GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2910 - Protein of unknown function (DUF2910)
Pfam: PF11139 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0549
Length: 214
Sequences: 8569
Seq/Len: 40.04
HH_delta: 0.925 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
40_L115_F1.832715.698
83_A202_L1.124633.497
84_V88_R0.805172.503
80_L205_G0.797472.479
73_L77_V0.760132.363
69_G72_Q0.749462.330
76_G205_G0.745742.319
76_G209_L0.736222.289
83_A198_A0.725912.257
192_H195_Q0.717252.230
156_Y160_A0.68742.137
80_L202_L0.672122.090
199_V203_I0.657932.046
36_A115_F0.62981.958
191_R195_Q0.621211.931
18_A34_F0.600391.867
87_W198_A0.598811.862
44_A119_F0.579731.802
73_L209_L0.5471.701
73_L76_G0.538491.674
30_N114_A0.534281.661
23_S31_L0.532291.655
33_A111_P0.525781.635
80_L84_V0.514071.598
112_G116_W0.510661.588
41_G119_F0.502781.563
41_G123_L0.500331.556
116_W120_V0.490071.524
145_S148_T0.488231.518
34_F118_G0.484951.508
81_L85_R0.4761.480
192_H196_I0.472411.469
42_Y122_G0.469891.461
37_G115_F0.46441.444
78_L81_L0.463591.441
177_R181_W0.461831.436
31_L35_L0.451521.404
110_S113_G0.450271.400
15_I38_W0.447521.391
66_P70_W0.444791.383
22_L26_R0.441331.372
146_P149_Q0.44031.369
68_V72_Q0.43831.363
198_A202_L0.434831.352
69_G73_L0.43141.341
66_P69_G0.43041.338
87_W202_L0.427011.328
70_W74_V0.425531.323
85_R88_R0.413621.286
119_F123_L0.412931.284
83_A87_W0.412661.283
11_S16_V0.41021.275
47_L51_F0.409991.275
87_W195_Q0.40651.264
115_F119_F0.396321.232
37_G118_G0.395361.229
83_A205_G0.395361.229
15_I122_G0.392191.219
147_G150_V0.391791.218
41_G122_G0.388931.209
67_V70_W0.384731.196
78_L82_L0.384251.195
177_R180_P0.380881.184
33_A114_A0.378141.176
170_A174_A0.377981.175
19_V23_S0.376681.171
22_L34_F0.376391.170
15_I42_Y0.37011.151
45_V122_G0.366911.141
42_Y128_T0.366511.139
179_E183_E0.360341.120
195_Q199_V0.358931.116
49_L129_M0.35431.102
202_L205_G0.352971.097
168_L172_L0.350631.090
46_G132_Y0.34361.068
167_P171_Y0.342461.065
42_Y45_V0.341991.063
203_I207_L0.341231.061
31_L172_L0.338881.054
35_L39_F0.336931.048
156_Y159_I0.335531.043
13_L125_N0.328031.020
70_W73_L0.327431.018
15_I121_L0.326331.015
32_L35_L0.325541.012
77_V81_L0.325311.011
202_L206_A0.322491.003
113_G116_W0.320450.996
18_A22_L0.320290.996
40_L44_A0.319590.994
166_L170_A0.318940.992
172_L175_P0.318880.991
52_G57_P0.316390.984
32_L36_A0.316370.984
134_A138_I0.313670.975
180_P184_R0.312710.972
77_V80_L0.312280.971
26_R30_N0.311260.968
19_V34_F0.310340.965
76_G80_L0.304670.947
42_Y132_Y0.303790.944
18_A121_L0.302830.942
88_R91_P0.302670.941
43_L157_C0.299880.932
55_A59_G0.298450.928
178_A182_L0.298010.927
145_S149_Q0.295480.919
38_W42_Y0.293450.912
81_L84_V0.293030.911
29_R111_P0.292870.911
35_L172_L0.291590.907
17_I21_L0.291570.907
169_L173_V0.290840.904
30_N33_A0.289210.899
9_A16_V0.2860.889
121_L124_A0.284860.886
144_L149_Q0.284530.885
22_L117_L0.284310.884
204_V207_L0.281330.875
28_R173_V0.280960.874
71_L75_L0.280060.871
92_R95_P0.279850.870
190_R194_R0.278720.867
19_V168_L0.277190.862
45_V123_L0.276220.859
124_A133_L0.276110.858
167_P170_A0.275130.855
23_S172_L0.274910.855
188_W192_H0.271920.845
174_A177_R0.271760.845
151_V154_V0.270670.842
78_L127_K0.269130.837
34_F121_L0.267240.831
59_G64_P0.266950.830
22_L25_P0.266820.830
129_M133_L0.266540.829
152_A155_V0.266210.828
157_C160_A0.265650.826
33_A36_A0.264650.823
