GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
CHAT - CHAT domain
Pfam: PF12770 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0093
Length: 287
Sequences: 1904
Seq/Len: 6.63
HH_delta: 0.845 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
147_H246_Y0.479724.140
260_R264_R0.380463.283
241_F259_L0.367963.176
199_E232_P0.331982.865
151_H198_C0.322692.785
194_V242_M0.315472.723
131_K181_E0.305962.640
41_E263_R0.292722.526
241_F262_A0.277052.391
152_G197_A0.273332.359
41_E59_Y0.272152.349
257_E260_R0.265832.294
53_E267_R0.262562.266
131_K135_L0.256652.215
83_V109_A0.244972.114
29_I40_W0.238892.062
108_E235_D0.233692.017
244_R247_R0.232772.009
108_E196_S0.230181.987
108_E149_A0.228681.974
9_D13_P0.228641.973
244_R265_A0.227431.963
149_A235_D0.224251.935
191_R224_P0.216751.871
144_D191_R0.210971.821
234_P237_A0.209391.807
179_A217_A0.204211.762
244_R248_A0.198171.710
201_A228_G0.195911.691
102_L108_E0.194511.679
52_A264_R0.193721.672
106_Q110_D0.191251.651
16_E54_R0.190351.643
163_G176_L0.187071.614
108_E147_H0.185971.605
131_K174_D0.185661.602
26_R58_S0.18241.574
227_I245_F0.181441.566
130_T133_A0.180931.561
146_L150_G0.178921.544
261_Q264_R0.17691.527
233_V282_F0.175751.517
237_A278_D0.174121.503
152_G198_C0.17311.494
248_A261_Q0.171521.480
49_R54_R0.169031.459
50_F53_E0.168661.456
30_V60_A0.167851.449
229_M238_A0.16761.446
193_V218_F0.167521.446
248_A253_Q0.166781.439
5_R44_P0.166461.437
182_L218_F0.164291.418
158_P161_Q0.164121.416
31_P40_W0.161841.397
197_A200_S0.160111.382
193_V223_A0.159751.379
126_G129_A0.159371.375
12_F51_L0.154771.336
194_V246_Y0.153321.323
241_F263_R0.153011.321
225_A255_V0.150981.303
145_I192_L0.150021.295
153_T163_G0.149761.292
6_A10_A0.145551.256
248_A265_A0.143591.239
86_N89_F0.143051.235
8_Y16_E0.142361.229
159_P162_S0.142141.227
102_L235_D0.141891.225
61_P219_L0.140671.214
258_A262_A0.139471.204
227_I284_L0.139121.201
240_R269_D0.13911.200
166_L177_L0.138561.196
253_Q257_E0.137881.190
155_D161_Q0.13761.188
28_I60_A0.136611.179
151_H197_A0.133961.156
104_G235_D0.133691.154
108_E112_L0.133631.153
253_Q261_Q0.133091.149
146_L190_P0.133041.148
5_R9_D0.13191.138
225_A284_L0.13161.136
154_F213_G0.130751.128
215_A285_Y0.130431.126
49_R53_E0.129871.121
53_E268_R0.129011.113
151_H213_G0.128271.107
233_V238_A0.128151.106
149_A196_S0.127471.100
183_A220_Q0.126281.090
131_K175_G0.126271.090
26_R56_A0.125951.087
264_R267_R0.125891.086
59_Y283_V0.12511.080
198_C201_A0.125041.079
238_A242_M0.123871.069
196_S235_D0.12341.065
11_L35_L0.12141.048
61_P66_L0.121391.048
60_A66_L0.1211.044
246_Y249_L0.119111.028
128_E133_A0.118561.023
177_L182_L0.11841.022
196_S242_M0.118141.020
198_C235_D0.117451.014
254_S257_E0.117041.010
192_L245_F0.116911.009
155_D162_S0.116861.009
276_P280_A0.11671.007
14_P19_L0.116681.007
105_A109_A0.116681.007
255_V284_L0.116181.003
5_R47_D0.115150.994
111_A243_R0.114120.985
134_L138_L0.113960.983
226_V278_D0.113940.983
199_E202_S0.113840.982
162_S166_L0.113770.982
