GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
CLTH - CTLHCRA C-terminal to LisH motif domain
Pfam: PF10607 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 145
Sequences: 966
Seq/Len: 6.66
HH_delta: 0.855 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
55_D58_E0.327592.974
24_L114_F0.261332.373
20_A42_L0.246542.238
12_I114_F0.241242.190
16_D19_P0.23882.168
18_D46_Q0.227272.063
5_R115_N0.216051.961
50_L59_A0.215891.960
63_A82_M0.21571.958
45_Q49_E0.212661.931
44_C81_L0.208741.895
11_A19_P0.204271.854
41_E113_E0.2021.834
12_I17_I0.201671.831
15_G107_R0.198951.806
10_Q14_N0.197551.793
49_E52_R0.191651.740
49_E107_R0.191161.735
11_A16_D0.18711.699
80_K100_E0.185961.688
46_Q66_H0.174661.586
129_P133_I0.174021.580
115_N119_L0.171831.560
45_Q110_L0.167731.523
5_R119_L0.16361.485
45_Q106_R0.162361.474
43_R62_Y0.153381.392
136_A139_S0.151241.373
19_P22_E0.143911.307
96_S100_E0.143911.307
89_D92_E0.143591.304
67_L78_L0.143011.298
13_L108_E0.141351.283
128_S131_E0.140841.279
39_E43_R0.138971.262
129_P136_A0.136151.236
114_F137_G0.134271.219
86_A90_P0.128331.165
75_L79_K0.12721.155
114_F118_I0.126851.152
61_E105_E0.124831.133
23_W27_N0.123191.118
135_K139_S0.122931.116
48_I52_R0.122711.114
98_Y101_L0.121191.100
42_L46_Q0.11861.077
130_L137_G0.117861.070
98_Y102_L0.117511.067
97_P132_V0.116221.055
15_G49_E0.115031.044
44_C77_E0.114931.043
77_E80_K0.114321.038
5_R118_I0.113491.030
40_F44_C0.113381.029
58_E72_D0.111981.017
16_D26_E0.111961.016
25_N78_L0.111831.015
129_P139_S0.108090.981
23_W137_G0.108040.981
96_S99_K0.107390.975
53_E92_E0.107050.972
8_I17_I0.1070.971
38_L113_E0.106850.970
115_N122_Y0.106660.968
22_E25_N0.105790.960
23_W114_F0.105610.959
45_Q107_R0.10460.950
11_A112_E0.104390.948
45_Q52_R0.104350.947
57_M76_E0.10390.943
61_E64_R0.10260.931
12_I42_L0.101760.924
29_P32_L0.101440.921
54_G88_P0.101090.918
87_Y99_K0.100710.914
62_Y66_H0.100640.914
84_L102_L0.099980.908
54_G58_E0.099170.900
45_Q59_A0.098960.898
71_N83_S0.098840.897
5_R32_L0.098810.897
51_L79_K0.097750.887
14_N72_D0.097530.885
107_R136_A0.097210.883
134_L138_L0.096950.880
38_L42_L0.096760.878
14_N88_P0.096360.875
132_V138_L0.095930.871
7_K26_E0.094950.862
47_F82_M0.09470.860
59_A63_A0.094120.854
56_I65_K0.093880.852
25_N72_D0.093830.852
86_A106_R0.093130.845
28_F31_L0.092920.844
48_I116_S0.092690.841
5_R28_F0.092270.838
14_N112_E0.091830.834
131_E135_K0.091820.834
100_E105_E0.091690.832
33_K65_K0.091630.832
34_R73_E0.091410.830
100_E112_E0.091390.830
90_P108_E0.091290.829
45_Q82_M0.091250.828
48_I85_L0.091250.828
11_A113_E0.091170.828
78_L97_P0.09040.821
12_I24_L0.090180.819
124_L137_G0.090050.818
12_I111_A0.089860.816
64_R136_A0.08970.814
60_I129_P0.089590.813
30_E104_P0.08930.811
44_C131_E0.089010.808
31_L36_S0.088930.807
48_I72_D0.087990.799
7_K61_E0.087950.798
129_P137_G0.087920.798
16_D97_P0.087750.797
72_D76_E0.087720.796
70_F132_V0.08770.796
87_Y98_Y0.08760.795
38_L120_K0.087550.795
60_I139_S0.087550.795
112_E126_K0.087490.794
10_Q82_M0.087440.794
68_S75_L0.087360.793
106_R134_L0.087280.792
52_R101_L0.087210.792
76_E104_P0.087170.791
128_S136_A0.086910.789
40_F67_L0.086790.788
45_Q137_G0.086620.786
72_D109_E0.086410.784
25_N32_L0.086340.784
26_E84_L0.086260.783
4_E71_N0.085870.780
117_A128_S0.085640.777
38_L41_E0.085260.774
17_I119_L0.085210.774
134_L139_S0.08520.773
11_A78_L0.085120.773
20_A31_L0.084610.768
78_L84_L0.084530.767
60_I75_L0.08440.766
45_Q129_P0.084370.766
29_P57_M0.083730.760
32_L115_N0.083680.760
70_F92_E0.083640.759
133_I136_A0.083560.759
11_A23_W0.083490.758
117_A123_G0.083380.757
128_S133_I0.083280.756
107_R118_I0.082980.753
22_E27_N0.082760.751
18_D53_E0.082750.751
47_F84_L0.082740.751
81_L119_L0.082490.749
31_L97_P0.082340.748
47_F67_L0.08230.747
52_R102_L0.082140.746
10_Q22_E0.082010.745
9_R115_N0.081990.744
112_E116_S0.081970.744
19_P23_W0.081840.743
115_N118_I0.081680.742
54_G109_E0.081190.737
37_S43_R0.08110.736
36_S47_F0.0810.735
132_V137_G0.080960.735
65_K112_E0.080920.735
23_W31_L0.080860.734
109_E113_E0.080630.732
111_A119_L0.080550.731
17_I42_L0.080480.731
43_R52_R0.080470.731
62_Y83_S0.080470.731
39_E137_G0.080370.730
45_Q63_A0.080220.728
22_E56_I0.080120.727
41_E44_C0.080110.727
77_E81_L0.079930.726
16_D39_E0.079820.725
70_F78_L0.079770.724
71_N90_P0.079730.724
54_G97_P0.07960.723
98_Y107_R0.079560.722
78_L88_P0.079440.721
58_E109_E0.079360.720
63_A67_L0.079280.720
87_Y96_S0.079240.719
80_K83_S0.078910.716
107_R114_F0.07890.716
36_S39_E0.078760.715
132_V135_K0.078760.715
34_R126_K0.078580.713
4_E92_E0.078490.713
22_E103_S0.078280.711
4_E13_L0.078260.710
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2nxpA0.972489.90.855
2j49A0.93187.40.862
2j4bA0.937986.80.863
4jspB0.937945.40.898
4jsnB0.937945.40.898
2dnaA0.248325.70.91
1hw1A0.551720.90.914
1ihgA0.675916.50.918
4b4tR0.896615.90.918
4houA0.669150.919
If you are interested in a protein containing this domain,
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