42_Y118_G0.264370.822
132_Y136_I0.263790.820
28_R169_L0.26250.816
12_P127_K0.26240.816
150_V153_L0.2610.811
141_A144_L0.260860.811
117_L120_V0.260440.810
42_Y124_A0.260120.809
38_W122_G0.26010.809
40_L119_F0.259750.808
16_V121_L0.259330.806
25_P29_R0.259330.806
165_L169_L0.25880.805
29_R33_A0.258410.803
9_A159_I0.257830.802
187_S190_R0.256550.798
141_A149_Q0.256410.797
42_Y46_G0.255060.793
189_L193_S0.255060.793
51_F55_A0.253940.790
64_P68_V0.252810.786
8_D131_P0.252170.784
21_L24_R0.250770.780
171_Y175_P0.249630.776
15_I18_A0.249180.775
45_V49_L0.248070.771
16_V168_L0.24760.770
86_V197_L0.24640.766
166_L169_L0.246050.765
186_R191_R0.245530.763
80_L209_L0.245060.762
196_I199_V0.244990.762
131_P135_A0.24460.760
171_Y174_A0.244470.760
11_S14_P0.2440.759
57_P64_P0.243880.758
9_A128_T0.243790.758
150_V154_V0.242330.753
168_L171_Y0.241840.752
8_D135_A0.241350.750
41_G127_K0.240650.748
28_R32_L0.239430.744
178_A181_W0.238980.743
193_S197_L0.238350.741
179_E182_L0.238340.741
17_I197_L0.236680.736
201_L208_L0.236550.735
136_I140_A0.236440.735
168_L175_P0.235320.732
7_V131_P0.234670.730
167_P172_L0.234130.728
16_V171_Y0.233870.727
19_V38_W0.233790.727
114_A117_L0.233750.727
54_D57_P0.232220.722
44_A123_L0.231840.721
188_W191_R0.231310.719
90_R195_Q0.231140.719
175_P178_A0.230150.716
197_L201_L0.229680.714
52_G55_A0.229120.712
135_A139_I0.228780.711
82_L86_V0.228490.710
38_W128_T0.228470.710
9_A15_I0.227710.708
26_R29_R0.227110.706
16_V20_L0.226510.704
90_R93_P0.226070.703
65_S69_G0.22470.699
14_P125_N0.223970.696
57_P68_V0.222770.693
43_L154_V0.221650.689
167_P175_P0.221570.689
8_D128_T0.22140.688
15_I128_T0.221190.688
84_V202_L0.220250.685
93_P96_P0.220230.685
49_L140_A0.219750.683
9_A168_L0.21840.679
122_G128_T0.217430.676
198_A201_L0.216510.673
15_I45_V0.216440.673
25_P28_R0.216230.672
14_P127_K0.216120.672
148_T151_V0.21580.671
12_P15_I0.21510.669
37_G119_F0.214820.668
58_S64_P0.214060.666
87_W199_V0.213860.665
126_P130_L0.213020.662
42_Y121_L0.212070.659
173_V182_L0.210630.655
46_G136_I0.209840.652
199_V202_L0.209620.652
9_A19_V0.209440.651
176_E179_E0.208520.648
81_L90_R0.208110.647
45_V129_M0.208070.647
27_P31_L0.20760.645
53_L56_L0.207040.644
9_A38_W0.206450.642
45_V133_L0.206450.642
181_W184_R0.206370.642
10_L167_P0.204940.637
118_G122_G0.204170.635
124_A129_M0.20320.632
165_L168_L0.202110.628
109_A113_G0.201780.627
89_R194_R0.201560.627
18_A21_L0.20140.626
112_G115_F0.201380.626
149_Q153_L0.201040.625
74_V77_V0.200060.622
34_F114_A0.200050.622
54_D58_S0.19950.620
44_A47_L0.199080.619
135_A140_A0.1990.619
39_F42_Y0.198530.617
184_R188_W0.198440.617
153_L156_Y0.198180.616
13_L16_V0.198110.616
64_P67_V0.197720.615
131_P137_A0.197680.615
35_L38_W0.197510.614
34_F38_W0.19590.609
23_S175_P0.195720.609
85_R117_L0.195090.607
42_Y160_A0.1950.606
86_V195_Q0.194440.605
155_V160_A0.194130.604
64_P69_G0.19410.603
80_L83_A0.193830.603
144_L148_T0.193590.602
49_L132_Y0.193490.602
46_G153_L0.193210.601
15_I160_A0.193120.600
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4ainA0.4953110.925
2wswA0.41128.40.929
1pw4A0.45337.70.93
3zuxA0.4725.90.934
2gfpA0.85985.60.934
3o7qA0.90654.70.936
4dx5A0.88794.50.937
3j1zP0.49074.50.937
3h90A0.44864.20.938
3ne5A0.92064.10.938
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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