GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF2971 - Protein of unknown function (DUF2971)
Pfam: PF11185 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 90
Sequences: 504
Seq/Len: 5.6
HH_delta: 0.87 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
4_H84_Y0.696125.296
3_R82_W0.460543.504
38_P88_W0.380662.896
4_H82_W0.357972.723
9_H82_W0.309842.357
7_D10_K0.304072.313
3_R84_Y0.297022.260
80_P83_S0.267382.034
3_R9_H0.252691.922
37_Y76_F0.237861.810
1_M4_H0.236751.801
1_M84_Y0.205661.565
13_C82_W0.204031.552
40_I77_F0.183651.397
13_C16_F0.175261.333
83_S86_N0.174871.330
1_M13_C0.169721.291
79_H82_W0.161161.226
1_M75_F0.158731.208
3_R13_C0.145781.109
36_L90_I0.138521.054
36_L88_W0.135161.028
4_H79_H0.13271.010
7_D57_E0.131250.999
4_H9_H0.129030.982
9_H13_C0.128430.977
38_P48_I0.127420.969
4_H16_F0.123780.942
9_H46_Q0.123210.937
6_A9_H0.122230.930
39_V56_S0.121320.923
8_N55_E0.120390.916
40_I83_S0.12010.914
43_D80_P0.119650.910
5_Y78_K0.117890.897
14_I33_E0.116430.886
10_K31_G0.116280.885
6_A35_F0.116030.883
16_F81_A0.113070.860
76_F88_W0.111520.848
30_S36_L0.109770.835
57_E72_K0.108290.824
51_D86_N0.107770.820
31_G86_N0.107460.818
14_I73_I0.10730.816
17_D54_I0.107030.814
1_M15_G0.106230.808
9_H84_Y0.106220.808
25_L29_N0.105790.805
29_N53_I0.10550.803
4_H13_C0.10360.788
16_F76_F0.102530.780
3_R8_N0.102240.778
32_N40_I0.10130.771
4_H88_W0.101240.770
43_D74_S0.101130.769
8_N74_S0.099490.757
71_I86_N0.098430.749
72_K81_A0.096320.733
34_I73_I0.096220.732
28_E31_G0.095870.729
1_M5_Y0.09570.728
3_R81_A0.095650.728
13_C74_S0.095380.726
54_I73_I0.095310.725
25_L43_D0.094940.722
42_D80_P0.09480.721
42_D75_F0.094460.719
42_D73_I0.094130.716
1_M16_F0.093660.713
32_N88_W0.093550.712
40_I45_E0.093370.710
35_F86_N0.093080.708
9_H45_E0.093040.708
6_A34_I0.092660.705
7_D44_E0.091760.698
46_Q50_S0.091680.697
36_L76_F0.091040.693
50_S74_S0.091040.693
76_F81_A0.091040.693
31_G43_D0.090370.688
40_I46_Q0.090250.687
11_G82_W0.090180.686
34_I56_S0.089720.683
1_M82_W0.088570.674
37_Y90_I0.088160.671
1_M78_K0.087990.669
2_W5_Y0.087520.666
34_I70_L0.087370.665
4_H75_F0.087070.662
17_D47_E0.086670.659
32_N35_F0.086480.658
56_S83_S0.086150.655
14_I17_D0.086020.654
39_V44_E0.085090.647
51_D83_S0.084770.645
6_A46_Q0.084710.644
45_E50_S0.084640.644
12_V70_L0.084410.642
25_L31_G0.08430.641
8_N83_S0.084270.641
8_N75_F0.083840.638
12_V79_H0.083830.638
48_I77_F0.083410.635
33_E47_E0.083110.632
12_V90_I0.082470.627
44_E56_S0.082360.627
47_E73_I0.082050.624
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2ztbA113.70.87
3hkwA0.8333120.873
1z3xA0.866780.882
1tulA0.33336.10.888
1eovA0.48894.90.893
2co3A0.78894.70.894
1y6iA0.94.50.895
4i95A0.96674.30.895
2ww9C0.43333.80.898
2xgtA0.48893.80.898
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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