D142_V0.291010.757
97_I136_G0.290560.756
28_Y31_F0.290130.755
175_S181_S0.288560.751
174_T177_M0.288490.751
74_F159_N0.288380.750
139_D143_L0.286160.744
225_L229_I0.284830.741
168_F173_L0.284010.739
188_I195_F0.2820.734
132_A136_G0.281940.733
178_I184_I0.281940.733
70_L159_N0.27960.727
246_V250_N0.277190.721
250_N254_K0.277050.721
186_L191_C0.27690.720
26_L29_S0.276680.720
173_L179_I0.276330.719
40_D102_I0.276180.718
169_R173_L0.275610.717
149_F160_F0.275460.717
167_C175_S0.275440.717
42_S126_F0.274820.715
174_T181_S0.274710.715
190_L201_K0.274570.714
16_S60_I0.274170.713
166_Q171_Y0.271030.705
26_L262_A0.270870.705
183_I190_L0.270290.703
48_F261_E0.270190.703
244_E247_G0.269540.701
258_F262_A0.269520.701
126_F129_I0.269430.701
232_F235_S0.269220.700
96_S228_F0.269140.700
58_V156_N0.26890.700
17_I21_L0.268860.699
231_S235_S0.268380.698
129_I133_L0.268350.698
33_S36_K0.2680.697
22_I263_F0.267010.695
43_L105_D0.266740.694
46_F126_F0.265670.691
51_D106_R0.265240.690
167_C172_W0.265240.690
164_V171_Y0.264340.688
238_T247_G0.263530.686
251_A254_K0.26330.685
83_Y86_W0.26290.684
98_L132_A0.262490.683
137_L141_Y0.262320.682
166_Q172_W0.262240.682
133_L257_G0.260670.678
51_D139_D0.260210.677
51_D95_R0.259930.676
94_I132_A0.259010.674
261_E264_I0.258890.674
70_L180_F0.258280.672
27_L49_A0.258110.671
159_N177_M0.256930.668
23_N26_L0.256650.668
240_F244_E0.256430.667
27_L31_F0.256270.667
61_Y80_L0.255850.666
187_S194_L0.255830.666
147_C157_C0.255520.665
119_Y124_P0.254940.663
47_R98_L0.254760.663
170_Q174_T0.254750.663
234_V237_F0.254520.662
245_N249_F0.25420.661
40_D43_L0.254080.661
51_D204_N0.252530.657
36_K39_P0.252490.657
120_R124_P0.252380.657
44_F105_D0.252240.656
30_I36_K0.251660.655
217_L221_F0.250830.653
29_S33_S0.250010.650
26_L261_E0.249760.650
174_T179_I0.249650.649
251_A255_M0.249590.649
167_C173_L0.249270.648
72_P80_L0.248740.647
190_L197_W0.248570.647
248_P253_S0.248250.646
241_F244_E0.247990.645
57_S60_I0.247850.645
54_Y92_G0.246890.642
157_C160_F0.246370.641
251_A260_I0.246150.640
37_K40_D0.245920.640
159_N244_E0.245810.639
257_G261_E0.24460.636
102_I106_R0.244020.635
182_L186_L0.2440.635
95_R103_A0.243890.634
239_P243_F0.24250.631
16_S55_G0.241460.628
159_N176_E0.240360.625
213_N219_D0.240290.625
94_I133_L0.240170.625
199_K202_K0.239790.624
162_C171_Y0.239530.623
192_I199_K0.239420.623
210_S218_I0.23940.623
184_I199_K0.238990.622
50_I97_I0.238790.621
26_L44_F0.238760.621
159_N239_P0.238760.621
21_L34_K0.237960.619
167_C174_T0.237370.618
169_R172_W0.237310.617
43_L120_R0.237030.617
55_G102_I0.236870.616
164_V169_R0.236670.616
244_E248_P0.236540.615
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA0.98171000.055
3vw7A0.97441000.101
2rh1A0.97441000.105
3oduA0.96341000.106
3rzeA0.9781000.109
3emlA0.9781000.115
3uonA0.9781000.117
4dklA0.96341000.122
3v2yA0.9561000.123
4ib4A0.97441000.128

Page generated in 0.0221 seconds.