105_A181_E0.11270.973
133_A137_A0.112670.972
35_L187_L0.112170.968
30_V62_S0.112090.967
196_S238_A0.111270.960
86_N106_Q0.110670.955
147_H245_F0.110640.955
259_L262_A0.110450.953
12_F16_E0.110280.952
245_F249_L0.109780.947
215_A228_G0.109740.947
191_R255_V0.109340.944
27_L259_L0.109220.943
136_E141_R0.109160.942
116_L246_Y0.108280.934
264_R268_R0.108250.934
164_L197_A0.107880.931
200_S229_M0.107660.929
262_A266_L0.107410.927
134_L148_F0.106860.922
161_Q180_E0.10640.918
245_F255_V0.106240.917
235_D242_M0.106180.916
257_E261_Q0.105640.912
148_F164_L0.105520.911
229_M282_F0.105510.911
165_V176_L0.105440.910
277_Y282_F0.105260.908
129_A166_L0.105110.907
150_G197_A0.104540.902
210_E216_R0.10440.901
83_V116_L0.104190.899
87_P167_S0.104140.899
38_L41_E0.10370.895
124_L133_A0.103560.894
147_H196_S0.103540.894
107_R110_D0.102870.888
238_A282_F0.102840.888
27_L55_Y0.10280.887
198_C213_G0.102460.884
178_S181_E0.101910.880
89_F150_G0.101590.877
162_S212_L0.101450.876
132_D136_E0.101130.873
255_V263_R0.101030.872
151_H201_A0.100540.868
242_M282_F0.100380.866
249_L258_A0.100050.863
194_V245_F0.099680.860
239_A243_R0.099680.860
87_P106_Q0.099650.860
13_P17_E0.099550.859
78_R144_D0.099370.858
201_A213_G0.098530.850
26_R256_A0.098170.847
133_A136_E0.097930.845
62_S66_L0.097150.838
106_Q126_G0.097130.838
134_L166_L0.097120.838
196_S200_S0.096650.834
110_D114_E0.096470.833
126_G167_S0.096120.830
8_Y267_R0.096050.829
150_G211_V0.095940.828
5_R46_P0.095630.825
85_G109_A0.095590.825
44_P50_F0.095050.820
72_R76_P0.094750.818
147_H235_D0.094630.817
15_L19_L0.094390.815
109_A161_Q0.09430.814
52_A241_F0.094270.814
101_P122_R0.093940.811
160_D183_A0.093810.810
152_G212_L0.093470.807
88_D101_P0.09340.806
108_E242_M0.093350.806
83_V87_P0.093220.805
257_E265_A0.092880.802
266_L270_S0.092880.802
146_L254_S0.092570.799
213_G216_R0.092180.796
151_H200_S0.092070.795
32_D36_H0.091960.794
106_Q109_A0.091780.792
241_F266_L0.091680.791
152_G164_L0.09160.791
267_R270_S0.091520.790
240_R243_R0.091450.789
164_L195_L0.091370.789
52_A267_R0.09120.787
240_R244_R0.091060.786
187_L276_P0.090620.782
245_F259_L0.090590.782
83_V86_N0.090110.778
241_F252_G0.089990.777
84_I124_L0.089790.775
5_R11_L0.089350.771
178_S182_L0.089250.770
108_E246_Y0.089240.770
281_G285_Y0.089210.770
56_A256_A0.089080.769
233_V281_G0.088550.764
195_L229_M0.088350.762
26_R30_V0.088140.761
8_Y12_F0.088130.761
27_L257_E0.088080.760
143_P146_L0.087930.759
56_A257_E0.087880.758
210_E219_L0.087830.758
27_L51_L0.087810.758
6_A43_L0.087750.757
148_F235_D0.087660.757
197_A213_G0.087630.756
105_A108_E0.087510.755
177_L218_F0.087490.755
84_I134_L0.087080.752
115_L243_R0.087040.751
144_D188_R0.087020.751
256_A259_L0.086990.751
115_L252_G0.08680.749
45_D54_R0.086410.746
39_P42_A0.086390.746
185_L221_A0.086370.745
198_C233_V0.086320.745
124_L129_A0.086120.743
82_L143_P0.085990.742
243_R247_R0.085990.742
28_I284_L0.085440.737
29_I59_Y0.085280.736
109_A112_L0.08520.735
42_A283_V0.085010.734
