GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF3814 - Domain of unknown function (DUF3814)
Pfam: PF12769 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 87
Sequences: 520
Seq/Len: 5.98
HH_delta: 0.93 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
61_F65_F0.454542.863
68_T72_V0.414482.610
54_T58_V0.371442.339
12_F16_E0.288771.819
7_F10_A0.240711.516
16_E42_V0.240611.515
37_S67_A0.239981.511
78_T82_L0.236251.488
80_R84_M0.224631.415
58_V62_I0.21411.348
3_M40_I0.213991.348
19_W23_P0.210361.325
27_T39_I0.208411.313
55_L58_V0.204091.285
24_A32_V0.203381.281
50_S66_L0.201871.271
19_W32_V0.197241.242
22_P32_V0.195851.233
17_V40_I0.191121.204
38_G71_V0.186271.173
52_P57_Q0.186071.172
23_P37_S0.183071.153
45_M64_V0.182751.151
21_V29_L0.182441.149
51_A61_F0.182151.147
13_V17_V0.182031.146
4_L76_L0.181631.144
7_F41_I0.17971.132
19_W22_P0.179271.129
24_A33_T0.171451.080
38_G65_F0.171371.079
51_A54_T0.171221.078
60_G66_L0.170331.073
47_A60_G0.169611.068
32_V77_V0.168951.064
46_I50_S0.168751.063
48_A64_V0.168371.060
39_I69_I0.166621.049
2_T42_V0.166531.049
23_P75_F0.16461.037
42_V67_A0.164321.035
16_E33_T0.164251.034
46_I62_I0.163031.027
79_D83_D0.162531.024
18_I22_P0.160251.009
66_L77_V0.159671.006
48_A59_L0.159031.002
33_T75_F0.156770.987
2_T65_F0.156520.986
51_A83_D0.155160.977
37_S40_I0.153470.967
20_K24_A0.153180.965
50_S57_Q0.153160.965
35_A75_F0.15180.956
51_A57_Q0.151540.954
10_A57_Q0.14980.943
65_F68_T0.149710.943
30_M34_N0.148610.936
33_T47_A0.14810.933
83_D86_K0.147860.931
6_V12_F0.146530.923
8_V12_F0.145790.918
5_T85_F0.145710.918
31_S78_T0.144880.912
55_L68_T0.143260.902
31_S82_L0.141640.892
42_V72_V0.141610.892
54_T57_Q0.141590.892
78_T84_M0.141360.890
48_A57_Q0.140710.886
45_M83_D0.140230.883
12_F38_G0.139890.881
20_K31_S0.139740.880
55_L59_L0.139610.879
26_H29_L0.139190.877
5_T83_D0.138140.870
3_M6_V0.1380.869
23_P60_G0.136750.861
60_G64_V0.136720.861
18_I79_D0.136390.859
52_P83_D0.136170.858
4_L7_F0.13480.849
26_H34_N0.134480.847
54_T62_I0.133480.841
11_C72_V0.13330.840
21_V26_H0.132340.833
2_T13_V0.131870.831
15_Y19_W0.131680.829
13_V75_F0.131670.829
3_M17_V0.1310.825
54_T59_L0.130650.823
2_T52_P0.130040.819
12_F76_L0.12980.817
56_A60_G0.129250.814
19_W79_D0.127730.804
59_L62_I0.1270.800
20_K85_F0.126530.797
60_G67_A0.125630.791
59_L69_I0.124150.782
22_P72_V0.123990.781
18_I39_I0.123590.778
11_C42_V0.123510.778
39_I85_F0.122650.772
2_T39_I0.121730.767
15_Y45_M0.12170.766
16_E72_V0.121610.766
41_I55_L0.121190.763
3_M13_V0.121070.762
16_E32_V0.120720.760
12_F23_P0.120450.759
16_E20_K0.120440.759
56_A63_A0.120320.758
36_I79_D0.119780.754
16_E61_F0.119540.753
50_S56_A0.11950.753
27_T31_S0.119370.752
4_L8_V0.119120.750
41_I67_A0.119110.750
63_A67_A0.118860.749
35_A69_I0.118770.748
37_S69_I0.118490.746
47_A86_K0.118260.745
2_T76_L0.118250.745
50_S59_L0.118170.744
28_P34_N0.11790.743
44_A50_S0.117770.742
34_N70_N0.117680.741
41_I44_A0.117280.739
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4hw9A0.97711.80.93
2vv5A0.9775.70.939
2qjyA0.73564.50.942
2v50A0.96554.20.942
3aqpA0.942540.943
1vf5A0.73563.60.944
3w9iA0.96553.60.944
1pp9C0.73562.80.947
4h44A0.73562.70.947
3cx5C0.73562.70.947
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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