GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Git3_C - G protein-coupled glucose receptor regulating Gpa2 C-term
Pfam: PF11970 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0192
Length: 76
Sequences: 8113
Seq/Len: 106.75
HH_delta: -0.056 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
25_W56_Q0.88912.188
40_I43_G0.757251.864
45_S48_L0.748881.843
13_S70_R0.745031.834
47_W51_I0.680021.674
58_S62_V0.673431.657
46_F49_F0.653171.608
20_V66_V0.634631.562
32_H35_Q0.632181.556
33_R36_Y0.605371.490
15_F19_L0.603881.486
47_W50_C0.580071.428
16_I70_R0.574851.415
42_H46_F0.572471.409
48_L52_A0.531621.308
58_S61_F0.522361.286
53_G57_P0.491641.210
10_Q13_S0.49051.207
22_I26_L0.489821.205
50_C53_G0.487831.201
50_C54_F0.47851.178
37_M40_I0.47271.163
42_H45_S0.4721.162
43_G46_F0.458511.128
46_F50_C0.457461.126
44_P47_W0.436121.073
40_I44_P0.428211.054
40_I45_S0.424381.044
11_L14_M0.423351.042
13_S16_I0.42281.041
35_Q40_I0.421911.038
61_F64_C0.420551.035
17_Y67_F0.420151.034
14_M18_P0.41991.033
60_G64_C0.414631.020
11_L17_Y0.407871.004
63_D67_F0.403380.993
45_S49_F0.400030.985
32_H36_Y0.396860.977
10_Q14_M0.396650.976
41_G44_P0.393630.969
14_M21_Y0.390350.961
72_R75_R0.389930.960
56_Q62_V0.388110.955
43_G47_W0.38350.944
25_W63_D0.382890.942
68_T71_E0.382250.941
41_G46_F0.382080.940
49_F53_G0.381250.938
29_F32_H0.376010.925
66_V70_R0.371490.914
42_H50_C0.365230.899
17_Y60_G0.363740.895
57_P61_F0.35960.885
20_V62_V0.359340.884
34_M37_M0.355620.875
15_F26_L0.355380.875
17_Y59_Q0.352280.867
34_M41_G0.345840.851
54_F57_P0.34480.849
41_G45_S0.340350.838
31_A35_Q0.339480.835
48_L51_I0.336640.829
33_R37_M0.336530.828
72_R76_H0.335470.826
64_C67_F0.333760.821
61_F65_L0.331940.817
42_H49_F0.330970.815
8_R12_R0.327740.807
44_P52_A0.325720.802
13_S25_W0.325670.802
16_I66_V0.321690.792
70_R73_P0.319770.787
47_W52_A0.316370.779
14_M57_P0.315110.776
59_Q63_D0.310870.765
43_G48_L0.310050.763
53_G56_Q0.307010.756
34_M40_I0.304690.750
45_S50_C0.304090.748
12_R15_F0.302420.744
18_P64_C0.301360.742
9_R13_S0.298220.734
18_P22_I0.295910.728
42_H48_L0.294970.726
8_R41_G0.292090.719
17_Y66_V0.291120.716
49_F54_F0.287310.707
24_L59_Q0.282220.695
22_I71_E0.281910.694
44_P49_F0.280260.690
43_G49_F0.279740.688
19_L73_P0.277460.683
11_L15_F0.277010.682
37_M43_G0.273420.673
19_L23_V0.271160.667
65_L76_H0.270450.666
8_R13_S0.266230.655
37_M41_G0.265230.653
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
4grvA199.4-0.056
2rh1A0.960599.30.033
3v2yA199.20.06
4iarA199.20.062
3vw7A199.20.078
3emlA199.20.078
4eiyA199.10.097
4ib4A199.10.097
3uonA0.973799.10.098
3oduA199.10.1

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