GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2512 - Protein of unknown function (DUF2512)
Pfam: PF10710 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 136
Sequences: 899
Seq/Len: 6.61
HH_delta: 0.904 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
59_I62_T0.518853.067
21_I98_I0.413092.442
57_G65_D0.408222.413
57_G60_V0.400462.367
57_G62_T0.384522.273
73_I98_I0.355942.104
43_V72_V0.333681.972
73_I94_S0.323771.914
43_V47_I0.291091.721
71_L74_W0.286941.696
19_Y33_I0.282941.672
22_L90_A0.278371.645
88_A92_L0.276381.634
43_V76_M0.27591.631
101_G105_F0.273251.615
52_I65_D0.269181.591
49_D54_P0.253751.500
18_L36_I0.252461.492
21_I97_L0.251311.486
57_G64_A0.247671.464
73_I85_V0.246541.457
10_K106_H0.244191.443
22_L97_L0.237791.406
50_L53_L0.237441.404
39_V76_M0.236791.400
70_F92_L0.23611.396
15_I34_L0.229591.357
66_F92_L0.225361.332
64_A67_G0.220671.304
90_A94_S0.214261.267
21_I74_W0.214021.265
17_V105_F0.213461.262
18_L94_S0.207751.228
48_G99_G0.206341.220
88_A91_A0.206161.219
11_F34_L0.197941.170
35_L93_L0.196381.161
16_I23_G0.195781.157
7_L38_L0.193611.144
44_A69_A0.188531.114
70_F95_A0.182971.082
22_L94_S0.17961.062
48_G52_I0.178661.056
48_G65_D0.177821.051
91_A95_A0.176931.046
77_G85_V0.175961.040
25_F94_S0.17511.035
18_L98_I0.174861.034
85_V94_S0.173461.025
40_L76_M0.170991.011
26_F86_S0.169971.005
32_D36_I0.169151.000
45_Y70_F0.169091.000
19_Y41_T0.168910.998
15_I61_A0.16580.980
63_I67_G0.164190.971
70_F73_I0.16360.967
17_V21_I0.163560.967
25_F98_I0.161550.955
16_I58_N0.161060.952
11_F42_V0.160730.950
10_K101_G0.160710.950
66_F69_A0.160410.948
30_F33_I0.158420.936
17_V20_I0.157670.932
80_L83_N0.156970.928
72_V76_M0.156870.927
77_G84_Y0.156830.927
87_I90_A0.154760.915
107_R111_R0.154520.913
13_M102_E0.15390.910
60_V68_L0.153830.909
94_S98_I0.151960.898
39_V99_G0.149070.881
55_R65_D0.148820.880
5_K8_L0.148740.879
15_I33_I0.147730.873
14_T73_I0.14750.872
29_S77_G0.147340.871
51_F54_P0.145790.862
26_F31_G0.145420.860
102_E106_H0.144150.852
33_I37_S0.14280.844
92_L95_A0.142190.840
65_D106_H0.141990.839
104_F107_R0.141660.837
97_L101_G0.141380.836
41_T102_E0.137580.813
18_L21_I0.137550.813
31_G100_V0.136670.808
45_Y106_H0.136470.807
19_Y27_G0.136070.804
33_I36_I0.135550.801
67_G104_F0.135350.800
25_F73_I0.134760.797
8_L12_V0.134070.792
74_W78_Y0.133740.791
51_F55_R0.133250.788
86_S90_A0.131810.779
28_A84_Y0.131680.778
32_D80_L0.131470.777
16_I81_T0.131420.777
53_L57_G0.13120.776
27_G33_I0.131150.775
98_I101_G0.130640.772
48_G64_A0.130290.770
66_F99_G0.128410.759
103_Y107_R0.12810.757
34_L38_L0.128090.757
42_V46_L0.127720.755
66_F95_A0.126970.751
37_S96_V0.126910.750
36_I83_N0.126770.749
18_L76_M0.126610.748
49_D55_R0.126330.747
7_L53_L0.125420.741
17_V31_G0.125090.739
7_L10_K0.124740.737
16_I103_Y0.123550.730
28_A82_G0.123160.728
34_L80_L0.121750.720
50_L79_I0.121710.719
14_T24_L0.120920.715
75_L101_G0.120750.714
25_F77_G0.120030.710
74_W94_S0.119050.704
36_I76_M0.118650.701
59_I64_A0.118440.700
47_I77_G0.118360.700
15_I30_F0.117970.697
94_S103_Y0.117870.697
27_G104_F0.117850.697
93_L96_V0.11780.696
66_F70_F0.117690.696
6_A10_K0.117130.692
65_D102_E0.116920.691
50_L56_T0.116470.688
52_I55_R0.115850.685
50_L84_Y0.115520.683
65_D96_V0.115170.681
32_D99_G0.114780.678
50_L67_G0.114670.678
58_N64_A0.114610.677
74_W87_I0.113140.669
55_R64_A0.113080.668
9_I42_V0.112910.667
38_L97_L0.112590.666
22_L93_L0.112580.665
70_F88_A0.112490.665
51_F72_V0.112290.664
99_G110_L0.111990.662
28_A95_A0.111860.661
106_H110_L0.111310.658
17_V108_Y0.111180.657
11_F14_T0.110160.651
17_V101_G0.109580.648
14_T41_T0.109230.646
53_L110_L0.108640.642
9_I100_V0.108420.641
39_V80_L0.107850.638
40_L80_L0.107310.634
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2kv5A0.242646.40.904
3dh4A0.889780.932
3rlfF0.83097.50.933
4j05A0.96326.60.934
4gc0A0.99266.30.935
3zuxA0.94126.50.935
2oarA0.86035.40.937
4gipD0.34564.90.938
4eneA0.90444.70.938
1aym10.33824.30.94
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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