GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ABC2_membrane_3 - ABC-2 family transporter protein
Pfam: PF12698 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0181
Length: 344
Sequences: 4125
Seq/Len: 11.99
HH_delta: 0.733 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
35_A78_I0.758236.157
69_A81_I0.569754.627
65_S68_E0.540374.388
244_L312_G0.497714.042
87_N91_D0.428643.481
91_D97_E0.367432.984
72_A78_I0.360442.927
38_D45_S0.342212.779
325_W329_I0.32982.678
71_D75_N0.328232.665
185_E208_K0.325332.642
36_V49_V0.31682.572
63_Y72_A0.31572.564
329_I333_L0.304992.477
73_L81_I0.29132.365
70_K74_K0.288762.345
35_A63_Y0.288712.344
221_L242_L0.287992.339
250_L335_A0.286692.328
84_I88_F0.280682.279
38_D41_N0.279352.268
82_I103_V0.278882.265
40_D89_S0.266962.168
245_L309_F0.260582.116
45_S89_S0.258152.096
72_A77_K0.250552.035
31_P59_D0.245151.991
66_E70_K0.244841.988
64_D68_E0.243221.975
37_V69_A0.239331.943
87_N90_Q0.239061.941
83_V104_Y0.236121.917
220_S245_L0.234391.903
68_E72_A0.234051.901
200_S203_S0.232831.891
35_A72_A0.224581.824
258_L341_L0.223951.819
213_F246_L0.220641.792
333_L337_V0.220371.789
301_S307_Y0.218491.774
247_L332_L0.218441.774
330_I334_F0.207361.684
254_S335_A0.205891.672
302_S308_W0.201621.637
290_L301_S0.199181.617
52_L120_L0.194081.576
34_V82_I0.192141.560
39_E83_V0.190741.549
239_L243_L0.190611.548
66_E83_V0.189581.539
311_Q327_S0.181061.470
251_A338_Y0.180531.466
80_A116_I0.180491.466
185_E190_T0.179471.457
40_D87_N0.178611.450
248_F309_F0.177961.445
298_Q302_S0.177291.440
183_V269_A0.175851.428
217_L221_L0.175151.422
78_I81_I0.173721.411
194_L204_Y0.173221.407
140_S143_P0.17241.400
255_F276_I0.170821.387
244_L328_L0.170271.383
50_Q53_S0.168431.368
332_L336_V0.167831.363
315_N320_D0.1671.356
39_E66_E0.166151.349
244_L316_I0.163261.326
295_S299_W0.16311.324
19_G228_F0.162111.316
251_A335_A0.16071.305
33_P79_D0.159881.298
269_A273_A0.158131.284
35_A81_I0.157351.278
44_L89_S0.156711.273
248_F252_F0.156011.267
40_D45_S0.154071.251
207_S211_A0.153421.246
44_L92_L0.153371.245
251_A334_F0.15331.245
293_L298_Q0.150911.225
328_L332_L0.15071.224
73_L78_I0.149861.217
202_W206_L0.149151.211
247_L331_L0.148851.209
216_S249_S0.147461.197
33_P59_D0.146411.189
73_L76_G0.146211.187
69_A72_A0.145651.183
20_L227_I0.145431.181
185_E192_E0.144461.173
214_L218_I0.143671.167
185_E194_L0.143521.165
326_I330_I0.143081.162
71_D74_K0.142931.161
296_F299_W0.142341.156
194_L208_K0.142211.155
83_V102_T0.140291.139
284_S294_P0.139871.136
34_V80_A0.139741.135
218_I222_I0.139731.135
10_L14_L0.139361.132
67_E71_D0.137371.115
265_N268_T0.137211.114
68_E71_D0.136541.109
241_L313_L0.136331.107
37_V81_I0.135921.104
294_P297_L0.135841.103
247_L335_A0.13471.094
85_P88_F0.134651.093
330_I333_L0.134281.090
191_R204_Y0.132391.075
187_E266_S0.132111.073
38_D89_S0.131991.072
240_L316_I0.131831.070
251_A331_L0.131161.065
