GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7TM_GPCR_Str - Serpentine type 7TM GPCR chemoreceptor Str
Pfam: PF10326 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 307
Sequences: 29856
Seq/Len: 97.25
HH_delta: 0.054 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
12_S49_S1.353663.836
40_Y139_W1.116483.164
214_Y218_K1.029182.916
124_R128_W0.870952.468
164_N184_E0.863042.446
162_L185_N0.841572.385
113_R116_K0.810772.297
80_S84_I0.776562.201
217_I221_K0.736382.087
40_Y99_L0.710922.015
79_K83_Q0.706162.001
23_I39_I0.67341.908
108_Y112_C0.666271.888
102_I138_I0.650191.842
91_G143_V0.634811.799
245_L248_Q0.634591.798
244_A248_Q0.63371.796
47_I92_C0.617861.751
108_Y113_R0.61141.733
281_S284_I0.609491.727
9_F50_I0.607681.722
211_I215_C0.599761.700
186_G191_N0.588081.666
262_I266_L0.584521.656
24_L39_I0.583061.652
20_I39_I0.582641.651
218_K221_K0.57991.643
122_G125_F0.576811.635
87_A91_G0.567791.609
44_F95_M0.56551.602
57_P60_H0.563861.598
78_S81_I0.540091.530
12_S289_A0.536281.520
43_I47_I0.516971.465
32_G35_K0.512331.452
121_S125_F0.512021.451
117_L121_S0.510071.445
148_S151_E0.508621.441
218_K222_K0.504271.429
281_S285_S0.502111.423
280_I283_L0.499211.415
238_Q242_F0.494591.402
106_Y110_A0.491391.392
216_G219_I0.489391.387
30_S35_K0.483531.370
245_L249_T0.482191.366
158_R162_L0.474281.344
17_S21_Y0.474041.343
19_L296_I0.472151.338
108_Y218_K0.469091.329
213_I217_I0.467171.324
45_E291_D0.465981.320
44_F96_S0.464771.317
27_S30_S0.464261.316
110_A114_P0.461471.308
116_K119_Y0.459391.302
80_S83_Q0.458591.300
277_S282_I0.457131.295
122_G126_I0.456321.293
109_W120_F0.456141.293
142_L146_F0.456091.292
58_I81_I0.454291.287
221_K225_K0.451931.281
39_I43_I0.451841.280
162_L165_Y0.447211.267
128_W137_I0.43531.234
98_S208_S0.431651.223
291_D295_V0.431131.222
102_I134_I0.425271.205
106_Y121_S0.423731.201
157_L162_L0.423271.199
199_L203_I0.423071.199
19_L302_Y0.419681.189
75_F78_S0.419651.189
94_G204_I0.413691.172
97_F208_S0.412141.168
158_R163_E0.412141.168
282_I285_S0.409761.161
147_F151_E0.409491.160
121_S126_I0.408531.158
162_L166_G0.408241.157
278_N283_L0.405571.149
95_M142_L0.405371.149
99_L135_F0.405051.148
112_C222_K0.403941.145
36_Y135_F0.40391.145
18_L22_L0.403021.142
157_L163_E0.402041.139
156_Y163_E0.400121.134
141_L145_F0.399911.133
108_Y215_C0.399471.132
17_S46_I0.398221.128
128_W136_G0.396731.124
136_G140_F0.396141.123
97_F101_A0.395631.121
107_R110_A0.39551.121
288_P292_P0.39461.118
21_Y25_T0.392371.112
14_F17_S0.389251.103
156_Y159_E0.389241.103
161_L166_G0.387541.098
42_S45_E0.385191.092
110_A117_L0.384111.088
163_E166_G0.382881.085
44_F92_C0.382631.084
13_L46_I0.381491.081
272_D276_F0.380331.078
257_Y284_I0.377821.071
163_E185_N0.3761.065
127_I136_G0.374911.062
40_Y135_F0.374241.060
239_K243_K0.374031.060
157_L164_N0.370951.051
163_E184_E0.367871.042
32_G36_Y0.367851.042
192_W196_I0.36661.039
271_I275_F0.364511.033
250_I254_I0.36451.033
244_A249_T0.364441.033
241_L244_A0.363681.031
195_F199_L0.362711.028
