GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7TM_GPCR_Srd - Serpentine type 7TM GPCR chemoreceptor Srd
Pfam: PF10317 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 292
Sequences: 28745
Seq/Len: 98.44
HH_delta: 0.028 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
12_G49_I1.370664.136
40_N129_Y1.285083.878
198_F202_K0.921122.780
119_K123_F0.863692.606
189_I193_P0.783972.366
113_N116_P0.776172.342
40_N99_S0.736092.221
190_F193_P0.709392.141
80_W84_F0.702612.120
200_R203_I0.699092.110
156_F159_E0.686062.070
108_Y112_R0.684492.066
79_P83_F0.67582.039
102_L128_I0.673222.032
108_Y113_N0.661791.997
201_R205_K0.660821.994
91_H133_F0.651521.966
189_I192_I0.649381.960
20_L39_L0.646881.952
117_S120_R0.629171.899
137_I141_F0.627091.892
23_I39_L0.621851.877
47_I92_F0.596211.799
123_F127_L0.573981.732
195_V199_L0.567951.714
202_K205_K0.554691.674
87_H91_H0.539421.628
55_T68_V0.533021.609
102_L124_I0.5331.608
24_I39_L0.521431.574
12_G273_L0.518481.565
188_P192_I0.516141.558
106_Y110_I0.511481.544
245_I249_L0.508691.535
26_K29_K0.507411.531
9_F50_I0.505731.526
156_F160_Y0.502821.517
122_I126_I0.494361.492
83_F144_T0.491061.482
44_F95_H0.48761.471
228_G282_F0.483921.460
153_L156_F0.4831.458
254_G258_P0.481781.454
36_I125_C0.480411.450
44_F96_S0.479441.447
78_G81_F0.478991.445
26_K289_A0.474561.432
30_S35_S0.474371.432
255_Y258_P0.467621.411
256_E259_F0.465951.406
73_P76_Y0.461691.393
155_Q261_E0.459371.386
43_I47_I0.455551.375
80_W83_F0.452911.367
239_F242_P0.451761.363
19_L280_L0.448881.355
39_L43_I0.448851.355
275_D279_T0.445031.343
124_I128_I0.444291.341
202_K206_F0.443151.337
17_I21_Y0.442521.335
230_T234_L0.439821.327
183_L187_I0.438331.323
75_R78_G0.437681.321
139_F142_S0.423511.278
240_Y268_A0.422341.275
222_H226_V0.420471.269
160_Y163_E0.420111.268
99_S125_C0.418351.262
188_P191_P0.418351.262
91_H136_L0.417161.259
254_G257_H0.416271.256
196_I200_R0.415581.254
95_H132_S0.410691.239
14_I17_I0.409761.237
19_L286_Y0.407261.229
17_I46_L0.40571.224
87_H140_F0.405151.223
225_L228_G0.402681.215
40_N125_C0.402081.213
21_Y25_F0.401291.211
42_A45_D0.399711.206
205_K209_K0.399331.205
197_F201_R0.399241.205
108_Y202_K0.398831.204
45_D275_D0.391121.180
110_I114_P0.387961.171
18_L22_L0.387151.168
32_R35_S0.385211.162
138_F141_F0.383661.158
53_F56_Q0.382531.154
288_K291_L0.382351.154
204_L208_N0.380621.149
11_L273_L0.380541.148
128_I132_S0.375531.133
44_F92_F0.37251.124
97_G101_I0.372281.123
37_L103_S0.369351.115
19_L23_I0.366481.106
13_I46_L0.366021.105
126_I130_I0.36371.098
181_N184_I0.361691.091
272_P276_P0.359851.086
270_L274_I0.359441.085
140_F144_T0.359061.084
249_L260_L0.3571.077
184_I188_P0.355621.073
187_I191_P0.355241.072
203_I207_L0.352411.063
132_S136_L0.351041.059
103_S106_Y0.349761.055
98_W128_I0.34971.055
53_F269_S0.34911.053
241_I245_I0.347691.049
13_I49_I0.347161.048
87_H133_F0.34561.043
185_M189_I0.345511.043
131_P135_M0.342681.034
45_D96_S0.342641.034
176_P180_I0.341851.032
68_V71_Y0.338421.021
100_I196_I0.337961.020
101_I195_V0.33771.019
174_S178_S0.335981.014
235_L278_I0.335491.012
