GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF3815 - Protein of unknown function (DUF3815)
Pfam: PF12821 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0470
Length: 130
Sequences: 1749
Seq/Len: 13.45
HH_delta: 0.898 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
10_A31_G0.418362.785
94_G110_G0.41632.771
7_F32_A0.354732.361
37_V58_V0.339792.262
34_G59_V0.319662.128
7_F28_G0.319222.125
60_G127_G0.304412.026
57_F127_G0.280981.870
82_I120_I0.28051.867
94_G113_A0.268561.788
30_I62_L0.264141.758
20_P23_A0.260481.734
11_I28_G0.259991.731
9_A13_F0.252451.680
3_F36_L0.248071.651
109_N112_E0.233151.552
6_A35_W0.219661.462
52_T116_I0.218791.456
17_F83_I0.212581.415
25_P29_L0.210711.403
19_A27_A0.203791.357
98_L106_A0.20031.333
41_L46_L0.200121.332
91_A113_A0.198591.322
14_A19_A0.197491.315
59_V84_P0.196691.309
42_S51_A0.194511.295
41_L54_V0.193151.286
97_S109_N0.192581.282
103_Y106_A0.189311.260
123_G127_G0.187571.249
74_A79_V0.186721.243
110_G125_V0.183721.223
34_G84_P0.183251.220
3_F32_A0.180741.203
35_W38_Y0.178411.188
4_L8_I0.176971.178
83_I95_M0.176621.176
102_N105_S0.176541.175
56_A123_G0.16881.124
65_L69_R0.168221.120
90_L113_A0.166041.105
13_F16_L0.165191.100
57_F61_L0.164491.095
43_A114_L0.163241.087
63_A78_I0.161841.077
7_F25_P0.160561.069
17_F85_L0.159731.063
93_R109_N0.15851.055
45_G50_V0.157061.045
30_I66_F0.156681.043
37_V55_A0.15631.040
59_V81_G0.155641.036
19_A23_A0.155381.034
110_G113_A0.155241.033
89_S93_R0.153481.022
67_A71_K0.153071.019
76_V80_P0.152121.013
34_G81_G0.152031.012
46_L54_V0.150140.999
24_L111_F0.148820.991
67_A77_F0.147550.982
50_V108_S0.145120.966
122_V125_V0.14450.962
12_G38_Y0.144240.960
49_F119_A0.143670.956
64_E128_T0.14360.956
99_V121_A0.140280.934
11_I24_L0.140030.932
114_L118_L0.139910.931
89_S120_I0.139310.927
10_A38_Y0.139160.926
26_W66_F0.139110.926
22_R44_F0.138820.924
98_L101_G0.138470.922
15_I24_L0.137880.918
101_G106_A0.137360.914
110_G126_L0.136530.909
18_N80_P0.135250.900
37_V54_V0.134850.898
63_A77_F0.134710.897
37_V41_L0.134680.897
25_P28_G0.134260.894
91_A124_L0.134010.892
57_F123_G0.133280.887
26_W29_L0.133150.886
60_G124_L0.132710.883
24_L103_Y0.132690.883
30_I122_V0.132350.881
83_I96_Y0.131590.876
17_F86_V0.131320.874
22_R61_L0.131060.872
79_V83_I0.130940.872
100_S108_S0.130130.866
99_V120_I0.130080.866
110_G114_L0.129250.860
53_F122_V0.129140.860
105_S108_S0.128960.858
64_E125_V0.12870.857
97_S106_A0.128070.853
73_P92_Y0.12790.851
15_I47_G0.127880.851
29_L54_V0.127520.849
55_A61_L0.126830.844
14_A24_L0.126130.840
55_A86_V0.125990.839
15_I20_P0.12590.838
93_R96_Y0.12580.837
43_A50_V0.125540.836
97_S105_S0.125440.835
120_I123_G0.125190.833
64_E68_R0.12480.831
113_A124_L0.124510.829
17_F115_L0.124340.828
26_W70_L0.124330.828
19_A82_I0.123920.825
67_A70_L0.123330.821
4_L29_L0.123030.819
99_V110_G0.122710.817
93_R97_S0.122470.815
22_R68_R0.122370.815
7_F11_I0.122190.813
30_I81_G0.121990.812
61_L69_R0.120790.804
81_G86_V0.120730.804
23_A72_A0.120150.800
96_Y105_S0.120070.799
33_L62_L0.119690.797
103_Y114_L0.118930.792
25_P65_L0.118810.791
52_T119_A0.118580.789
70_L77_F0.118160.787
44_F108_S0.117870.785
38_Y117_A0.117640.783
14_A35_W0.117590.783
26_W115_L0.117140.780
14_A80_P0.116930.778
125_V128_T0.116690.777
115_L127_G0.116320.774
58_V62_L0.115580.769
64_E127_G0.115330.768
30_I85_L0.115250.767
106_A110_G0.115180.767
21_R65_L0.114940.765
39_L43_A0.114820.764
91_A117_A0.114810.764
29_L43_A0.114790.764
7_F31_G0.114780.764
89_S100_S0.114670.763
37_V72_A0.114640.763
107_L110_G0.114170.760
21_R62_L0.114040.759
9_A14_A0.1140.759
9_A83_I0.113890.758
36_L43_A0.113760.757
37_V44_F0.113560.756
33_L37_V0.113540.756
46_L103_Y0.113290.754
13_F95_M0.113250.754
9_A60_G0.113140.753
111_F126_L0.112850.751
17_F31_G0.11280.751
97_S101_G0.112220.747
18_N53_F0.111320.741
86_V113_A0.11130.741
13_F18_N0.111260.741
45_G121_A0.110710.737
6_A81_G0.11070.737
90_L124_L0.110240.734
118_L124_L0.110190.733
78_I112_E0.110110.733
21_R108_S0.109790.731
91_A94_G0.109660.730
113_A125_V0.108780.724
55_A127_G0.108730.724
56_A111_F0.10870.724
108_S112_E0.108580.723
74_A118_L0.108470.722
21_R24_L0.108320.721
27_A96_Y0.108090.720
46_L102_N0.107540.716
107_L111_F0.107380.715
89_S97_S0.107370.715
5_A56_A0.107190.714
71_K80_P0.106950.712
92_Y109_N0.106890.712
88_G92_Y0.106860.711
67_A74_A0.106840.711
75_T92_Y0.106490.709
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1zcdA0.576916.10.898
1ciiA0.376915.20.899
1otsA110.10.907
4eneA17.70.911
3orgA0.99235.10.918
2i88A0.39234.80.919
3nd0A0.86154.40.92
3hd6A0.992330.926
2b2hA0.84622.20.931
2k3cA0.253820.932
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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