GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
TilS_C - TilS substrate C-terminal domain
Pfam: PF11734 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0383
Length: 74
Sequences: 1182
Seq/Len: 15.97
HH_delta: 0.033 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
21_K29_E0.777672.921
44_C49_I0.581522.184
11_R20_S0.576792.167
59_E62_S0.552142.074
24_K28_Q0.52151.959
44_C47_G0.507891.908
12_I26_L0.506261.902
6_R38_D0.504811.896
42_L49_I0.406871.528
25_K28_Q0.402131.511
3_I43_L0.397511.493
48_E60_R0.397091.492
5_F41_P0.388731.460
25_K29_E0.386381.451
45_D48_E0.384551.445
6_R24_K0.378941.423
1_L50_V0.36361.366
23_L27_F0.360341.354
41_P53_P0.357061.341
27_F40_L0.353491.328
40_L55_L0.349541.313
30_A56_R0.338621.272
27_F52_V0.330091.240
26_L55_L0.325241.222
6_R10_D0.32291.213
4_R10_D0.316291.188
32_I40_L0.311061.168
50_V61_F0.307951.157
1_L45_D0.307671.156
57_V62_S0.290641.092
51_W54_G0.290511.091
45_D50_V0.290451.091
36_Q39_R0.27731.042
4_R44_C0.277221.041
28_Q35_W0.275651.035
13_R20_S0.270241.015
57_V61_F0.267151.004
15_A62_S0.266070.999
34_P37_R0.263290.989
6_R23_L0.248490.933
32_I55_L0.243280.914
7_Q38_D0.237620.893
26_L52_V0.233740.878
18_G59_E0.233640.878
2_T47_G0.229190.861
14_P17_R0.226430.851
22_K28_Q0.22480.844
3_I41_P0.223570.840
30_A55_L0.215840.811
10_D31_K0.213350.801
28_Q31_K0.212410.798
26_L30_A0.21190.796
13_R18_G0.210510.791
19_G55_L0.208960.785
33_P36_Q0.207970.781
39_R46_G0.204740.769
24_K37_R0.198450.745
11_R14_P0.198420.745
12_I58_S0.198350.745
51_W56_R0.1890.710
58_S61_F0.187460.704
8_P23_L0.186940.702
2_T46_G0.186490.701
56_R63_A0.185370.696
5_F39_R0.185010.695
57_V63_A0.183840.691
28_Q34_P0.18340.689
13_R48_E0.181350.681
2_T48_E0.178940.672
15_A57_V0.176470.663
16_G19_G0.176220.662
5_F40_L0.1760.661
15_A63_A0.175770.660
1_L36_Q0.174690.656
33_P37_R0.174270.655
6_R37_R0.172230.647
49_I52_V0.168170.632
6_R9_G0.167940.631
13_R46_G0.167790.630
34_P38_D0.16630.625
10_D44_C0.165480.622
17_R25_K0.164910.619
6_R42_L0.16370.615
11_R30_A0.163340.614
37_R41_P0.161390.606
5_F23_L0.158510.595
22_K25_K0.157180.590
52_V55_L0.156850.589
8_P35_W0.156640.588
1_L12_I0.156250.587
39_R60_R0.15590.586
10_D23_L0.155620.585
51_W58_S0.155440.584
2_T44_C0.155040.582
10_D49_I0.154940.582
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3a2kA199.70.033
1ni5A0.97399.70.056
3hj7A199.70.056
2cxiA0.97397.60.615
3pcoB0.810895.70.711
2rhqB0.810895.60.713
1b7yB0.810895.10.723
3l4gB0.973920.757
3vouA0.52770.888
3tg9A0.71626.60.889

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