152_G201_A0.084970.733
211_V216_R0.084970.733
130_T174_D0.084950.733
50_F57_I0.084830.732
88_D127_P0.084740.731
112_L147_H0.084690.731
106_Q125_V0.084630.730
115_L247_R0.084540.730
56_A260_R0.084420.729
107_R252_G0.084240.727
245_F284_L0.084190.727
42_A280_A0.084180.726
155_D159_P0.084150.726
35_L148_F0.084010.725
111_A114_E0.083750.723
110_D261_Q0.083380.720
122_R137_A0.083320.719
7_L138_L0.083240.718
87_P126_G0.083150.718
77_P118_A0.083090.717
83_V138_L0.08290.715
203_G210_E0.082680.714
84_I148_F0.08260.713
110_D123_V0.082390.711
150_G213_G0.082250.710
57_I83_V0.082210.709
58_S61_P0.082180.709
29_I223_A0.082150.709
241_F281_G0.082040.708
109_A123_V0.081860.706
247_R252_G0.081770.706
187_L190_P0.081510.703
102_L105_A0.081440.703
203_G216_R0.081010.699
29_I57_I0.080870.698
102_L196_S0.080850.698
6_A15_L0.080660.696
8_Y13_P0.080430.694
233_V277_Y0.080380.694
237_A266_L0.080030.691
22_Q25_R0.079710.688
112_L243_R0.079680.688
35_L221_A0.079640.687
197_A229_M0.079640.687
24_K55_Y0.079420.685
190_P201_A0.079390.685
238_A241_F0.079390.685
167_S236_Q0.07920.684
32_D210_E0.079070.682
73_P76_P0.0790.682
9_D250_L0.078980.682
135_L181_E0.07850.677
166_L213_G0.07850.677
27_L54_R0.078480.677
129_A133_A0.078410.677
213_G267_R0.078380.676
41_E57_I0.078270.675
4_G41_E0.07820.675
69_L72_R0.077910.672
219_L224_P0.077870.672
182_L195_L0.077730.671
82_L85_G0.07770.671
90_G242_M0.077550.669
102_L149_A0.077380.668
67_L71_S0.077310.667
242_M246_Y0.07730.667
200_S263_R0.077260.667
188_R193_V0.077210.666
164_L253_Q0.077040.665
152_G213_G0.076980.664
71_S75_S0.076960.664
153_T199_E0.07670.662
158_P180_E0.076570.661
192_L225_A0.076510.660
28_I57_I0.07620.658
11_L31_P0.076150.657
118_A123_V0.076070.657
14_P260_R0.075920.655
39_P231_W0.075890.655
19_L22_Q0.075760.654
50_F225_A0.075670.653
103_P107_R0.075650.653
111_A115_L0.075620.653
183_A186_D0.075610.653
87_P105_A0.075580.652
57_I74_P0.075520.652
36_H210_E0.075310.650
74_P251_Q0.075170.649
82_L266_L0.074990.647
49_R182_L0.074960.647
7_L253_Q0.074930.647
126_G218_F0.074870.646
74_P164_L0.074670.644
54_R160_D0.07450.643
70_R187_L0.07440.642
180_E226_V0.074240.641
107_R240_R0.074140.640
182_L185_L0.074140.640
12_F53_E0.074130.640
150_G190_P0.07410.639
167_S175_G0.073950.638
219_L278_D0.073850.637
138_L146_L0.073780.637
5_R19_L0.073710.636
31_P59_Y0.073680.636
5_R13_P0.073520.634
150_G164_L0.073420.634
263_R282_F0.073210.632
8_Y15_L0.073130.631
42_A238_A0.072970.630
154_F163_G0.072970.630
162_S210_E0.072950.630
227_I268_R0.072910.629
221_A231_W0.072880.629
27_L57_I0.072660.627
9_D122_R0.072650.627
208_G211_V0.072640.627
229_M281_G0.072610.627
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3uoaB0.693498.10.845
4af8A0.881597.80.86
1cvrA0.867697.70.862
3bijA0.682997.20.878
2j32A0.717896.80.886
3h11B0.742296.80.886
3od5A0.735296.70.888
4jj7A0.745696.70.888
3sirA0.721396.70.889
3e4cA0.836296.30.894
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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