GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ABC2_membrane_4 - ABC-2 family transporter protein
Pfam: PF12730 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0181
Length: 232
Sequences: 2300
Seq/Len: 9.91
HH_delta: 0.921 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
73_E96_K0.29842.842
83_L89_R0.276752.636
191_P194_P0.243492.319
4_L99_V0.228812.179
77_G80_K0.223692.130
74_Y79_I0.22142.109
6_K73_E0.215322.051
3_E6_K0.214142.039
3_E96_K0.212962.028
1_K5_K0.207661.978
109_L113_L0.202091.925
82_L86_P0.200481.909
82_L92_I0.197371.880
95_A99_V0.19621.869
105_L144_L0.195141.858
12_L68_L0.184761.760
190_F193_S0.183451.747
5_K8_F0.179961.714
156_I170_S0.179561.710
7_L99_V0.175681.673
5_K9_R0.175271.669
4_L8_F0.17331.650
70_F154_L0.164821.570
93_F154_L0.164691.568
69_L99_V0.164481.566
137_I141_L0.162151.544
97_F152_L0.156481.490
6_K96_K0.156241.488
74_Y161_R0.15041.432
28_L118_I0.146861.399
67_A166_A0.144781.379
2_A6_K0.144031.372
157_S165_V0.143311.365
113_L117_L0.142241.355
149_F152_L0.140261.336
138_S141_L0.139851.332
117_L121_L0.139561.329
40_D43_G0.139071.324
73_E92_I0.132961.266
73_E78_T0.13261.263
163_S166_A0.132261.260
69_L100_I0.131371.251
156_I169_I0.129381.232
156_I160_F0.127031.210
93_F158_S0.126971.209
63_I170_S0.125471.195
3_E95_A0.124971.190
19_I33_Y0.123731.178
4_L102_I0.123171.173
13_F17_L0.121061.153
94_L98_I0.121011.152
71_S157_S0.120341.146
176_L180_L0.119721.140
70_F158_S0.119511.138
164_I168_I0.119061.134
79_I92_I0.118531.129
25_L122_F0.11851.129
95_A98_I0.1181.124
173_L177_G0.116761.112
67_A71_S0.115011.095
162_N165_V0.11481.093
88_S91_K0.114411.090
73_E89_R0.114351.089
2_A85_R0.113721.083
23_F118_I0.113071.077
165_V169_I0.112831.075
189_L194_P0.112231.069
66_A81_L0.111351.060
170_S173_L0.111271.060
117_L120_L0.110781.055
39_I60_I0.110461.052
6_K80_K0.109761.045
97_F106_L0.109021.038
97_F154_L0.108991.038
6_K64_I0.108941.038
70_F93_F0.106921.018
12_L180_L0.10671.016
155_F158_S0.10671.016
190_F194_P0.106561.015
28_L123_G0.106461.014
95_A109_L0.105621.006
62_I104_I0.105551.005
63_I167_I0.105521.005
7_L11_K0.105431.004
83_L92_I0.105091.001
11_K80_K0.104730.997
2_A20_F0.104710.997
14_W162_N0.104710.997
19_I153_L0.103960.990
16_L61_L0.103760.988
101_L148_L0.102770.979
188_F191_P0.102760.979
71_S168_I0.102720.978
4_L169_I0.102110.972
173_L192_F0.101930.971
116_L141_L0.101350.965
27_S30_L0.100770.960
148_L168_I0.100760.960
56_L162_N0.10010.953
120_L127_F0.100080.953
163_S167_I0.099960.952
60_I150_I0.099890.951
22_L153_L0.099590.948
69_L114_I0.099160.944
58_L147_S0.099070.944
72_R76_N0.098780.941
9_R18_I0.098480.938
80_K164_I0.098330.936
72_R86_P0.098090.934
6_K167_I0.097990.933
78_T177_G0.097640.930
141_L145_L0.097250.926
30_L109_L0.097160.925
10_S72_R0.096610.920
108_F143_F0.096580.920
88_S102_I0.096010.914
16_L19_I0.0960.914
100_I151_S0.095610.911
100_I159_L0.095420.909
11_K14_W0.095270.907
6_K79_I0.095110.906
168_I171_I0.094970.904
65_L100_I0.094340.898
71_S74_Y0.094140.897
81_L85_R0.093890.894
25_L32_N0.093810.893
153_L194_P0.09380.893
140_L144_L0.0930.886
78_T82_L0.092950.885
19_I22_L0.092810.884
65_L83_L0.092740.883
39_I43_G0.092710.883
105_L129_Y0.092640.882
180_L183_I0.092580.882
10_S78_T0.092410.880
40_D149_F0.092310.879
55_S178_I0.092310.879
74_Y78_T0.092180.878
74_Y103_I0.092120.877
107_L138_S0.091550.872
175_L184_S0.091550.872
10_S13_F0.091440.871
