GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
YflT - Heat induced stress protein YflT
Pfam: PF11181 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 103
Sequences: 930
Seq/Len: 9.03
HH_delta: 0.826 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
56_E60_D0.356232.778
8_N11_E0.340072.652
93_E98_K0.329062.566
26_E29_I0.283692.212
54_S57_S0.249691.947
52_G64_N0.209021.630
9_E13_L0.196381.532
60_D64_N0.186551.455
5_V93_E0.186171.452
60_D71_D0.184351.438
84_E88_E0.178581.393
90_Y100_V0.175391.368
56_E75_S0.174621.362
20_K26_E0.17461.362
6_Y15_A0.172971.349
18_E22_Q0.172681.347
92_E96_Q0.168951.318
52_G75_S0.165421.290
12_A31_V0.163991.279
57_S61_K0.16241.267
13_L17_E0.161531.260
59_W63_K0.158591.237
56_E71_D0.158161.233
56_E61_K0.157911.232
32_V94_L0.157811.231
63_K67_T0.156731.222
55_E59_W0.156641.222
35_D41_R0.155321.211
12_A101_L0.155111.210
61_K65_F0.154711.207
59_W64_N0.150951.177
71_D75_S0.149571.166
78_E83_S0.149461.166
7_D98_K0.148351.157
87_A97_G0.147261.148
20_K25_S0.144951.130
41_R101_L0.143421.119
68_S75_S0.142751.113
19_L24_Y0.142411.111
29_I101_L0.141491.103
91_E95_D0.141481.103
57_S63_K0.139951.091
15_A18_E0.138941.084
89_R93_E0.13811.077
11_E17_E0.13711.069
28_D102_V0.136431.064
44_D84_E0.134681.050
56_E64_N0.132741.035
14_S17_E0.131841.028
15_A65_F0.131381.025
16_I101_L0.131361.024
11_E31_V0.131091.022
3_I102_V0.130871.021
79_S84_E0.128090.999
5_V25_S0.12680.989
33_A40_E0.126190.984
87_A90_Y0.12610.983
60_D66_F0.125550.979
25_S57_S0.125470.979
85_D92_E0.125260.977
4_G83_S0.125090.976
42_L88_E0.124590.972
29_I38_R0.124270.969
10_E14_S0.122230.953
65_F68_S0.121560.948
61_K75_S0.121190.945
30_Y61_K0.119840.935
94_L97_G0.118720.926
39_T43_A0.117870.919
75_S79_S0.117740.918
72_E81_G0.116050.905
77_L81_G0.115930.904
52_G65_F0.115720.902
12_A102_V0.115160.898
66_F70_G0.114160.890
6_Y94_L0.114060.890
74_R91_E0.113090.882
65_F70_G0.112570.878
18_E37_D0.111880.873
14_S40_E0.111610.870
51_V55_E0.111040.866
81_G87_A0.110280.860
47_D82_L0.109840.857
23_G77_L0.109580.855
81_G94_L0.109170.851
30_Y100_V0.107880.841
48_T88_E0.107760.840
27_D48_T0.107710.840
34_K69_G0.107550.839
19_L101_L0.107010.835
30_Y72_E0.1070.834
23_G47_D0.106820.833
7_D25_S0.106610.831
80_L96_Q0.106480.830
61_K70_G0.106090.827
15_A30_Y0.105570.823
81_G84_E0.104160.812
76_K80_L0.10410.812
68_S98_K0.103770.809
18_E21_A0.103750.809
69_G76_K0.103560.808
7_D99_I0.103230.805
87_A93_E0.103030.804
12_A99_I0.103010.803
31_V41_R0.101790.794
10_E17_E0.101710.793
56_E69_G0.101310.790
5_V33_A0.101070.788
56_E72_E0.101070.788
16_I29_I0.100460.783
24_Y101_L0.100350.783
17_E26_E0.100030.780
53_A100_V0.099910.779
83_S92_E0.099820.778
99_I102_V0.099240.774
7_D96_Q0.098880.771
15_A101_L0.098650.769
41_R62_I0.098480.768
48_T68_S0.098170.766
34_K37_D0.09790.764
29_I91_E0.097720.762
51_V76_K0.097630.761
18_E96_Q0.097340.759
58_F62_I0.097310.759
62_I65_F0.096980.756
48_T87_A0.096690.754
59_W67_T0.096190.750
5_V100_V0.096120.750
53_A71_D0.095220.743
61_K85_D0.095070.741
28_D82_L0.095060.741
5_V59_W0.094910.740
29_I72_E0.094530.737
65_F69_G0.094520.737
95_D98_K0.094230.735
34_K63_K0.093810.732
29_I40_E0.09380.732
18_E36_K0.093490.729
60_D63_K0.093030.726
47_D89_R0.092930.725
13_L41_R0.092720.723
48_T86_E0.092440.721
35_D39_T0.091990.717
53_A63_K0.091670.715
73_L81_G0.091590.714
60_D65_F0.091370.713
21_A101_L0.091360.712
30_Y87_A0.091240.712
26_E34_K0.091190.711
46_T78_E0.091120.711
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3pyfA0.456370.60.826
1x60A0.310744.40.851
1utaA0.611737.80.857
2pg9A0.368936.80.858
3k17A0.436927.80.866
4af8A0.970927.20.866
3mosA0.961226.40.867
3l9wA0.883525.10.868
4bgdA0.883523.60.87
3my7A0.961222.20.871
If you are interested in a protein containing this domain,
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