GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7TM_GPCR_Sru - Serpentine type 7TM GPCR chemoreceptor Sru
Pfam: PF10322 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 307
Sequences: 24568
Seq/Len: 80.03
HH_delta: 0.217 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
33_T71_N1.191623.269
62_K154_F1.135833.116
144_K148_I0.871872.392
213_I217_L0.858022.354
134_S137_N0.825112.263
190_S193_N0.805652.210
177_P181_G0.793222.176
123_L153_I0.725181.989
92_S105_I0.686641.884
190_S194_I0.682411.872
189_G192_F0.67991.865
191_W195_R0.669131.836
252_M258_T0.657351.803
112_Y158_F0.634751.741
192_F195_R0.617751.695
162_F166_P0.617151.693
77_F81_V0.608751.670
216_I220_F0.605961.662
193_N197_S0.605871.662
255_P258_T0.601611.650
190_S195_R0.601391.650
44_Y61_F0.600251.647
123_L149_W0.590781.621
291_V295_F0.589471.617
176_P185_I0.585061.605
167_A193_N0.577451.584
167_A190_S0.577051.583
45_I61_F0.566851.555
129_L134_S0.561191.539
178_F181_G0.560111.536
91_T104_K0.559471.535
182_A185_I0.55911.534
192_F196_N0.558691.533
217_L220_F0.555991.525
195_R200_H0.555381.523
184_I187_S0.555221.523
193_N200_H0.548531.505
129_L133_Y0.547261.501
183_I186_T0.541751.486
167_A195_R0.537841.475
62_K120_F0.528891.451
50_K57_N0.524221.438
87_T90_F0.522351.433
108_F112_Y0.516431.417
167_A192_F0.51421.411
180_F185_I0.510821.401
189_G193_N0.510331.400
215_N218_M0.50751.392
61_F65_L0.505821.388
176_P182_A0.498361.367
260_G263_S0.49731.364
194_I198_I0.494791.357
69_F113_F0.494221.356
176_P180_F0.492931.352
148_I152_F0.490681.346
176_P181_G0.485391.331
63_S67_M0.485311.331
90_F93_W0.482741.324
147_R151_P0.482561.324
167_A194_I0.478771.313
168_L190_S0.476171.306
197_S200_H0.47571.305
33_T289_C0.474121.301
66_L116_S0.473221.298
182_A187_S0.470571.291
176_P179_P0.465281.276
196_N199_F0.464531.274
189_G194_I0.461681.266
58_P150_I0.46111.265
38_F42_K0.460371.263
65_L69_F0.460281.263
62_K150_I0.458581.258
188_T195_R0.450721.236
127_L131_I0.450631.236
183_I187_S0.448421.230
116_S157_P0.446791.226
195_R199_F0.445771.223
40_I296_Y0.441541.211
210_S214_L0.440481.208
195_R198_I0.440051.207
194_I197_S0.43891.204
242_E246_T0.438731.204
182_A186_T0.436351.197
64_F67_M0.433881.190
169_G189_G0.429411.178
66_L117_S0.429121.177
149_W153_I0.425561.167
180_F183_I0.421321.156
148_I151_P0.418841.149
167_A199_F0.418671.148
266_F276_I0.417831.146
192_F199_F0.417771.146
120_F150_I0.415321.139
77_F93_W0.413391.134
196_N200_H0.411431.129
186_T189_G0.408671.121
39_K43_F0.40761.118
76_I79_F0.403751.108
168_L193_N0.400691.099
118_M207_W0.399661.096
212_I216_I0.399451.096
189_G195_R0.399441.096
252_M255_P0.397751.091
248_T251_S0.395451.085
92_S104_K0.393661.080
176_P184_I0.392261.076
252_M256_Y0.391761.075
129_L217_L0.391431.074
118_M122_V0.390861.072
41_I61_F0.390361.071
168_L192_F0.388251.065
40_I302_F0.387921.064
108_F158_F0.387681.063
115_Y203_F0.387021.062
217_L221_K0.387011.062
245_L249_M0.385541.058
131_I135_P0.384841.056
176_P187_S0.384541.055
190_S200_H0.381991.048
239_R243_R0.381281.046
168_L195_R0.380541.044
122_V210_S0.378861.039
