GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ABC2_membrane_2 - ABC-2 family transporter protein
Pfam: PF12679 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0181
Length: 277
Sequences: 7051
Seq/Len: 25.45
HH_delta: 0.925 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
5_K9_R0.711633.849
4_A122_L0.658723.563
3_I115_G0.625323.382
177_L267_L0.582993.153
4_A118_L0.496582.686
255_L259_A0.486642.632
93_E116_K0.481272.603
7_E116_K0.462332.500
160_L236_L0.442362.392
4_A115_G0.437182.364
266_A270_Y0.410032.218
177_L264_F0.409842.217
177_L271_R0.404452.187
251_W255_L0.384952.082
108_S111_E0.368341.992
113_L268_A0.367921.990
170_V261_T0.343331.857
259_A263_V0.338221.829
177_L268_A0.319511.728
232_P253_S0.31341.695
170_V264_F0.313321.695
7_E10_E0.305851.654
184_S187_S0.302461.636
93_E98_T0.300761.627
115_G119_A0.299511.620
8_F122_L0.295911.600
117_F265_L0.29521.597
86_A175_G0.292751.583
107_I112_I0.292621.583
164_L233_F0.292221.580
12_F15_R0.280851.519
256_I260_Y0.279581.512
258_L262_L0.27951.512
222_P226_F0.27511.488
255_L258_L0.274161.483
181_L271_R0.273961.482
102_L112_I0.269631.458
151_L155_L0.268711.453
8_F12_F0.268531.452
263_V267_L0.268381.451
9_R13_R0.266551.442
51_L54_A0.266151.439
156_L159_L0.258671.399
110_S269_Y0.257561.393
223_N227_L0.256471.387
263_V266_A0.256331.386
173_S268_A0.25571.383
150_D153_S0.255191.380
94_R99_I0.254771.378
254_L258_L0.25371.372
102_L106_P0.253451.371
2_A5_K0.251561.361
256_I259_A0.250461.355
210_I213_S0.24931.348
232_P256_I0.247931.341
113_L269_Y0.247641.339
2_A6_K0.247181.337
9_R12_F0.245771.329
260_Y264_F0.245351.327
128_L132_L0.244991.325
261_T265_L0.243161.315
111_E115_G0.241341.305
270_Y273_Q0.237481.284
258_L261_T0.233151.261
173_S261_T0.232341.257
53_P56_E0.231581.252
170_V260_Y0.230661.247
4_A119_A0.230381.246
224_L227_L0.229681.242
176_L180_S0.227421.230
178_I182_F0.226991.228
99_I272_F0.226181.223
6_K93_E0.223841.211
267_L271_R0.223471.209
156_L240_I0.221041.195
252_P256_I0.219751.188
164_L237_I0.218411.181
117_F173_S0.216431.171
171_F175_G0.2151.163
11_L17_F0.214641.161
166_L261_T0.21411.158
252_P255_L0.213991.157
114_L118_L0.210131.136
271_R274_R0.208141.126
173_S265_L0.207521.122
268_A272_F0.205721.113
50_E53_P0.205111.109
50_E54_A0.204311.105
215_A222_P0.204021.103
204_P207_V0.203781.102
83_I87_S0.203471.100
223_N226_F0.203371.100
120_A172_I0.202911.097
14_S17_F0.202271.094
73_I81_F0.202011.093
6_K10_E0.201841.092
155_L159_L0.198781.075
250_T254_L0.195591.058
11_L123_F0.194961.054
177_L180_S0.19481.054
210_I215_A0.193721.048
7_E119_A0.193371.046
110_S114_L0.193311.045
32_A36_I0.192611.042
270_Y274_R0.192491.041
163_L257_L0.192041.039
35_P38_Q0.191671.037
143_A146_G0.191161.034
170_V257_L0.191081.033
226_F232_P0.189941.027
152_S156_L0.188131.017