277_S283_L0.362331.027
159_E163_E0.362231.026
100_L212_I0.361941.026
157_L165_Y0.360821.022
266_L277_S0.359361.018
158_R164_N0.358371.016
260_V263_V0.357731.014
161_L164_N0.357581.013
111_V115_K0.357561.013
134_I138_I0.357431.013
197_G200_I0.35681.011
105_I211_I0.356691.011
165_Y185_N0.355731.008
220_Y223_I0.354961.006
165_Y184_E0.354171.004
101_A211_I0.353921.003
11_L289_A0.353861.003
246_V249_T0.353711.002
116_K120_F0.353571.002
286_L290_I0.351870.997
159_E165_Y0.348690.988
95_M99_L0.347020.983
101_A215_C0.346970.983
22_L302_Y0.345660.979
41_F45_E0.345170.978
119_Y122_G0.344990.978
31_L35_K0.34490.977
163_E186_G0.343330.973
101_A208_S0.342950.972
159_E162_L0.341270.967
158_R165_Y0.340450.965
105_I215_C0.340090.964
55_V89_Y0.339880.963
120_F125_F0.339350.962
19_L42_S0.338620.960
278_N282_I0.337830.957
113_R120_F0.335560.951
220_Y224_K0.335190.950
244_A298_I0.334890.949
77_L81_I0.333510.945
124_R127_I0.332450.942
145_F149_P0.332280.942
271_I274_G0.331610.940
15_L293_L0.331040.938
15_L289_A0.33050.937
20_I42_S0.330110.935
58_I61_S0.3280.929
212_I216_G0.324830.920
15_L42_S0.324490.920
238_Q241_L0.323970.918
87_A143_V0.323820.918
37_L103_H0.322690.914
123_W126_I0.322280.913
161_L186_G0.321380.911
272_D275_F0.321130.910
27_S305_A0.320360.908
86_L89_Y0.320330.908
240_Q244_A0.32020.907
280_I284_I0.319910.907
258_I262_I0.318550.903
204_I208_S0.318210.902
110_A115_K0.317610.900
103_H106_Y0.317520.900
23_I31_L0.317440.900
244_A247_I0.31660.897
45_E96_S0.316450.897
222_K225_K0.316220.896
210_F214_Y0.316150.896
105_I109_W0.315420.894
161_L165_Y0.314870.892
274_G277_S0.314730.892
104_F216_G0.313170.887
21_Y24_L0.312710.886
221_K224_K0.311870.884
45_E287_Y0.311330.882
158_R184_E0.309970.878
12_S16_N0.309180.876
276_F280_I0.308820.875
109_W112_C0.308570.874
29_K32_G0.307610.872
198_M202_C0.307060.870
145_F200_I0.307050.870
158_R166_G0.306270.868
20_I24_L0.304920.864
90_C93_F0.304420.863
36_Y40_Y0.302980.859
164_N186_G0.302550.857
251_I254_I0.30240.857
256_M259_P0.300880.853
106_Y117_L0.299690.849
98_S138_I0.298510.846
159_E166_G0.298170.845
302_Y305_A0.297580.843
8_G289_A0.297220.842
84_I88_I0.297030.842
97_F257_Y0.29570.838
34_Y37_L0.295320.837
166_G185_N0.29530.837
27_S31_L0.291870.827
20_I43_I0.291450.826
56_Q59_I0.291370.826
200_I204_I0.290520.823
34_Y38_M0.290360.823
273_L276_F0.289590.821
138_I142_L0.289470.820
55_V59_I0.288850.819
277_S281_S0.287910.816
61_S76_F0.286890.813
82_G87_A0.286640.812
89_Y93_F0.286080.811
296_I299_I0.285630.809
249_T253_F0.285170.808
223_I226_L0.284840.807
201_M265_I0.284770.807
109_W113_R0.284570.806
143_V147_F0.284460.806
157_L186_G0.284110.805
191_N195_F0.283980.805
300_K304_K0.283560.804
252_P294_P0.282460.800
219_I223_I0.281310.797
123_W127_I0.279210.791
205_M261_F0.279160.791
157_L166_G0.278860.790
165_Y186_G0.278860.790
205_M209_F0.277960.788
19_L292_P0.277740.787
279_I283_L0.276370.783
156_Y162_L0.276260.783
275_F278_N0.276180.783
291_D299_I0.275190.780
149_P193_P0.274890.779
90_C146_F0.274350.777
