GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
7TM_GPCR_Sri - Serpentine type 7TM GPCR chemoreceptor Sri
Pfam: PF10327 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 303
Sequences: 30208
Seq/Len: 99.7
HH_delta: 0.082 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
178_S181_N1.393733.793
53_S141_I1.271043.459
22_S62_T1.208243.289
211_F215_D1.01552.764
121_R124_S0.881842.400
131_W135_F0.822022.237
214_I218_R0.751352.045
81_F85_Y0.715121.946
110_I140_C0.6991.902
99_F145_F0.693931.889
116_H120_A0.660391.797
278_L281_F0.620161.688
60_H100_L0.613341.669
116_H121_R0.61231.667
166_R171_E0.604261.645
208_I212_L0.604231.645
277_C280_I0.603971.644
189_P193_F0.602081.639
53_S107_S0.597941.627
178_S192_I0.589421.604
95_T99_F0.580381.580
215_D218_R0.578831.575
277_C281_F0.574631.564
55_T58_D0.571671.556
165_I171_E0.570431.553
165_I170_P0.564591.537
149_I153_F0.561831.529
68_I72_P0.554271.509
54_C58_D0.553491.506
275_E280_I0.547591.490
33_I52_I0.547161.489
274_S279_A0.545051.483
213_T216_M0.543621.480
22_S286_S0.539241.468
40_L45_Y0.5361.459
110_I136_F0.533111.451
135_F139_F0.532921.450
116_H215_D0.515991.404
166_R169_Y0.512021.394
258_I262_V0.511651.393
167_E274_S0.504851.374
129_P132_F0.504751.374
215_D219_M0.497081.353
167_E170_P0.496041.350
191_F195_F0.494941.347
181_N193_F0.494891.347
56_L60_H0.492211.340
114_R118_A0.491751.338
181_N191_F0.491421.338
45_Y48_L0.488871.331
241_S295_T0.487961.328
57_T103_F0.485691.322
134_I138_F0.484861.320
278_L282_S0.48311.315
42_N45_Y0.481071.309
190_W194_F0.47781.300
81_F84_R0.475361.294
34_I52_I0.474771.292
165_I169_Y0.473861.290
27_S31_Y0.471961.285
102_I201_G0.471391.283
210_I214_I0.469721.278
270_A273_I0.469291.277
190_W193_F0.467631.273
84_R156_M0.466261.269
29_G293_I0.465911.268
288_N292_L0.464671.265
152_Y156_M0.4641.263
52_I56_L0.462831.260
178_S190_W0.462111.258
124_S127_V0.461441.256
68_I82_L0.459451.251
103_F144_P0.456771.243
178_S191_F0.453891.235
181_N189_P0.451741.230
243_I247_A0.451731.229
178_S193_F0.449411.223
30_I52_I0.444571.210
218_R222_K0.444331.209
29_G299_Y0.443891.208
99_F148_F0.443431.207
194_F197_L0.443191.206
37_S302_F0.442621.205
180_P192_I0.43991.197
136_F140_C0.439581.196
28_L32_L0.434051.181
192_I196_I0.432251.176
189_P192_I0.431251.174
58_D288_N0.427441.163
57_T104_Q0.427241.163
274_S280_I0.425121.157
193_F198_A0.422731.151
53_S137_Y0.420861.145
135_F138_F0.419861.143
253_I281_F0.417481.136
181_N190_W0.416891.135
283_S287_V0.416491.134
273_I277_C0.415841.132
161_Q165_I0.413271.125
120_A219_M0.41231.122
24_I27_S0.411441.120
178_S189_P0.407251.108
179_L190_W0.405011.102
44_R47_L0.404871.102
192_I195_F0.402141.095
116_H212_L0.401291.092
238_A241_S0.399921.088
161_Q171_E0.39961.088
179_L195_F0.399331.087
151_F154_S0.398691.085
107_S137_Y0.397811.083
179_L191_F0.397621.082
23_F59_I0.396671.080
77_Y80_G0.394751.074
118_A125_K0.394651.074
153_F156_M0.394441.074
44_R48_L0.393231.070
105_I109_V0.392131.067
285_S289_M0.39061.063
180_P191_F0.390321.062
165_I168_N0.387941.056
95_T152_Y0.386481.052
22_S26_N0.385981.051