217_L246_L0.130951.063
290_L293_L0.130941.063
190_T198_G0.130921.063
66_E81_I0.130261.058
296_F300_I0.129871.055
128_N131_S0.129721.053
89_S93_L0.129441.051
271_S274_S0.128841.046
179_A269_A0.128621.044
320_D323_E0.12781.038
48_L124_L0.127591.036
301_S304_L0.127481.035
195_L204_Y0.127451.035
263_F268_T0.127091.032
213_F250_L0.126341.026
304_L307_Y0.126161.024
302_S307_Y0.125911.022
337_V341_L0.124911.014
37_V63_Y0.124441.010
84_I101_I0.124111.008
7_I10_L0.123291.001
88_F127_L0.123191.000
203_S207_S0.123121.000
322_S326_I0.122810.997
47_Q50_Q0.122150.992
221_L225_I0.121830.989
127_L131_S0.121210.984
55_S58_F0.121030.983
45_S84_I0.120860.981
333_L336_V0.120860.981
299_W303_F0.120510.979
312_G331_L0.120430.978
172_L252_F0.119810.973
246_L250_L0.119580.971
38_D46_K0.119410.970
288_F292_S0.119180.968
221_L238_F0.119170.968
67_E70_K0.119110.967
332_L335_A0.118670.964
80_A103_V0.118370.961
322_S325_W0.118320.961
295_S298_Q0.118050.959
258_L261_S0.117740.956
316_I324_I0.117580.955
193_R208_K0.117340.953
209_F254_S0.117120.951
294_P298_Q0.11590.941
79_D106_N0.115850.941
312_G315_N0.115710.940
322_S337_V0.115650.939
209_F253_I0.115440.937
91_D99_P0.115230.936
252_F256_G0.114920.933
219_Q223_I0.114860.933
12_I34_V0.114840.933
63_Y81_I0.114580.930
247_L328_L0.114470.930
7_I177_F0.114320.928
178_I256_G0.114170.927
146_V150_P0.113740.924
150_P156_S0.113710.923
76_G106_N0.113220.919
18_I22_F0.11310.918
73_L104_Y0.112530.914
183_V266_S0.112280.912
259_I272_V0.112210.911
174_G181_S0.112040.910
16_L20_L0.111980.909
302_S311_Q0.111910.909
6_F10_L0.110820.900
239_L242_L0.110390.896
185_E189_G0.110330.896
308_W330_I0.110240.895
280_L304_L0.109880.892
334_F338_Y0.109390.888
285_G289_P0.109360.888
174_G252_F0.109110.886
164_P286_G0.108930.885
48_L84_I0.108820.884
38_D84_I0.108610.882
312_G324_I0.108590.882
249_S253_I0.108210.879
158_F161_Y0.107970.877
63_Y78_I0.107940.876
269_A286_G0.107740.875
321_W325_W0.107730.875
47_Q51_M0.107550.873
14_L18_I0.107160.870
210_L214_L0.106950.868
65_S69_A0.10690.868
327_S330_I0.106860.868
263_F272_V0.106510.865
308_W327_S0.106240.863
190_T193_R0.105930.860
77_K239_L0.105040.853
40_D84_I0.104790.851
325_W328_L0.104790.851
106_N113_S0.104540.849
186_K191_R0.104390.848
254_S339_L0.104310.847
289_P293_L0.104070.845
279_L288_F0.104050.845
187_E208_K0.103840.843
281_S284_S0.10370.842
124_L128_N0.103660.842
117_Q120_L0.103570.841
115_I119_A0.103280.839
37_V83_V0.103150.838
122_S322_S0.103150.838
141_N340_L0.103120.837
309_F312_G0.103080.837
80_A105_I0.103060.837
197_S204_Y0.102650.834
41_N64_D0.102220.830
51_M130_S0.102150.829
327_S334_F0.101750.826
17_L20_L0.101730.826
224_I238_F0.101730.826
207_S210_L0.101560.825
45_S88_F0.101550.825
126_Q129_A0.100950.820
267_S271_S0.100820.819
62_E142_S0.100790.818
29_P33_P0.100620.817
16_L24_N0.100610.817
69_A73_L0.100190.814
41_N46_K0.099830.811
