GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
FIST_C - FIST C domain
Pfam: PF10442 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 136
Sequences: 703
Seq/Len: 5.17
HH_delta: 0.902 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
44_D47_D0.290143.004
3_E48_G0.260442.697
44_D49_S0.25072.596
5_Y25_P0.249382.582
26_L62_V0.249012.578
92_L125_I0.170121.761
39_S98_G0.167811.737
5_Y50_L0.166991.729
38_R54_G0.162811.686
127_F130_Y0.162671.684
57_P60_S0.161711.674
94_F129_T0.157121.627
96_C132_E0.152111.575
92_L104_G0.143441.485
96_C99_R0.143161.482
38_R95_S0.141421.464
37_I99_R0.13871.436
72_I103_L0.136451.413
38_R99_R0.135071.399
6_A11_I0.134671.394
78_E81_E0.131321.360
28_I38_R0.130541.352
95_S99_R0.130271.349
44_D51_T0.128051.326
29_E34_Y0.125081.295
27_G67_G0.12261.269
4_V8_Y0.121831.261
2_L6_A0.118181.224
19_S92_L0.117431.216
38_R96_C0.115521.196
97_I101_L0.115471.196
76_A83_A0.115451.195
95_S127_F0.114181.182
25_P72_I0.11411.181
79_A83_A0.114021.181
69_P92_L0.113211.172
53_A95_S0.113071.171
73_I103_L0.112061.160
74_E78_E0.109181.130
98_G128_Y0.108771.126
39_S130_Y0.107681.115
3_E112_E0.10741.112
39_S53_A0.107171.110
90_G123_P0.106761.105
9_L20_V0.106351.101
39_S97_I0.106321.101
110_E113_A0.103451.071
12_E19_S0.103021.067
76_A103_L0.099861.034
16_E19_S0.099811.033
21_V50_L0.09961.031
115_Q124_F0.099271.028
3_E78_E0.098881.024
127_F132_E0.098441.019
128_Y135_P0.09590.993
87_P115_Q0.095470.988
4_V7_E0.09480.982
89_E118_L0.094750.981
33_G92_L0.094370.977
110_E134_G0.094280.976
25_P54_G0.093880.972
98_G134_G0.093450.968
115_Q119_G0.092650.959
60_S128_Y0.092310.956
33_G82_K0.091990.952
32_G47_D0.091130.944
5_Y72_I0.091070.943
79_A103_L0.0910.942
81_E112_E0.090980.942
26_L52_F0.090760.940
9_L18_P0.090450.937
37_I93_I0.090250.934
28_I52_F0.090230.934
16_E68_D0.090210.934
41_L53_A0.090070.933
75_S79_A0.089850.930
20_V24_F0.089820.930
74_E77_E0.089470.926
32_G58_E0.089260.924
42_A51_T0.089070.922
77_E117_I0.088980.921
100_R127_F0.088620.918
95_S98_G0.088450.916
99_R127_F0.08820.913
47_D116_E0.088070.912
54_G95_S0.088040.912
107_F128_Y0.087930.910
83_A93_I0.087640.907
97_I128_Y0.08750.906
64_L79_A0.086440.895
119_G122_A0.086020.891
115_Q123_P0.085710.887
88_P92_L0.085320.883
8_Y11_I0.085280.883
75_S103_L0.085270.883
99_R132_E0.085220.882
71_D107_F0.084760.878
111_L117_I0.084480.875
80_L117_I0.084230.872
81_E119_G0.084230.872
33_G111_L0.084120.871
77_E85_G0.083950.869
99_R126_G0.08360.866
32_G108_D0.083440.864
4_V18_P0.083430.864
76_A118_L0.083230.862
53_A97_I0.083030.860
91_A118_L0.082990.859
5_Y21_V0.082780.857
70_E109_E0.082130.850
9_L99_R0.082050.850
48_G84_P0.081840.847
40_P52_F0.081750.846
43_I59_G0.081740.846
43_I97_I0.081660.846
2_L104_G0.081380.843
82_K118_L0.081350.842
95_S128_Y0.081240.841
53_A98_G0.081230.841
68_D71_D0.081180.841
95_S126_G0.080720.836
6_A17_F0.080540.834
5_Y67_G0.080530.834
14_E108_D0.080420.833
95_S100_R0.07970.825
60_S75_S0.079450.823
113_A116_E0.07910.819
7_E116_E0.078710.815
23_S94_F0.078640.814
39_S128_Y0.078640.814
2_L41_L0.078580.814
23_S43_I0.07830.811
17_F21_V0.078170.809
119_G124_F0.078030.808
73_I123_P0.077540.803
38_R133_I0.077440.802
28_I133_I0.077130.799
53_A128_Y0.077130.799
1_A5_Y0.076510.792
97_I130_Y0.076420.791
67_G76_A0.076320.790
124_F133_I0.076240.789
77_E83_A0.076090.788
38_R44_D0.075770.785
5_Y24_F0.075760.784
11_I15_E0.075750.784
23_S109_E0.07530.780
20_V88_P0.07510.778
27_G134_G0.0750.777
82_K115_Q0.074890.775
76_A79_A0.074640.773
37_I97_I0.074590.772
85_G118_L0.074570.772
74_E112_E0.074550.772
23_S98_G0.074210.768
14_E69_P0.074110.767
27_G79_A0.0740.766
128_Y134_G0.073870.765
57_P62_V0.073740.764
1_A101_L0.073510.761
100_R130_Y0.073490.761
40_P123_P0.073440.760
6_A63_Q0.073220.758
10_G83_A0.073090.757
7_E81_E0.072930.755
72_I92_L0.07280.754
45_P48_G0.072790.754
7_E47_D0.072690.753
12_E31_G0.07250.751
24_F35_F0.072380.749
56_V60_S0.072330.749
70_E112_E0.072090.746
28_I35_F0.072070.746
15_E82_K0.072020.746
90_G125_I0.071820.744
81_E91_A0.071680.742
55_D128_Y0.071570.741
7_E69_P0.071540.741
24_F61_E0.071540.741
77_E81_E0.071440.740
13_S20_V0.071260.738
100_R111_L0.071180.737
5_Y49_S0.070720.732
74_E81_E0.07070.732
64_L83_A0.070680.732
13_S70_E0.070460.730
114_F117_I0.07030.728
58_E103_L0.070240.727
38_R53_A0.070120.726
18_P97_I0.070090.726
41_L128_Y0.06990.724
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3istA0.742638.90.902
2jfzA0.705938.70.902
2dwuA0.757430.30.908
3pegA0.610326.80.91
2ohoA0.8088200.915
1dquA0.948518.80.916
3u55A0.610317.10.917
1zuwA0.7516.20.918
2gzmA0.727914.40.92
3sr3A0.661812.60.922
If you are interested in a protein containing this domain,
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