105_I205_C0.384921.048
115_K118_A0.38431.046
138_F142_L0.383331.043
192_I267_F0.382521.041
235_H239_V0.382521.041
106_E205_C0.381761.039
27_S59_I0.380821.036
274_S277_C0.380251.035
166_R170_P0.378851.031
67_P70_L0.377411.027
248_T291_V0.376721.025
180_P190_W0.376051.024
109_V208_I0.375411.022
274_S278_L0.373531.017
95_T145_F0.373381.016
108_L209_F0.368481.003
31_Y35_F0.367321.000
275_E279_A0.36630.997
161_Q166_R0.365960.996
21_I286_S0.365780.996
118_A122_I0.36510.994
150_C153_F0.363690.990
181_N192_I0.361650.984
279_A282_S0.360930.982
271_Q275_E0.36050.981
252_C255_P0.360340.981
217_F220_L0.360090.980
217_F221_K0.359840.979
37_S40_L0.359380.978
272_V276_I0.359280.978
218_R221_K0.358390.975
236_K240_R0.356840.971
119_I123_L0.356350.970
46_Y137_Y0.355940.969
179_L193_F0.354050.964
125_K128_L0.353250.961
57_T100_L0.353210.961
62_T66_Q0.352930.961
104_Q252_C0.352790.960
64_L100_L0.352110.958
195_F265_F0.351670.957
32_L299_Y0.349990.953
43_F47_L0.349440.951
117_Q120_A0.348790.949
41_D44_R0.348750.949
271_Q274_S0.348710.949
196_I200_F0.347330.945
254_L258_I0.347160.945
113_L212_L0.346250.942
190_W267_F0.345880.941
194_F198_A0.345050.939
269_D273_I0.341770.930
283_S286_S0.340720.927
151_F156_M0.340210.926
109_V212_L0.340020.925
193_F197_L0.339450.924
111_C114_R0.338290.921
164_Y170_P0.336270.915
191_F198_A0.335380.913
168_N171_E0.334110.909
113_L208_I0.333640.908
179_L192_I0.333640.908
106_E143_F0.331840.903
193_F196_I0.330720.900
143_F147_I0.33060.900
256_P259_F0.330480.899
195_F198_A0.330040.898
106_E140_C0.328920.895
276_I280_I0.328920.895
207_V211_F0.328630.894
109_V205_C0.32680.889
293_I296_T0.326610.889
163_E167_E0.325350.886
65_M97_W0.324820.884
71_F79_V0.322730.878
118_A123_L0.321940.876
140_C144_P0.321820.876
216_M220_L0.320980.874
130_K134_I0.32050.872
144_P148_F0.320290.872
69_P73_I0.318330.866
25_L286_S0.316910.863
191_F267_F0.316890.862
103_F107_S0.316560.862
201_G205_C0.316420.861
202_G256_P0.316150.860
25_L55_T0.314790.857
58_D115_K0.314370.856
94_M97_W0.312440.850
112_F213_T0.312320.850
273_I276_I0.311850.849
202_G257_F0.311470.848
190_W269_D0.310510.845
164_Y167_E0.310490.845
233_Q236_K0.310130.844
219_M222_K0.310120.844
107_S141_I0.310030.844
267_F271_Q0.309880.843
31_Y34_I0.308710.840
273_I280_I0.308520.840
217_F239_V0.307430.837
180_P193_F0.304520.829
198_A268_E0.304380.828
93_L97_W0.30270.824
42_N46_Y0.302660.824
113_L117_Q0.301450.820
29_G55_T0.300560.818
147_I151_F0.299990.816
59_I63_F0.299810.816
191_F194_F0.296990.808
273_I281_F0.295940.805
209_F213_T0.295660.805
239_V245_Q0.295430.804
269_D272_V0.294630.802
245_Q249_S0.294170.801
105_I253_I0.294090.800
76_G79_V0.293130.798
191_F196_I0.292480.796
160_E165_I0.291850.794
179_L189_P0.291850.794
131_W134_I0.291790.794
114_R125_K0.291590.794
29_G32_L0.291030.792
75_A79_V0.290630.791
244_A291_V0.290010.789
45_Y52_I0.289250.787
64_L67_P0.289120.787
25_L290_I0.289010.787
191_F268_E0.288880.786
297_P301_K0.288440.785
137_Y141_I0.28820.784
202_G254_L0.287290.782
153_F157_S0.286290.779
29_G289_M0.286090.779
33_I41_D0.285920.778
