GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF3159 - Protein of unknown function (DUF3159)
Pfam: PF11361 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 187
Sequences: 1151
Seq/Len: 6.16
HH_delta: 0.902 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
105_G115_P0.307872.689
135_W177_S0.281472.458
90_A140_A0.279232.438
79_F155_V0.263892.305
44_W48_R0.253992.218
87_A143_L0.243372.125
75_A155_V0.242742.120
154_S157_A0.237742.076
35_L62_V0.228931.999
173_A177_S0.22491.964
90_A94_L0.223861.955
90_A136_A0.212211.853
133_W136_A0.202911.772
20_A29_P0.198091.730
147_L151_L0.197191.722
142_R166_G0.195511.707
94_L136_A0.19451.699
137_A141_L0.193751.692
175_W178_W0.191061.669
97_V132_T0.179281.566
32_I36_A0.175481.532
96_S104_V0.174941.528
46_L50_E0.162371.418
66_A71_R0.156291.365
98_L132_T0.154711.351
34_A61_G0.15331.339
160_V164_A0.152231.329
14_V163_L0.151611.324
84_W145_V0.148321.295
26_G29_P0.147521.288
134_V173_A0.146571.280
167_W170_F0.146471.279
86_N139_F0.14461.263
43_V47_V0.14451.262
42_V52_V0.143741.255
178_W182_R0.143331.252
89_Y139_F0.142721.246
138_V173_A0.139151.215
143_L147_L0.138691.211
91_V95_V0.1371.196
104_V107_I0.136931.196
94_L133_W0.135781.186
102_P105_G0.135281.181
171_A175_W0.133041.162
68_I71_R0.13261.158
40_V116_T0.131891.152
11_I14_V0.131261.146
63_A66_A0.131161.145
166_G174_L0.130721.142
94_L98_L0.131.135
172_L176_V0.128781.125
133_W137_A0.128211.120
105_G109_G0.127071.110
86_N142_R0.127041.109
153_D157_A0.125541.096
87_A140_A0.125091.092
148_P153_D0.124271.085
130_R133_W0.123551.079
75_A79_F0.123071.075
144_A148_P0.12281.072
97_V133_W0.122161.067
65_S79_F0.120981.057
99_V102_P0.12091.056
92_V95_V0.120431.052
85_T149_L0.120021.048
46_L49_R0.119971.048
158_L161_A0.119891.047
28_T70_W0.119431.043
27_L31_L0.119311.042
94_L137_A0.118811.038
157_A160_V0.118291.033
98_L144_A0.117951.030
93_F96_S0.117931.030
92_V103_L0.117221.024
16_V33_A0.1171.022
89_Y138_V0.116291.016
83_I146_Q0.116251.015
58_G168_P0.116081.014
92_V97_V0.115391.008
103_L107_I0.115281.007
27_L69_A0.115261.007
39_V42_V0.114891.003
80_L151_L0.114230.998
15_L104_V0.113540.992
95_V136_A0.112970.987
106_V132_T0.110550.965
74_S77_D0.110520.965
71_R174_L0.109780.959
60_F144_A0.109680.958
11_I16_V0.109540.957
36_A110_L0.109470.956
78_F150_Y0.108770.950
179_W183_R0.10870.949
171_A184_A0.108510.948
176_V181_V0.108050.944
110_L145_V0.107950.943
156_G172_L0.107880.942
82_G142_R0.107840.942
31_L183_R0.107680.940
70_W85_T0.107410.938
79_F146_Q0.107410.938
87_A130_R0.106790.933
168_P172_L0.106580.931
98_L102_P0.106210.928
180_V183_R0.104940.916
24_T39_V0.104880.916
140_A144_A0.104840.916
103_L136_A0.104640.914
50_E53_Q0.104130.909
81_P146_Q0.104110.909
179_W182_R0.103450.903
11_I15_L0.103360.903
142_R169_L0.103260.902
13_P139_F0.103070.900
95_V174_L0.102670.897
134_V176_V0.102340.894
58_G62_V0.101870.890
161_A165_M0.101790.889
20_A33_A0.101760.889
49_R174_L0.10070.879
116_T130_R0.100510.878
134_V180_V0.100470.877
135_W170_F0.10030.876