173_S264_F0.188131.017
259_A270_Y0.187551.014
10_E100_E0.186781.010
234_N238_G0.186271.007
109_R272_F0.186181.007
90_I113_L0.186111.007
262_L265_L0.185881.005
159_L163_L0.185251.002
53_P145_S0.183530.993
180_S268_A0.183310.991
163_L258_L0.181880.984
29_F77_L0.18170.983
235_L253_S0.180880.978
209_S213_S0.180710.977
269_Y273_Q0.179760.972
8_F119_A0.179340.970
112_I272_F0.176330.954
15_R100_E0.176050.952
152_S155_L0.175770.951
225_S231_S0.175610.950
51_L56_E0.175170.947
228_S231_S0.174970.946
248_L252_P0.174260.942
262_L266_A0.172020.930
233_F237_I0.17060.923
178_I192_S0.170570.922
75_S79_P0.170050.920
265_L268_A0.170020.920
121_I166_L0.169690.918
163_L254_L0.168670.912
73_I77_L0.168650.912
198_L206_I0.167910.908
97_G100_E0.167670.907
209_S214_E0.167140.904
212_N215_A0.166550.901
178_I191_A0.16650.900
83_I172_I0.165620.896
11_L120_A0.165180.893
214_E222_P0.165120.893
11_L15_R0.164890.892
253_S257_L0.164650.890
90_I176_L0.164360.889
88_D92_G0.164140.888
148_P153_S0.163550.885
198_L203_Y0.162750.880
212_N222_P0.162160.877
145_S149_I0.160490.868
94_R180_S0.160430.868
83_I175_G0.159680.864
260_Y263_V0.159320.862
182_F187_S0.158740.859
131_L158_L0.157330.851
109_R112_I0.157060.849
118_L122_L0.156680.847
93_E97_G0.156370.846
33_F206_I0.156240.845
185_S188_A0.156140.844
4_A8_F0.156110.844
101_L105_K0.155910.843
29_F33_F0.15540.840
232_P236_L0.155350.840
193_L197_F0.155010.838
116_K120_A0.154860.838
11_L14_S0.153920.832
259_A262_L0.153470.830
232_P260_Y0.15270.826
248_L251_W0.152220.823
143_A148_P0.152150.823
16_R88_D0.151430.819
264_F267_L0.151260.818
94_R183_R0.150810.816
170_V173_S0.150110.812
95_E185_S0.149790.810
132_L223_N0.148890.805
158_L162_V0.148410.803
80_L230_F0.14830.802
164_L230_F0.148270.802
127_L131_L0.147710.799
16_R20_L0.147230.796
178_I195_L0.147130.796
11_L20_L0.147070.795
177_L181_L0.146940.795
253_S256_I0.14660.793
187_S191_A0.146540.793
236_L240_I0.146180.791
80_L84_I0.145960.789
110_S273_Q0.145360.786
31_L133_V0.145270.786
82_A171_F0.144820.783
6_K100_E0.144690.783
203_Y206_I0.144190.780
252_P259_A0.14390.778
73_I182_F0.143770.778
125_L162_V0.143620.777
164_L171_F0.143460.776
193_L198_L0.143440.776
24_F201_F0.143350.775
93_E115_G0.143220.775
14_S260_Y0.143050.774
87_S188_A0.142280.769
18_W25_L0.14210.769
37_L40_Q0.14210.769
232_P235_L0.142060.768
200_F206_I0.141550.766
232_P239_S0.141470.765
156_L250_T0.141440.765
194_G198_L0.141170.763
201_F206_I0.140820.762
182_F188_A0.140110.758
203_Y228_S0.139530.755
75_S78_G0.137330.743
93_E112_I0.137280.742
79_P82_A0.137060.741
224_L229_P0.136770.740
188_A192_S0.136180.736
236_L254_L0.135770.734
173_S177_L0.135510.733
176_L179_S0.135340.732
92_G185_S0.135110.731
198_L202_L0.134260.726
199_L203_Y0.13420.726
77_L81_F0.134140.725