108_Y199_L0.334741.010
204_L207_L0.333811.007
22_L286_Y0.331441.000
107_R110_I0.330990.999
194_I198_F0.330080.996
105_Y109_Y0.329030.993
123_F126_I0.327330.988
8_F273_L0.326990.987
97_G192_I0.32660.986
19_L42_A0.32490.980
68_V75_R0.324350.979
15_L277_L0.324330.979
257_H260_L0.323990.978
51_S54_L0.323180.975
258_P261_E0.322890.974
280_L283_V0.322370.973
109_Y112_R0.321690.971
23_I31_L0.319990.966
48_S272_P0.319160.963
119_K122_I0.318520.961
56_Q69_I0.31810.960
223_R227_K0.317190.957
243_G246_I0.317180.957
45_D271_P0.313790.947
69_I72_G0.313610.946
15_L273_L0.313510.946
187_I192_I0.312830.944
111_L115_S0.312790.944
98_W131_P0.312370.943
112_R206_F0.31150.940
205_K208_N0.309190.933
36_I40_N0.308470.931
247_Y250_S0.307790.929
15_L42_A0.307310.927
94_I188_P0.307070.927
185_M192_I0.306950.926
7_I11_L0.306320.924
118_R122_I0.30630.924
181_N185_M0.305580.922
20_L42_A0.304890.920
110_I115_S0.303550.916
193_P197_F0.302440.913
95_H99_S0.30190.911
255_Y259_F0.300610.907
200_R207_L0.300150.906
253_T256_E0.299280.903
175_S178_S0.297550.898
109_Y113_N0.296760.896
156_F161_N0.295870.893
226_V232_Q0.295630.892
37_L121_I0.295350.891
51_S92_F0.295270.891
200_R204_L0.295030.890
105_Y199_L0.294040.887
19_L276_P0.293650.886
179_L183_L0.293190.885
185_M188_P0.29310.885
41_T45_D0.292470.883
29_K32_R0.292120.882
156_F163_E0.291770.880
55_T81_F0.291760.880
101_I199_L0.291610.880
231_I282_F0.290750.877
31_L35_S0.29020.876
20_L43_I0.288890.872
99_S129_Y0.287510.868
32_R36_I0.287250.867
256_E260_L0.286680.865
206_F209_K0.286070.863
97_G236_P0.285690.862
49_I53_F0.285160.861
220_S223_R0.283910.857
21_Y24_I0.283840.857
185_M190_F0.28380.856
158_P161_N0.283410.855
12_G16_N0.28210.851
34_Y38_L0.281630.850
89_M93_S0.281370.849
30_S33_T0.280870.848
35_S38_L0.280440.846
242_P264_I0.280390.846
261_E266_M0.279880.845
253_T258_P0.27790.839
284_R288_K0.277880.839
134_S138_F0.276970.836
252_F257_H0.276770.835
232_Q236_P0.275940.833
265_F269_S0.275470.831
37_L106_Y0.275370.831
287_R291_L0.27520.830
133_F137_I0.274650.829
90_L136_L0.274480.828
216_E221_M0.273930.827
253_T257_H0.272490.822
244_V247_Y0.271420.819
96_S239_F0.271230.819
127_L131_P0.270270.816
180_I183_L0.269080.812
95_H129_Y0.267990.809
20_L24_I0.267820.808
98_W132_S0.267290.807
36_I122_I0.266060.803
97_G240_Y0.266030.803
51_S55_T0.265920.802
77_F81_F0.26550.801
243_G247_Y0.265380.801
278_I282_F0.264850.799
72_G75_R0.264760.799
139_F181_N0.264330.798
247_Y251_Q0.262750.793
94_I132_S0.262490.792
52_A89_M0.262420.792
135_M139_F0.262360.792
90_L93_S0.261790.790
138_F144_T0.260930.787
40_N122_I0.260710.787
236_P239_F0.260560.786
175_S179_L0.259560.783
156_F162_L0.259230.782
222_H225_L0.259190.782
228_G231_I0.258460.780
196_I199_L0.258040.779
181_N186_T0.257290.776
20_L46_L0.257040.776
216_E219_K0.257010.776
158_P162_L0.25660.774
120_R123_F0.25620.773
103_S229_L0.256150.773
237_L241_I0.255830.772
283_V289_A0.255730.772
20_L23_I0.255260.770
86_Y89_M0.25490.769
38_L106_Y0.254430.768
286_Y289_A0.254090.767
18_L290_I0.254030.767
117_S121_I0.253930.766
139_F143_P0.253740.766
104_F203_I0.252710.763