60_F145_V0.100030.874
70_W73_G0.100010.873
86_N93_F0.099670.870
101_W174_L0.099670.870
131_A173_A0.099480.869
39_V100_R0.099450.868
144_A176_V0.099380.868
28_T73_G0.099090.865
44_W47_V0.098890.864
93_F104_V0.098890.864
14_V93_F0.098580.861
138_V169_L0.098420.859
14_V30_A0.098030.856
34_A174_L0.097680.853
40_V145_V0.097470.851
97_V119_R0.09690.846
56_L145_V0.096890.846
146_Q162_R0.096790.845
72_T77_D0.096330.841
79_F150_Y0.096280.841
100_R119_R0.096170.840
88_V168_P0.096140.840
13_P38_A0.096010.838
89_Y93_F0.095840.837
39_V88_V0.095610.835
48_R101_W0.095360.833
81_P139_F0.095320.832
14_V18_V0.094670.827
79_F149_L0.094440.825
75_A92_V0.094340.824
130_R176_V0.094330.824
65_S81_P0.094010.821
45_R49_R0.093970.821
56_L63_A0.093570.817
29_P32_I0.093530.817
119_R133_W0.09330.815
39_V119_R0.09320.814
30_A69_A0.093150.813
28_T72_T0.092850.811
114_E117_A0.092370.807
177_S181_V0.092130.805
101_W106_V0.092080.804
65_S69_A0.091210.797
64_I79_F0.091140.796
95_V99_V0.090870.794
18_V164_A0.090790.793
169_L172_L0.09070.792
148_P172_L0.09060.791
152_A172_L0.09060.791
163_L166_G0.090570.791
93_F108_V0.090370.789
104_V169_L0.090.786
161_A166_G0.090.786
176_V180_V0.089950.786
19_V163_L0.089880.785
35_L66_A0.089830.784
135_W139_F0.089670.783
51_S92_V0.089630.783
42_V149_L0.089350.780
47_V172_L0.08860.774
91_V115_P0.088190.770
14_V87_A0.088090.769
15_L92_V0.088020.769
65_S102_P0.087890.768
152_A157_A0.087880.767
102_P182_R0.087860.767
17_F21_N0.087650.765
15_L68_I0.087440.764
142_R177_S0.087350.763
30_A66_A0.087340.763
55_A59_L0.087330.763
111_F114_E0.087070.760
55_A58_G0.087020.760
138_V158_L0.086950.759
142_R146_Q0.086910.759
18_V30_A0.086770.758
86_N141_L0.086610.756
81_P85_T0.086520.756
47_V50_E0.086150.752
134_V147_L0.086110.752
22_A107_I0.085930.750
48_R98_L0.085910.750
52_V101_W0.085820.749
167_W181_V0.085250.744
51_S166_G0.084810.741
104_V112_R0.084680.740
98_L169_L0.084620.739
169_L183_R0.084360.737
43_V95_V0.084270.736
172_L175_W0.084270.736
141_L145_V0.083990.733
79_F83_I0.083850.732
65_S162_R0.083830.732
65_S146_Q0.083760.731
68_I78_F0.083720.731
95_V110_L0.083720.731
49_R102_P0.083610.730
130_R141_L0.083360.728
64_I68_I0.083280.727
155_V159_G0.083250.727
36_A116_T0.082910.724
88_V95_V0.082790.723
39_V43_V0.082710.722
145_V150_Y0.082530.721
83_I143_L0.082320.719
145_V167_W0.082120.717
84_W88_V0.081960.716
85_T138_V0.081880.715
21_N42_V0.081850.715
12_L48_R0.081810.714
96_S174_L0.081810.714
164_A168_P0.08180.714
69_A164_A0.081690.713
104_V136_A0.081690.713
19_V24_T0.081540.712
46_L53_Q0.081540.712
70_W88_V0.081330.710
21_N132_T0.081140.709
74_S184_A0.081080.708
172_L179_W0.080870.706
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2xq2A0.898467.70.902
3o7qA0.95724.30.946
3h90A0.67383.40.948
4dveA0.598930.949
4a2nB0.52942.70.951
1pw4A0.86632.50.951
4j05A0.94652.50.951
2xutA0.90372.40.952
4f35D0.87172.40.952
1kf6C0.44922.10.953
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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