68_I71_F0.285780.778
195_F199_F0.285520.777
77_Y83_A0.284570.775
192_I198_A0.283660.772
151_F155_G0.283580.772
257_F261_V0.282610.769
41_D45_Y0.282550.769
273_I278_L0.28230.768
181_N269_D0.281920.767
272_V277_C0.281490.766
80_G84_R0.28080.764
129_P133_Y0.280480.763
117_Q128_L0.280040.762
192_I269_D0.279460.761
122_I125_K0.278620.758
219_M223_L0.278240.757
180_P269_D0.278230.757
102_I147_I0.278210.757
244_A295_T0.277930.756
154_S157_S0.27760.756
274_S281_F0.277210.754
180_P195_F0.276230.752
21_I24_I0.275370.749
106_E201_G0.274760.748
97_W101_F0.274220.746
189_P197_L0.27420.746
72_P77_Y0.274080.746
105_I249_S0.273070.743
20_V24_I0.272970.743
249_S252_C0.27270.742
30_I34_I0.272020.740
192_I197_L0.271910.740
164_Y171_E0.271130.738
47_L111_C0.270410.736
270_A274_S0.269260.733
270_A275_E0.268980.732
257_F260_V0.268930.732
290_I294_I0.267740.729
295_T298_P0.267110.727
146_F150_C0.267030.727
250_S254_L0.266950.727
299_Y302_F0.266740.726
134_I137_Y0.266590.726
209_F217_F0.26630.725
213_T220_L0.265880.724
273_I279_A0.265880.724
96_I100_L0.265520.723
111_C242_L0.265240.722
202_G206_F0.265180.722
272_V275_E0.264650.720
237_E297_P0.26350.717
30_I55_T0.263330.717
58_D284_H0.263010.716
291_V295_T0.262910.716
178_S195_F0.262750.715
75_A78_C0.26240.714
288_N296_T0.262350.714
275_E281_F0.261980.713
179_L196_I0.261580.712
178_S197_L0.261570.712
275_E278_L0.26140.711
117_Q121_R0.261090.711
98_I101_F0.260980.710
160_E163_E0.260640.709
30_I33_I0.260340.709
189_P198_A0.259880.707
33_I40_L0.259580.707
66_Q69_P0.259570.706
220_L238_A0.258490.704
128_L136_F0.257890.702
85_Y96_I0.257470.701
256_P260_V0.257160.700
156_M159_E0.256530.698
276_I279_A0.256520.698
180_P268_E0.255390.695
72_P75_A0.255060.694
269_D274_S0.254350.692
38_P41_D0.253810.691
80_G83_A0.253790.691
145_F149_I0.253760.691
29_G33_I0.253620.690
64_L96_I0.253520.690
191_F271_Q0.253220.689
65_M69_P0.251880.686
98_I148_F0.251680.685
285_S288_N0.250120.681
161_Q164_Y0.250020.680
200_F205_C0.249760.680
275_E282_S0.24940.679
167_E178_S0.249310.679
192_I265_F0.249070.678
106_E144_P0.248420.676
71_F74_P0.248280.676
60_H96_I0.247160.673
194_F199_F0.246670.671
30_I56_L0.246570.671
179_L267_F0.246530.671
37_S42_N0.246450.671
160_E170_P0.246270.670
178_S269_D0.246080.670
170_P275_E0.245570.668
190_W270_A0.245440.668
37_S47_L0.245390.668
66_Q282_S0.245320.668
142_L145_F0.245070.667
226_K233_Q0.244810.666
209_F246_F0.244720.666
191_F269_D0.244450.665
271_Q280_I0.243950.664
98_I255_P0.243610.663
121_R215_D0.243560.663
103_F140_C0.24320.662
178_S267_F0.243180.662
200_F204_L0.24210.659
119_I122_I0.241380.657
272_V279_A0.240750.655
103_F141_I0.240710.655
239_V243_I0.239980.653
95_T149_I0.239940.653
169_Y180_P0.239920.653
150_C154_S0.239760.653
199_F205_C0.239670.652
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA0.9341000.082
3vw7A0.9341000.141
3oduA0.91751000.141
2rh1A0.92081000.146
3emlA0.95051000.148
4eiyA0.95051000.164
4dklA0.92411000.165
3rzeA0.92081000.17
3v2yA0.89771000.172
3uonA0.91751000.175

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