84_F88_I0.251950.760
270_L273_L0.251810.760
28_P31_L0.25070.757
87_H137_I0.250330.755
113_N202_K0.250220.755
11_L14_I0.250210.755
52_A56_Q0.248550.750
204_L226_V0.247350.746
275_D283_V0.247270.746
105_Y195_V0.247070.746
244_V248_F0.247020.745
154_N159_E0.246160.743
46_L50_I0.245930.742
47_I88_I0.24510.740
277_L281_Y0.244490.738
282_F285_P0.244270.737
129_Y276_P0.243890.736
15_L41_T0.243670.735
182_I192_I0.243650.735
224_Q228_G0.243570.735
264_I268_A0.243110.734
49_I272_P0.241990.730
6_P10_I0.241720.729
104_F200_R0.241510.729
264_I267_L0.24120.728
100_I107_R0.240230.725
144_T147_E0.240180.725
159_E162_L0.239720.723
94_I135_M0.239630.723
246_I249_L0.239130.722
69_I75_R0.238440.720
252_F255_Y0.237710.717
186_T190_F0.237690.717
68_V73_P0.2370.715
99_S128_I0.236580.714
135_M184_I0.236420.713
209_K217_R0.235930.712
124_I132_S0.235880.712
137_I140_F0.235570.711
141_F144_T0.235480.711
182_I186_T0.235330.710
217_R220_S0.234650.708
31_L34_Y0.234520.708
280_L290_I0.234080.706
122_I125_C0.233890.706
130_I133_F0.232740.702
78_G82_C0.232290.701
118_R121_I0.232040.700
103_S107_R0.23180.700
35_S225_L0.231750.699
224_Q284_R0.231350.698
136_L139_F0.231150.698
201_R204_L0.230920.697
9_F13_I0.230250.695
224_Q229_L0.22970.693
255_Y260_L0.229240.692
259_F262_Y0.229040.691
45_D48_S0.228430.689
146_S149_V0.226990.685
192_I195_V0.226260.683
142_S145_D0.225820.681
16_N42_A0.225590.681
10_I14_I0.225460.680
286_Y290_I0.225460.680
180_I185_M0.225310.680
186_T189_I0.224840.679
70_S75_R0.223620.675
273_L276_P0.223480.674
85_C89_M0.223270.674
147_E150_E0.222980.673
104_F229_L0.222940.673
95_H128_I0.222440.671
228_G283_V0.222320.671
131_P134_S0.22190.670
195_V198_F0.221530.669
199_L203_I0.22140.668
120_R124_I0.220830.666
41_T279_T0.220090.664
191_P194_I0.219950.664
13_I17_I0.219920.664
23_I30_S0.219820.663
150_E153_L0.219630.663
103_S109_Y0.219530.662
229_L233_A0.219310.662
23_I103_S0.21920.661
19_L22_L0.218850.660
242_P251_Q0.218820.660
107_R232_Q0.217570.657
111_L114_P0.217210.655
121_I125_C0.217210.655
98_W188_P0.217090.655
137_I144_T0.216980.655
138_F180_I0.216390.653
89_M269_S0.214870.648
44_F47_I0.214080.646
101_I192_I0.213740.645
231_I278_I0.213570.645
193_P196_I0.213420.644
161_N258_P0.21340.644
260_L264_I0.213270.644
9_F49_I0.212850.642
35_S286_Y0.212110.640
284_R287_R0.212010.640
178_S182_I0.211490.638
82_C156_F0.211290.638
108_Y198_F0.210670.636
139_F144_T0.210550.635
269_S275_D0.210390.635
103_S232_Q0.210220.634
277_L280_L0.209720.633
226_V230_T0.208910.630
180_I184_I0.208750.630
182_I185_M0.208650.630
16_N276_P0.208550.629
249_L255_Y0.208530.629
178_S181_N0.208350.629
242_P245_I0.208150.628
13_I50_I0.207410.626
285_P289_A0.207220.625
161_N256_E0.206840.624
98_W101_I0.206780.624
248_F251_Q0.206740.624
45_D107_R0.206310.623
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA0.93151000.028
3vw7A0.93491000.077
2rh1A0.92121000.092
3oduA0.9111000.104
3emlA0.93491000.105
3uonA0.91441000.108
4dklA0.92121000.117
4ib4A0.91781000.118
3rzeA0.9111000.118
3v2yA0.89381000.119

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