GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2723 - Protein of unknown function (DUF2723)
Pfam: PF11028 (v26) Consensus Sequence
Clan: CL0111
Length: 178
Sequences: 1316
Seq/Len: 7.39
HH_delta: 0.643 (11Mar13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
62_I85_G0.445122.926
55_I89_A0.443332.914
108_Y152_H0.423442.783
57_F117_L0.405362.664
62_I88_G0.347642.285
53_L113_L0.33942.231
54_T116_A0.325692.141
64_R127_E0.318362.093
142_A146_G0.316472.080
117_L144_L0.313562.061
57_F113_L0.270461.778
121_L137_W0.269981.775
121_L144_L0.269141.769
148_S155_N0.268661.766
59_F89_A0.266441.751
114_F151_V0.265061.742
160_P163_A0.263041.729
92_F98_F0.257661.694
50_S113_L0.252251.658
67_R84_A0.247541.627
58_L88_G0.243881.603
114_F144_L0.236911.557
39_I42_R0.236861.557
58_L92_F0.231351.521
60_W120_W0.23081.517
64_R124_R0.227661.496
61_I123_L0.226271.487
107_V152_H0.215091.414
63_T85_G0.206291.356
108_Y111_N0.201761.326
150_G153_L0.198821.307
85_G89_A0.197941.301
61_I116_A0.196291.290
114_F147_L0.193611.273
50_S110_L0.193041.269
54_T113_L0.190661.253
23_F107_V0.188721.240
55_I92_F0.183511.206
111_N153_L0.181331.192
16_H111_N0.179971.183
55_I93_A0.176641.161
22_L151_V0.173831.143
15_P107_V0.172721.135
46_M50_S0.168961.111
23_F27_G0.168911.110
67_R127_E0.168641.108
63_T68_K0.166291.093
120_W124_R0.163341.074
49_L53_L0.161831.064
111_N152_H0.15931.047
24_T44_N0.157211.033
121_L140_L0.157061.032
44_N152_H0.155241.020
56_L60_W0.153611.010
22_L25_L0.152971.005
59_F63_T0.152691.004
26_L110_L0.15080.991
24_T28_R0.148480.976
49_L136_R0.147420.969
55_I98_F0.146870.965
146_G150_G0.146780.965
156_L160_P0.146560.963
110_L114_F0.143560.944
85_G88_G0.143020.940
68_K83_G0.142580.937
23_F110_L0.14210.934
21_P25_L0.141670.931
51_S55_I0.140920.926
25_L153_L0.140710.925
118_V145_C0.13860.911
122_L126_E0.138380.910
40_A44_N0.138220.909
50_S114_F0.137890.906
51_S98_F0.137550.904
49_L57_F0.136770.899
30_F33_L0.13670.899
154_L158_A0.135740.892
51_S102_A0.135630.892
112_S124_R0.135450.890
25_L28_R0.135170.888
61_I119_F0.133510.878
53_L57_F0.132660.872
95_S157_L0.13260.872
17_P153_L0.131930.867
148_S152_H0.131810.866
17_P101_Q0.131720.866
63_T67_R0.131210.862
60_W63_T0.130940.861
121_L141_I0.130360.857
47_S105_A0.12970.853
93_A139_L0.129380.850
51_S93_A0.129120.849
109_A144_L0.129090.849
144_L147_L0.129080.848
65_L127_E0.1290.848
161_A164_L0.128760.846
125_W141_I0.128560.845
15_P152_H0.128280.843
54_T164_L0.128180.843
145_C149_L0.128060.842
23_F106_E0.127170.836
17_P152_H0.1270.835
41_F45_L0.126960.835
52_A56_L0.126850.834
113_L117_L0.12660.832
125_W138_L0.126340.830
16_H153_L0.125810.827
139_L142_A0.125480.825
24_T153_L0.12380.814
54_T57_F0.123350.811
37_G42_R0.122110.803
88_G92_F0.121760.800
51_S95_S0.121540.799
65_L87_V0.120840.794
62_I66_L0.120410.791
24_T148_S0.120390.791
96_D153_L0.120050.789
59_F85_G0.11890.782
111_N155_N0.118640.780
153_L156_L0.117790.774
16_H107_V0.11710.770
24_T107_V0.116250.764
16_H156_L0.116140.763
101_Q104_E0.115990.762
14_V113_L0.115770.761
47_S103_V0.115070.756
44_N48_A0.114570.753
25_L29_L0.114540.753
124_R127_E0.113890.749
106_E111_N0.11370.747
57_F116_A0.113630.747
128_E134_S0.113620.747
139_L143_F0.113130.744
108_Y146_G0.11270.741
14_V142_A0.111960.736
24_T106_E0.111920.736
15_P24_T0.111910.736
68_K90_L0.111510.733
15_P27_G0.110930.729
51_S109_A0.110030.723
22_L33_L0.109770.722
155_N163_A0.109710.721
123_L126_E0.109580.720
134_S144_L0.109180.718
22_L28_R0.108850.715
148_S151_V0.108520.713
134_S137_W0.10850.713
54_T112_S0.108380.712
54_T92_F0.108080.710
57_F104_E0.108080.710
24_T47_S0.107690.708
149_L159_I0.107650.708
47_S109_A0.107280.705
29_L128_E0.106990.703
105_A108_Y0.106820.702
27_G103_V0.106750.702
24_T142_A0.105180.691
58_L61_I0.105140.691
87_V134_S0.105110.691
38_N41_F0.105040.690
51_S101_Q0.104890.689
136_R139_L0.104840.689
147_L151_V0.104480.687
87_V90_L0.104430.686
47_S50_S0.104410.686
158_A165_V0.103640.681
24_T151_V0.103560.681
48_A93_A0.103550.681
86_L117_L0.103460.680
25_L152_H0.102870.676
57_F60_W0.102630.675
42_R59_F0.102560.674
24_T154_L0.102250.672
122_L145_C0.102230.672
83_G86_L0.101620.668
68_K88_G0.101520.667
67_R85_G0.101290.666
115_T158_A0.101190.665
106_E152_H0.100990.664
68_K136_R0.100780.662
65_L123_L0.100720.662
84_A160_P0.100310.659
60_W64_R0.100270.659
117_L120_W0.100020.657
29_L119_F0.10.657
54_T98_F0.099280.653
83_G143_F0.099280.653
138_L145_C0.099160.652
38_N45_L0.099140.652
124_R128_E0.098940.650
59_F94_F0.098910.650
118_V121_L0.09830.646
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3rceA0.887698.90.643
3hheA0.31467.50.931
3uw1A0.31467.20.932
2f8mA0.32585.40.935
2jwaA0.24724.50.937
2x3lA0.32583.60.94
1wazA0.22473.10.942
2ks1B0.24722.90.942
2dm7A0.19662.50.944
2l2tA0.24722.20.946
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