203_I207_I0.273360.775
88_I92_C0.27320.774
28_P31_L0.272910.773
248_Q255_F0.272840.773
205_M258_I0.271520.769
140_F143_V0.271510.769
45_E48_F0.271140.768
162_L186_G0.268930.762
94_G145_F0.268180.760
38_M106_Y0.267950.759
91_G146_F0.267740.759
16_N42_S0.266760.756
201_M205_M0.266480.755
19_L23_I0.266360.755
35_K302_Y0.265650.753
166_G184_E0.264520.750
35_K38_M0.26430.749
248_Q252_P0.263630.747
261_F264_F0.263190.746
158_R161_L0.26210.743
48_F288_P0.261990.742
120_F123_W0.261930.742
202_C208_S0.261820.742
49_S56_Q0.261650.741
205_M208_S0.261530.741
205_M260_V0.261370.741
85_L89_Y0.260950.739
19_L22_L0.260810.739
279_I284_I0.260720.739
13_L49_S0.259970.737
20_I23_I0.259820.736
250_I253_F0.259720.736
299_I305_A0.259260.735
196_I199_L0.258050.731
157_L184_E0.257980.731
156_Y185_N0.25770.730
261_F265_I0.255360.724
180_Y275_F0.255190.723
254_I258_I0.255150.723
277_S284_I0.254160.720
263_V266_L0.253460.718
111_V114_P0.253410.718
302_Y306_I0.252980.717
294_P298_I0.251270.712
104_F215_C0.251130.712
212_I220_Y0.250860.711
98_S141_L0.250820.711
243_K246_V0.250750.711
11_L14_F0.250610.710
121_S124_R0.250480.710
15_L41_F0.250260.709
94_G142_L0.248850.705
276_F279_I0.248430.704
196_I200_I0.248210.703
104_F219_I0.247850.702
277_S280_I0.247070.700
293_L297_F0.246820.699
164_N185_N0.246410.698
20_I46_I0.24550.696
49_S288_P0.245080.694
10_V14_F0.244920.694
298_I301_D0.244820.694
224_K227_S0.244390.693
237_L240_Q0.244070.692
55_V285_S0.243050.689
98_S142_L0.242990.689
292_P295_V0.241380.684
113_R218_K0.241260.684
264_F267_P0.241080.683
146_F150_D0.240640.682
156_Y165_Y0.240350.681
185_N191_N0.239770.679
98_S204_I0.23870.676
156_Y184_E0.238620.676
209_F213_I0.238520.676
116_K122_G0.238340.675
278_N284_I0.23750.673
252_P256_M0.2370.672
280_I285_S0.23650.670
216_G223_I0.236280.670
58_I75_F0.235980.669
98_S102_I0.235780.668
117_L122_G0.235070.666
270_G273_L0.23440.664
46_I50_I0.234230.664
143_V149_P0.234090.663
161_L185_N0.233240.661
157_L161_L0.232940.660
44_F98_S0.231760.657
109_W121_S0.231490.656
48_F93_F0.231390.656
96_S256_M0.230650.654
73_G76_F0.229730.651
158_R186_G0.229680.651
9_F60_H0.229590.651
162_L184_E0.2290.649
195_F198_M0.228660.648
31_L34_Y0.228510.648
145_F148_S0.228320.647
220_Y242_F0.227860.646
226_L237_L0.22690.643
8_G286_L0.226790.643
158_R269_F0.226680.642
137_I141_L0.226510.642
112_C219_I0.22620.641
128_W134_I0.226130.641
144_Y148_S0.226090.641
272_D277_S0.225910.640
241_L245_L0.225460.639
247_I251_I0.22520.638
41_F295_V0.225120.638
260_V264_F0.224430.636
44_F47_I0.224380.636
109_W116_K0.223840.634
252_P290_I0.223770.634
294_P299_I0.223520.633
197_G201_M0.223320.633
9_F49_S0.223030.632
93_F97_F0.222640.631
56_Q60_H0.222590.631
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA0.90881000.054
3vw7A0.8991000.102
3emlA0.90231000.102
3oduA0.87621000.106
2rh1A0.8861000.106
3uonA0.88271000.106
4eiyA0.90231000.108
3rzeA0.88271000.122
4ib4A0.88271000.123
3v2yA0.85991000.125

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