183_V186_K0.099810.810
181_S196_S0.099710.810
329_I332_L0.099480.808
283_L297_L0.099230.806
213_F253_I0.099160.805
53_S59_D0.098830.803
41_N45_S0.09870.801
14_L22_F0.098690.801
215_V334_F0.098670.801
161_Y314_R0.098480.800
120_L148_S0.098450.799
250_L254_S0.097960.795
321_W332_L0.097780.794
12_I16_L0.097750.794
260_S269_A0.097740.794
181_S204_Y0.097490.792
280_L306_F0.097360.791
237_N240_L0.097030.788
248_F280_L0.096980.788
267_S286_G0.096980.788
91_D100_N0.096780.786
49_V62_E0.09670.785
243_L328_L0.096680.785
315_N323_E0.09660.784
88_F99_P0.096020.780
243_L247_L0.095850.778
208_K266_S0.09570.777
96_G214_L0.09540.775
45_S48_L0.095380.775
249_S339_L0.095370.774
80_A120_L0.095190.773
188_S192_E0.095110.772
54_N145_P0.094820.770
244_L324_I0.094790.770
39_E86_K0.094750.769
240_L328_L0.09470.769
171_L281_S0.094470.767
234_P237_N0.094170.765
126_Q246_L0.093840.762
223_I310_I0.093410.759
235_F241_L0.093330.758
275_I279_L0.093030.755
15_I23_S0.092910.754
190_T208_K0.092910.754
199_V204_Y0.092760.753
228_F285_G0.092470.751
236_G239_L0.092450.751
274_S278_L0.092050.747
185_E204_Y0.092030.747
209_F250_L0.091780.745
41_N122_S0.091730.745
268_T275_I0.091660.744
185_E207_S0.091520.743
268_T271_S0.091330.742
174_G219_Q0.091210.741
185_E191_R0.091180.740
44_L47_Q0.091110.740
193_R308_W0.091090.740
162_L287_F0.091080.740
110_P158_F0.091010.739
35_A61_V0.090980.739
180_M260_S0.090840.738
248_F260_S0.09060.736
103_V120_L0.090190.732
225_I329_I0.089890.730
53_S62_E0.089860.730
312_G328_L0.089790.729
46_K49_V0.089770.729
105_I113_S0.089770.729
101_I104_Y0.089760.729
71_D77_K0.08950.727
128_N132_E0.089330.725
216_S220_S0.089240.725
184_E188_S0.089040.723
182_I257_F0.088920.722
59_D71_D0.088560.719
126_Q130_S0.088550.719
217_L238_F0.088490.719
326_I329_I0.08840.718
129_A137_I0.088330.717
46_K50_Q0.087880.714
70_K104_Y0.087840.713
277_I290_L0.08780.713
156_S159_A0.087710.712
336_V340_L0.087550.711
19_G285_G0.087530.711
169_F309_F0.087460.710
254_S338_Y0.087230.708
169_F173_I0.087220.708
18_I263_F0.087180.708
321_W338_Y0.087180.708
289_P301_S0.087170.708
278_L288_F0.086870.705
180_M267_S0.086850.705
208_K212_Y0.086730.704
22_F288_F0.086560.703
190_T263_F0.086380.701
59_D141_N0.086370.701
86_K255_F0.086310.701
30_S120_L0.086280.701
7_I81_I0.086060.699
290_L307_Y0.086060.699
6_F22_F0.085970.698
205_W339_L0.085940.698
19_G22_F0.085850.697
62_E67_E0.085740.696
214_L225_I0.085690.696
178_I182_I0.085660.696
106_N109_N0.085610.695
205_W209_F0.085570.695
240_L244_L0.085420.694
46_K86_K0.085350.693
193_R304_L0.085350.693
300_I323_E0.085230.692
68_E86_K0.085190.692
191_R198_G0.085120.691
69_A80_A0.085010.690
286_G310_I0.084980.690
52_L119_A0.084930.690
47_Q126_Q0.084470.686
170_I280_L0.084270.684
43_S89_S0.084250.684
106_N110_P0.084170.683
174_G283_L0.084110.683
16_L227_I0.083860.681
129_A132_E0.083790.680
167_L306_F0.083690.680
