GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Git3 - G protein-coupled glucose receptor regulating Gpa2
Pfam: PF11710 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 201
Sequences: 27293
Seq/Len: 135.79
HH_delta: 0.115 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
132_I135_P1.798054.165
14_S51_A1.666323.860
42_N135_P1.220492.827
185_I189_A1.132092.622
141_L144_I1.047582.427
135_P138_L1.007712.334
74_C158_C0.91112.111
125_Y129_V0.909972.108
149_P159_W0.904672.096
72_P76_A0.894332.072
25_F41_L0.868022.011
42_N91_W0.859371.991
71_S75_Q0.85541.982
105_R108_W0.82741.917
32_R37_H0.813291.884
100_F104_F0.788781.827
49_I84_G0.759491.759
188_I192_F0.754731.748
123_Y126_W0.75421.747
142_A145_G0.75341.745
151_Y158_C0.751741.741
100_F105_R0.738221.710
189_A192_F0.728461.687
189_A193_Y0.716711.660
57_S61_W0.708881.642
11_S52_L0.697231.615
98_H102_I0.683121.582
46_A87_A0.667561.546
26_F41_L0.666411.544
67_I70_P0.650021.506
75_Q146_L0.636651.475
83_V139_A0.63641.474
43_L47_D0.62851.456
79_F83_V0.622261.441
191_F195_R0.615221.425
22_L41_L0.613861.422
41_L45_L0.604891.401
128_W132_I0.591651.371
89_D179_I0.585211.356
72_P75_Q0.579391.342
182_A186_I0.576911.336
94_A134_V0.568041.316
34_S37_H0.566991.313
46_A88_S0.566391.312
20_A24_L0.555421.287
23_Y27_F0.554371.284
45_L49_I0.535921.241
129_V133_L0.532911.234
57_S73_F0.53221.233
175_W179_I0.527961.223
89_D93_L0.52391.214
39_L95_I0.523061.212
100_F189_A0.520631.206
184_I188_I0.514451.192
86_E175_W0.510921.184
44_L47_D0.510511.183
21_V25_F0.507031.175
70_P73_F0.501381.161
102_I106_P0.49751.152
170_W174_I0.496791.151
183_I187_Y0.492631.141
47_D88_S0.488911.133
141_L145_G0.488751.132
131_W135_P0.488351.131
129_V132_I0.487141.128
93_L182_A0.483871.121
137_L141_L0.478891.109
53_A84_G0.470961.091
104_F193_Y0.470841.091
19_L48_F0.468251.085
192_F196_R0.467131.082
19_L23_Y0.465041.077
100_F186_I0.461971.070
56_I59_I0.461421.069
54_F81_L0.460041.066
93_L186_I0.456951.059
128_W131_W0.452121.047
93_L179_I0.450661.044
99_T102_I0.444361.029
34_S38_Q0.442151.024
168_R171_L0.439551.018
169_L173_Y0.439551.018
187_Y190_I0.439111.017
46_A84_G0.434411.006
130_I134_V0.434171.006
18_S99_T0.431280.999
97_I186_I0.424770.984
38_Q42_N0.423870.982
97_I101_L0.422570.979
149_P152_G0.422020.978
105_R121_Y0.41620.964
132_I136_L0.414680.961
145_G164_Y0.413490.958
91_W131_W0.411150.952
138_L142_A0.410740.951
123_Y127_V0.410370.951
168_R172_H0.408650.947
90_L179_I0.406010.941
16_L19_L0.405370.939
171_L175_W0.404740.938
126_W129_V0.403890.936
81_L85_D0.403870.936
96_A186_I0.403250.934
87_A138_L0.40280.933
82_Q85_D0.402140.932
51_A55_L0.400140.927
25_F33_R0.398110.922
15_L48_F0.394650.914
97_I182_A0.393680.912
142_A146_L0.393520.912
92_I183_I0.392590.909
135_P141_L0.390070.904
87_A91_W0.389960.903
132_I139_A0.389490.902
23_Y26_F0.388450.900
134_V138_L0.387290.897
37_H40_I0.386890.896
58_P62_L0.386850.896
101_L104_F0.3860.894
173_Y176_R0.383150.888
69_A73_F0.3820.885
78_G81_L0.377940.875
17_S44_L0.37390.866
167_Y170_W0.373460.865
124_R127_V0.371130.860
151_Y154_A0.368480.854
176_R179_I0.367990.852
140_S144_I0.364830.845
135_P139_A0.362340.839
139_A143_F0.360090.834
57_S60_R0.360040.834
11_S59_I0.358920.831
77_Q81_L0.358780.831