35_G141_L0.09090.866
165_V168_I0.090790.865
71_S163_S0.09070.864
93_F161_R0.090620.863
78_T89_R0.090320.860
103_I193_S0.08990.856
64_I157_S0.089770.855
36_N121_L0.089750.855
105_L188_F0.088770.845
152_L155_F0.08830.841
72_R79_I0.088270.841
71_S145_L0.088240.840
37_P41_P0.088210.840
50_F53_Y0.087910.837
44_W119_G0.087840.837
62_I151_S0.087710.835
145_L151_S0.087550.834
68_L71_S0.087510.833
62_I66_A0.087240.831
70_F163_S0.087230.831
155_F160_F0.087220.831
121_L156_I0.087110.830
114_I137_I0.087040.829
2_A80_K0.086770.826
117_L128_D0.086690.826
59_P64_I0.086560.824
31_F158_S0.08640.823
28_L175_L0.086290.822
148_L156_I0.086290.822
62_I105_L0.086130.820
33_Y47_F0.086110.820
120_L136_L0.086080.820
24_L53_Y0.086050.820
171_I175_L0.085970.819
160_F169_I0.08590.818
109_L120_L0.085850.818
59_P147_S0.085670.816
189_L192_F0.085620.815
71_S78_T0.085570.815
88_S103_I0.085490.814
63_I169_I0.085370.813
91_K157_S0.085330.813
10_S164_I0.085030.810
108_F152_L0.085030.810
104_I149_F0.084960.809
7_L13_F0.08490.809
74_Y89_R0.084550.805
19_I23_F0.084460.804
34_F38_N0.084460.804
86_P119_G0.084430.804
40_D127_F0.084410.804
24_L189_L0.084170.802
59_P191_P0.084080.801
68_L81_L0.084030.800
73_E80_K0.083730.797
64_I75_K0.083570.796
66_A100_I0.083440.795
89_R92_I0.083320.794
3_E71_S0.08330.793
77_G81_L0.08310.791
117_L185_S0.082960.790
116_L138_S0.082940.790
61_L65_L0.082690.788
75_K175_L0.082490.786
97_F101_L0.082490.786
6_K10_S0.082380.785
68_L72_R0.082360.784
153_L188_F0.082130.782
22_L185_S0.081830.779
79_I85_R0.081760.779
10_S82_L0.081750.779
21_L114_I0.081710.778
85_R92_I0.08170.778
64_I165_V0.081550.777
17_L65_L0.081410.775
28_L178_I0.081380.775
102_I106_L0.081350.775
42_N45_F0.081310.774
60_I192_F0.081240.774
112_F140_L0.081230.774
21_L121_L0.081140.773
18_I90_K0.080980.771
58_L175_L0.080980.771
112_F144_L0.080820.770
146_L149_F0.080750.769
23_F53_Y0.080670.768
128_D185_S0.080590.768
17_L59_P0.080410.766
89_R157_S0.080380.766
53_Y56_L0.080330.765
123_G184_S0.080320.765
7_L12_L0.080150.763
34_F142_L0.080150.763
63_I191_P0.079960.762
130_S157_S0.079950.761
73_E82_L0.079910.761
70_F126_G0.079710.759
97_F139_Y0.07970.759
13_F83_L0.079380.756
116_L159_L0.079370.756
111_S160_F0.079360.756
151_S173_L0.079360.756
24_L62_I0.079350.756
18_I146_L0.079340.756
50_F71_S0.079240.755
7_L100_I0.079190.754
90_K104_I0.079030.753
33_Y37_P0.079020.753
64_I184_S0.078910.752
108_F168_I0.078830.751
65_L97_F0.07880.750
48_S117_L0.078710.750
101_L108_F0.078650.749
40_D56_L0.078640.749
10_S76_N0.078580.748
100_I161_R0.078510.748
79_I152_L0.078480.747
6_K78_T0.078420.747
176_L179_I0.078350.746
4_L22_L0.078240.745
100_I170_S0.077910.742
7_L66_A0.077760.741
69_L98_I0.077690.740
27_S176_L0.077650.740
26_L30_L0.077490.738
37_P141_L0.077460.738
59_P174_F0.077420.737
102_I117_L0.077420.737
14_W107_L0.077050.734
62_I89_R0.076910.732
57_F61_L0.076870.732
19_I49_S0.076860.732
23_F51_S0.07670.730
62_I150_I0.07670.730
150_I183_I0.076660.730
116_L144_L0.076610.730
99_V181_S0.07660.730
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2a65A0.353414.80.921
1qleD0.18537.60.93
4he8J0.38366.60.932
4humA0.85784.70.937
3hd7A0.14663.50.94
2qjyA0.38362.80.943
1wjxA0.17672.40.944
3kl4B0.13362.50.944
2zxeA0.34052.20.946
3ixzA0.340520.947
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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