270_I278_L0.083640.679
98_S225_I0.083510.678
77_K138_Q0.083340.677
84_I266_S0.083250.676
92_L98_S0.083230.676
120_L254_S0.08320.676
260_S280_L0.083160.675
72_A81_I0.083050.674
165_F169_F0.083050.674
6_F15_I0.083020.674
191_R304_L0.082940.673
171_L248_F0.082930.673
285_G301_S0.082890.673
216_S271_S0.082870.673
121_S125_Q0.082820.673
65_S147_E0.082770.672
190_T195_L0.082760.672
36_V84_I0.082620.671
256_G260_S0.082530.670
307_Y311_Q0.082480.670
70_K81_I0.082390.669
118_N319_G0.082310.668
165_F168_F0.082070.666
281_S287_F0.082050.666
251_A312_G0.081870.665
255_F275_I0.081810.664
321_W328_L0.081810.664
31_P53_S0.081770.664
153_N248_F0.081750.664
34_V49_V0.081530.662
85_P102_T0.08130.660
211_A260_S0.08110.659
117_Q121_S0.081070.658
194_L199_V0.081070.658
131_S137_I0.081050.658
308_W311_Q0.080980.658
41_N336_V0.080970.657
290_L298_Q0.080920.657
123_L127_L0.080910.657
253_I288_F0.080910.657
38_D87_N0.080770.656
169_F271_S0.080640.655
244_L309_F0.080590.654
47_Q127_L0.080490.654
168_F174_G0.080310.652
222_I329_I0.080310.652
76_G275_I0.08020.651
161_Y282_F0.080170.651
91_D98_S0.080160.651
270_I273_A0.080140.651
259_I276_I0.080120.651
199_V241_L0.08010.650
10_L16_L0.080080.650
213_F218_I0.079910.649
188_S219_Q0.079840.648
284_S289_P0.079710.647
63_Y69_A0.07970.647
40_D83_V0.079620.647
213_F271_S0.079570.646
184_E190_T0.07950.646
126_Q200_S0.079470.645
200_S213_F0.079460.645
174_G216_S0.079350.644
39_E44_L0.079230.643
82_I101_I0.079130.643
121_S145_P0.079030.642
291_S295_S0.079020.642
89_S92_L0.078850.640
43_S98_S0.07880.640
67_E142_S0.078620.638
23_S252_F0.078580.638
233_I278_L0.078580.638
178_I201_P0.078380.636
7_I317_I0.07830.636
262_F341_L0.078170.635
166_I169_F0.078160.635
248_F278_L0.078160.635
9_L12_I0.078130.634
238_F242_L0.078080.634
57_N72_A0.078070.634
172_L277_I0.078030.634
183_V204_Y0.078020.634
185_E260_S0.077970.633
278_L287_F0.077860.632
67_E91_D0.07780.632
62_E336_V0.077730.631
73_L215_V0.077730.631
35_A69_A0.077640.630
190_T204_Y0.077620.630
181_S208_K0.077610.630
182_I258_L0.077610.630
15_I19_G0.077580.630
219_Q309_F0.077530.630
167_L271_S0.077480.629
20_L23_S0.077320.628
302_S333_L0.077280.628
14_L21_I0.077160.627
190_T196_S0.077150.626
186_K265_N0.077140.626
299_W302_S0.07710.626
75_N329_I0.077090.626
157_S282_F0.077060.626
186_K260_S0.076980.625
59_D142_S0.076970.625
167_L174_G0.076950.625
300_I303_F0.076930.625
324_I328_L0.076920.625
38_D88_F0.076840.624
173_I188_S0.07680.624
61_V336_V0.076780.623
138_Q333_L0.076690.623
257_F260_S0.076680.623
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3cniA0.433199.30.733
2p0sA0.392497.30.865
3lteA0.357647.80.938
3grcA0.37546.90.938
2zayA0.386642.30.94
3i42A0.34340.90.94
3qaxA0.415740.70.94
3ktoA0.366339.80.941
3cnbA0.383738.80.941
3hdgA0.37535.90.942
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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