262_I266_F0.377671.036
261_I265_S0.377371.035
263_S266_F0.375931.031
193_N196_N0.373761.025
178_F182_A0.373561.025
137_N140_K0.373371.024
245_L248_T0.373111.023
151_P155_I0.371271.018
131_I136_R0.370771.017
127_L142_C0.37071.017
42_K46_K0.368031.010
194_I200_H0.367721.009
138_H142_C0.366461.005
163_P166_P0.365931.004
240_K244_S0.36511.002
194_I199_F0.365041.001
43_F302_F0.36461.000
130_I141_I0.364050.999
191_W194_I0.363790.998
90_F94_C0.362630.995
164_M167_A0.359790.987
244_S258_T0.3580.982
181_G277_L0.355240.974
220_F224_K0.350350.961
180_F186_T0.350020.960
167_A170_Y0.348610.956
193_N198_I0.347990.955
238_S242_E0.347740.954
38_F68_Q0.346770.951
58_P62_K0.34640.950
241_A245_L0.345640.948
246_T249_M0.345470.948
241_A249_M0.344780.946
168_L188_T0.344440.945
178_F185_I0.344050.944
203_F207_W0.343750.943
34_I68_Q0.343710.943
117_S256_Y0.342720.940
187_S192_F0.342710.940
286_C290_I0.3420.938
157_P161_T0.341220.936
187_S193_N0.341030.935
167_A188_T0.337710.926
179_P197_S0.336330.923
108_F165_F0.335220.920
168_L198_I0.334940.919
78_D82_F0.334540.918
167_A191_W0.334030.916
273_S276_I0.333840.916
244_S252_M0.333750.916
119_L153_I0.333240.914
188_T191_W0.333240.914
183_I190_S0.332440.912
119_L207_W0.33160.910
119_L156_Y0.331390.909
112_Y161_T0.331080.908
75_F285_D0.33080.907
129_L214_L0.329880.905
219_F223_R0.32960.904
182_A189_G0.3290.902
256_Y259_N0.328380.901
248_T252_M0.327430.898
178_F183_I0.326790.896
74_F110_Y0.326750.896
188_T193_N0.325730.894
185_I189_G0.323130.886
71_N75_F0.321590.882
126_L214_L0.321570.882
272_Y275_Y0.321350.882
277_L282_F0.319130.875
242_E245_L0.318590.874
137_N141_I0.318570.874
144_K147_R0.317110.870
189_G200_H0.315640.866
248_T298_T0.314510.863
167_A198_I0.313570.860
246_T250_I0.313080.859
296_Y299_H0.312950.858
121_P211_I0.311170.854
131_I138_H0.311130.853
156_Y160_F0.310420.852
168_L199_F0.309750.850
133_Y221_K0.30940.849
116_S120_F0.309390.849
44_Y51_K0.30920.848
32_P289_C0.309040.848
56_I60_V0.308840.847
181_G187_S0.308190.845
251_S294_Y0.307760.844
125_C215_N0.305810.839
178_F184_I0.305330.838
178_F186_T0.304690.836
71_N74_F0.304320.835
42_K45_I0.303010.831
253_L257_I0.302810.831
187_S194_I0.302320.829
119_L157_P0.302280.829
134_S141_I0.302120.829
180_F188_T0.301810.828
190_S196_N0.301050.826
298_T301_I0.300580.825
132_L136_R0.299960.823
176_P183_I0.299750.822
81_V87_T0.299340.821
167_A189_G0.299020.820
51_K54_N0.298150.818
245_L250_I0.297740.817
167_A197_S0.297390.816
178_F187_S0.296470.813
211_I253_L0.29640.813
191_W196_N0.296370.813
188_T197_S0.296260.813
89_I93_W0.295490.811
111_Y161_T0.294220.807
66_L113_F0.293580.805
190_S198_I0.293120.804
160_F164_M0.292830.803
122_V207_W0.292250.802
189_G197_S0.292150.801
126_L210_S0.290640.797
158_F162_F0.290360.797
80_L84_I0.290.796
179_P187_S0.289950.795
264_I267_L0.288990.793
159_C162_F0.288640.792
247_L251_S0.288520.791
59_H124_F0.288510.791
91_T169_G0.287780.789
178_F194_I0.287780.789
115_Y160_F0.287590.789
244_S249_M0.286780.787
179_P182_A0.286750.787
116_S153_I0.285890.784
130_I142_C0.285860.784