132_I138_L0.356710.826
96_A190_I0.356030.825
95_I98_H0.3560.825
121_Y124_R0.355450.823
101_L105_R0.354060.820
54_F58_P0.353950.820
122_P127_V0.352430.816
126_W130_I0.351210.814
76_A80_F0.350910.813
15_L51_A0.350080.811
21_V44_L0.349310.809
25_F32_R0.349080.809
79_F139_A0.348750.808
65_G68_I0.348620.808
39_L98_H0.348180.807
191_F194_L0.347860.806
33_R37_H0.34720.804
148_G151_Y0.346610.803
172_H177_F0.344730.799
86_E141_L0.343880.797
18_S21_V0.343590.796
172_H175_W0.343540.796
88_S96_A0.343050.795
192_F195_R0.342940.794
161_P165_E0.341060.790
122_P126_W0.339060.785
61_W64_R0.338580.784
190_I194_L0.338420.784
122_P125_Y0.335410.777
124_R135_P0.335210.777
125_Y128_W0.33520.776
14_S18_S0.333070.772
9_V13_L0.331380.768
11_S51_A0.331330.768
36_R40_I0.331330.768
128_W135_P0.328550.761
39_L82_Q0.325380.754
94_A130_I0.324260.751
53_A57_S0.323040.748
168_R173_Y0.322330.747
48_F52_L0.321970.746
166_W170_W0.321780.745
163_R167_Y0.321460.745
138_L141_L0.321190.744
122_P130_I0.320630.743
136_L139_A0.31990.741
173_Y179_I0.319480.740
22_L44_L0.31910.739
126_W131_W0.317130.735
141_L171_L0.317080.735
162_S166_W0.317060.734
83_V142_A0.316510.733
103_V187_Y0.315980.732
169_L179_I0.315210.730
193_Y196_R0.314570.729
102_I109_K0.314190.728
131_W134_V0.314140.728
60_R68_I0.313630.727
127_V130_I0.312280.723
86_E90_L0.311380.721
124_R132_I0.310450.719
21_V24_L0.308220.714
174_I178_I0.308090.714
36_R95_I0.307150.712
90_L134_V0.306860.711
64_R68_I0.306830.711
40_I98_H0.306520.710
60_R64_R0.306470.710
124_R128_W0.305950.709
147_G150_G0.305090.707
103_V106_P0.30450.705
105_R189_A0.303230.702
148_G152_G0.302620.701
167_Y171_L0.301020.697
146_L149_P0.299160.693
102_I107_N0.296950.688
104_F190_I0.296910.688
42_N45_L0.294680.683
47_D99_T0.293540.680
154_A157_W0.293530.680
180_I184_I0.293130.679
51_A95_I0.291320.675
36_R39_L0.29120.675
8_I59_I0.290470.673
172_H176_R0.288950.669
39_L94_A0.287550.666
160_I164_Y0.286780.664
147_G164_Y0.286750.664
78_G82_Q0.285820.662
70_P75_Q0.28570.662
92_I99_T0.285410.661
50_Q84_G0.284620.659
173_Y177_F0.284440.659
121_Y125_Y0.283640.657
42_N132_I0.28360.657
96_A187_Y0.282270.654
164_Y168_R0.282050.653
8_I12_A0.281780.653
89_D183_I0.281320.652
61_W66_G0.28130.652
183_I186_I0.280890.651
22_L45_L0.280310.649
40_I95_I0.279460.647
30_Y33_R0.279310.647
109_K122_P0.278610.645
42_N131_W0.277430.643
82_Q86_E0.277260.642
53_A80_F0.277090.642
39_L127_V0.277010.642
101_L121_Y0.275580.638
95_I99_T0.275490.638
22_L26_F0.275380.638
144_I147_G0.275380.638
80_F84_G0.27440.636
90_L93_L0.273140.633
35_F39_L0.271560.629
103_V107_N0.271340.629
86_E138_L0.269940.625
152_G156_A0.269710.625
123_Y128_W0.269550.624
150_G153_P0.268210.621
74_C79_F0.2680.621
50_Q85_D0.267150.619
181_F185_I0.266390.617
140_S143_F0.266260.617
22_L25_F0.26540.615
60_R63_A0.264090.612
27_F30_Y0.2640.612
122_P131_W0.263730.611
68_I71_S0.262530.608
98_H122_P0.261840.607
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA0.965299.90.115
2rh1A0.960299.90.115
3vw7A0.965299.90.126
3uonA0.965299.90.134
3sn6R0.965299.90.141
2z73A0.965299.90.146
3rzeA0.960299.90.147
4dklA0.955299.90.15
3pblA0.955299.90.15
3v2yA0.940399.90.153

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