GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF3817 - Domain of unknown function (DUF3817)
Pfam: PF12823 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 92
Sequences: 516
Seq/Len: 5.61
HH_delta: 0.935 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
42_P46_F0.450793.022
5_R57_D0.372852.500
16_S47_L0.327532.196
25_M28_K0.304422.041
26_P30_L0.300322.013
59_A69_T0.296991.991
24_A37_V0.267281.792
10_A82_T0.264651.774
28_K37_V0.249211.671
25_M29_Y0.248691.667
37_V41_G0.236621.586
11_I15_I0.230831.548
13_E16_S0.225821.514
46_F49_M0.225711.513
72_A85_F0.224871.508
55_A72_A0.223591.499
38_K42_P0.220241.477
66_L70_L0.202311.356
10_A86_E0.192281.289
57_D61_K0.191351.283
25_M40_I0.188621.265
71_L89_L0.187841.259
4_R7_R0.186791.252
58_L62_Y0.183831.232
36_A39_I0.179811.206
27_L31_A0.179751.205
72_A89_L0.178881.199
35_E39_I0.177961.193
26_P31_A0.174721.171
13_E21_L0.173711.165
6_F10_A0.168731.131
14_G83_F0.167831.125
69_T73_L0.16651.116
30_L91_R0.166381.115
56_L60_S0.163711.098
17_L78_I0.16241.089
28_K41_G0.159011.066
52_L56_L0.157431.055
21_L37_V0.156591.050
23_I27_L0.156141.047
87_R91_R0.153511.029
49_M53_V0.153021.026
53_V57_D0.152471.022
39_I42_P0.148590.996
15_I83_F0.148390.995
17_L76_S0.1480.992
24_A28_K0.147930.992
9_I54_A0.146430.982
53_V91_R0.142870.958
6_F86_E0.142720.957
20_L37_V0.142390.955
10_A75_A0.142040.952
6_F51_Y0.141770.950
17_L82_T0.140730.944
12_L47_L0.140540.942
14_G75_A0.139480.935
59_A78_I0.138860.931
67_K70_L0.138740.930
18_L23_I0.137990.925
3_L68_R0.137790.924
55_A73_L0.137290.920
18_L83_F0.137210.920
5_R50_L0.135330.907
34_P37_V0.134660.903
80_F84_W0.132290.887
9_I50_L0.131870.884
26_P34_P0.131440.881
24_A36_A0.130430.874
18_L80_F0.13010.872
88_W91_R0.129780.870
26_P29_Y0.129490.868
18_L24_A0.129460.868
55_A69_T0.126250.846
60_S63_R0.12550.841
70_L77_V0.125090.839
81_G86_E0.124970.838
48_F76_S0.123770.830
19_L40_I0.122520.821
76_S81_G0.120040.805
19_L36_A0.119580.802
5_R58_L0.119210.799
51_Y89_L0.11890.797
39_I43_I0.118790.796
14_G63_R0.118720.796
17_L21_L0.118040.791
71_L85_F0.117660.789
20_L24_A0.116010.778
59_A75_A0.11560.775
84_W87_R0.115110.772
52_L61_K0.113430.760
52_L77_V0.113420.760
24_A41_G0.113410.760
78_I82_T0.113310.760
2_A57_D0.112890.757
23_I26_P0.11220.752
6_F16_S0.111410.747
19_L91_R0.110770.743
33_N36_A0.110380.740
21_L26_P0.110120.738
20_L34_P0.109710.736
27_L34_P0.10950.734
8_V90_R0.109240.732
20_L25_M0.107640.722
16_S41_G0.107470.721
17_L77_V0.107430.720
10_A59_A0.10720.719
51_Y75_A0.106930.717
2_A65_S0.106590.715
38_K41_G0.106570.714
31_A34_P0.10640.713
35_E38_K0.105780.709
4_R53_V0.105760.709
8_V87_R0.105290.706
42_P49_M0.10520.705
67_K87_R0.104610.701
10_A17_L0.104270.699
4_R84_W0.103940.697
27_L42_P0.103690.695
65_S68_R0.103370.693
13_E48_F0.103250.692
24_A34_P0.103160.692
51_Y79_P0.103010.691
51_Y59_A0.102770.689
51_Y86_E0.102770.689
61_K65_S0.102480.687
11_I46_F0.102190.685
43_I46_F0.10190.683
63_R66_L0.101720.682
19_L46_F0.101710.682
52_L74_L0.101290.679
78_I83_F0.101050.677
52_L75_A0.100820.676
58_L86_E0.099350.666
85_F89_L0.098940.663
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4f35D0.3372.50.935
4he8L0.92392.40.936
3j0fE0.31522.10.938
4he8M0.92391.70.94
2qtsA0.48911.70.94
2ei4A0.64131.70.941
4humA0.78261.60.941
4ev6A0.70651.60.942
3rkoM0.95651.60.942
3h0lA0.751.50.942
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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