249_M253_L0.28520.782
40_I44_Y0.285090.782
286_C289_C0.284890.781
68_Q72_L0.284350.780
197_S201_L0.284020.779
45_I62_K0.283340.777
176_P186_T0.283210.777
190_S199_F0.283070.777
188_T194_I0.282880.776
222_L243_R0.281880.773
109_F113_F0.281750.773
191_W197_S0.280640.770
44_Y50_K0.279930.768
80_L88_G0.279820.768
243_R247_L0.279270.766
198_I201_L0.279010.765
180_F184_I0.27840.764
188_T198_I0.27830.763
81_V84_I0.277630.762
180_F194_I0.277140.760
31_I35_F0.276380.758
119_L203_F0.276380.758
182_A190_S0.276230.758
247_L258_T0.275460.756
243_R248_T0.275330.755
35_F38_F0.275080.755
128_R292_P0.274760.754
47_S50_K0.274670.753
54_N57_N0.274430.753
184_I188_T0.273580.750
67_M291_V0.271590.745
204_S207_W0.271470.745
176_P189_G0.271150.744
181_G194_I0.270930.743
192_F200_H0.27070.743
236_K239_R0.26960.740
160_F163_P0.268730.737
180_F189_G0.268430.736
105_I109_F0.268310.736
248_T253_L0.267950.735
181_G184_I0.267590.734
181_G201_L0.266890.732
252_M259_N0.266780.732
255_P259_N0.266410.731
118_M257_I0.265730.729
168_L194_I0.264830.726
40_I64_F0.264620.726
182_A191_W0.264360.725
191_W200_H0.264320.725
276_I280_R0.264080.724
77_F80_L0.263910.724
80_L83_R0.263770.724
147_R150_I0.263130.722
192_F197_S0.262870.721
275_Y279_I0.262220.719
36_I64_F0.262150.719
179_P183_I0.261860.718
180_F187_S0.261190.716
179_P188_T0.261180.716
40_I43_F0.260410.714
185_I188_T0.25970.712
241_A252_M0.259620.712
222_L225_L0.258960.710
110_Y114_N0.258760.710
187_S190_S0.258520.709
191_W198_I0.258310.709
180_F190_S0.258060.708
111_Y114_N0.2580.708
142_C149_W0.257660.707
124_F249_M0.257280.706
55_G59_H0.25720.706
181_G191_W0.256390.703
159_C163_P0.255750.702
73_L113_F0.255670.701
77_F89_I0.255480.701
179_P196_N0.255330.700
32_P35_F0.25530.700
278_L281_P0.254950.699
191_W199_F0.254180.697
242_E249_M0.253190.695
184_I192_F0.25270.693
248_T258_T0.252490.693
179_P184_I0.252440.692
294_Y298_T0.252410.692
124_F127_L0.252290.692
168_L191_W0.251450.690
126_L130_I0.251310.689
283_G287_R0.251110.689
202_F207_W0.251010.689
41_I64_F0.2510.689
183_I194_I0.250990.689
255_P290_I0.250870.688
107_V110_Y0.250820.688
241_A246_T0.250220.686
58_P147_R0.248380.681
140_K143_R0.248240.681
115_Y157_P0.247560.679
62_K147_R0.247160.678
41_I68_Q0.246940.677
192_F198_I0.246930.677
55_G146_F0.246820.677
179_P185_I0.246490.676
197_S269_F0.246280.676
245_L252_M0.246220.675
48_K51_K0.24490.672
177_P201_L0.244790.671
125_C218_M0.244670.671
177_P180_F0.244250.670
246_T252_M0.243870.669
56_I59_H0.24370.669
50_K54_N0.243460.668
128_R131_I0.243220.667
181_G186_T0.243060.667
185_I190_S0.242780.666
130_I133_Y0.242170.664
251_S255_P0.241910.664
167_A196_N0.241640.663
106_L110_Y0.241440.662
260_G267_L0.241440.662
107_V111_Y0.241240.662
177_P182_A0.241120.661
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA0.97071000.217
2rh1A0.94791000.252
4dklA0.94141000.257
3uonA0.95441000.26
3vw7A0.95441000.263
3oduA0.94461000.27
3emlA0.95771000.27
3rzeA0.91861000.272
2ks9A0.94791000.276
1u19A0.94461000.276

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