121_I125_L0.133910.724
235_L239_S0.133880.724
3_I107_I0.133690.723
89_L116_K0.133350.721
120_A176_L0.133280.721
33_F37_L0.132610.717
79_P165_L0.132610.717
114_L269_Y0.132550.717
227_L232_P0.132290.715
73_I200_F0.132160.715
22_I126_L0.132020.714
90_I180_S0.131930.714
187_S190_L0.131920.713
231_S234_N0.131750.713
37_L41_A0.130570.706
10_E181_L0.130380.705
25_L32_A0.130090.704
143_A149_I0.129810.702
190_L193_L0.129370.700
82_A86_A0.129340.700
129_I132_L0.129180.699
203_Y234_N0.12880.697
73_I78_G0.128620.696
193_L201_F0.128570.695
110_S113_L0.128360.694
98_T112_I0.128160.693
119_A175_G0.128130.693
163_L261_T0.127620.690
98_T102_L0.126780.686
114_L265_L0.126770.686
73_I76_F0.126530.684
100_E123_F0.126450.684
34_Y82_A0.126230.683
160_L254_L0.126090.682
251_W258_L0.1260.681
128_L158_L0.125990.681
125_L148_P0.12590.681
10_E182_F0.125510.679
166_L170_V0.125510.679
151_L258_L0.125290.678
178_I181_L0.124860.675
18_W22_I0.124580.674
55_L78_G0.124470.673
35_P188_A0.124450.673
13_R78_G0.124420.673
204_P228_S0.124320.672
222_P225_S0.123880.670
87_S175_G0.123610.669
210_I226_F0.123270.667
175_G192_S0.123140.666
210_I214_E0.122980.665
10_E204_P0.122910.665
10_E102_L0.122660.663
249_S252_P0.122530.663
19_I95_E0.122520.663
99_I112_I0.122310.661
51_L55_L0.122170.661
155_L158_L0.12210.660
121_I172_I0.121970.660
31_L148_P0.121820.659
38_Q41_A0.121650.658
144_I149_I0.121620.658
91_A232_P0.121310.656
87_S91_A0.120950.654
233_F257_L0.120870.654
179_S193_L0.120820.653
24_F29_F0.120730.653
38_Q144_I0.120730.653
91_A121_I0.120630.652
16_R19_I0.120610.652
17_F20_L0.120610.652
160_L240_I0.120390.651
181_L187_S0.120380.651
112_I257_L0.119870.648
235_L249_S0.119690.647
174_L195_L0.11940.646
18_W21_L0.119210.645
115_G118_L0.11920.645
89_L179_S0.118890.643
194_G199_L0.118710.642
230_F234_N0.118690.642
188_A195_L0.118630.642
74_V78_G0.118460.641
197_F239_S0.118170.639
249_S253_S0.117790.637
101_L107_I0.117580.636
112_I116_K0.117460.635
21_L78_G0.117270.634
95_E184_S0.117220.634
132_L251_W0.117080.633
174_L264_F0.116860.632
204_P209_S0.116790.632
256_I264_F0.116750.631
89_L92_G0.116540.630
170_V229_P0.11630.629
27_L225_S0.116240.629
101_L119_A0.11620.628
22_I25_L0.116110.628
96_R176_L0.116080.628
134_G147_I0.11570.626
92_G96_R0.115680.626
153_S240_I0.115610.625
183_R186_A0.11560.625
252_P270_Y0.115390.624
7_E100_E0.115240.623
199_L206_I0.115230.623
144_I154_F0.115020.622
194_G201_F0.1150.622
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4he8J0.368210.90.925
1pi7A0.05426.50.932
2wswA0.57766.40.932
2a65A0.31414.90.936
2ks1B0.14443.60.94
2l2tA0.14082.90.942
4ainA0.5742.80.943
3ixzA0.31052.50.944
1qleD0.155220.946
3hd7B0.14081.90.947
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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