GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
2TM - 2TM domain
Pfam: PF13239 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 83
Sequences: 398
Seq/Len: 4.8
HH_delta: 0.897 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
18_H57_H0.430612.902
76_K79_K0.411012.770
40_Y45_W0.342.291
46_P49_G0.298532.012
74_E78_Q0.274611.851
26_N47_I0.237391.600
25_V29_L0.227681.534
13_K73_E0.22571.521
22_Y26_N0.218281.471
34_L38_P0.212561.432
49_G53_G0.210291.417
15_F58_A0.209921.415
30_I47_I0.199811.347
5_A8_R0.199791.346
22_Y51_G0.19821.336
31_F35_F0.193521.304
50_W53_G0.188751.272
15_F19_L0.188011.267
16_Y73_E0.183211.235
14_G57_H0.179781.212
25_V50_W0.178141.201
78_Q82_E0.176831.192
29_L50_W0.176751.191
73_E76_K0.175831.185
9_V73_E0.174431.176
46_P51_G0.173411.169
18_H21_V0.173271.168
33_N43_P0.171121.153
38_P45_W0.166711.123
19_L54_L0.165451.115
27_S31_F0.164971.112
17_R24_I0.164261.107
26_N51_G0.161841.091
22_Y46_P0.16011.079
15_F62_F0.160011.078
17_R21_V0.158631.069
24_I59_L0.155821.050
48_L51_G0.151591.022
32_I43_P0.150421.014
77_I81_M0.148050.998
8_R30_I0.146950.990
29_L42_W0.145640.981
48_L52_I0.145220.979
24_I56_I0.143220.965
11_R61_V0.142240.959
33_N36_T0.141420.953
12_R73_E0.138580.934
10_K80_L0.135370.912
13_K16_Y0.134980.910
4_R82_E0.134660.907
71_D75_R0.134420.906
25_V51_G0.134330.905
12_R16_Y0.134110.904
70_K82_E0.131540.886
5_A16_Y0.130150.877
76_K80_L0.128580.867
9_V14_G0.12770.861
20_A55_A0.126340.851
9_V34_L0.125960.849
72_W76_K0.125850.848
11_R43_P0.12580.848
41_F44_L0.125670.847
12_R80_L0.125590.846
12_R15_F0.124280.838
72_W80_L0.123020.829
11_R60_K0.122460.825
38_P41_F0.121650.820
7_K82_E0.121240.817
32_I44_L0.120360.811
26_N49_G0.119950.808
35_F39_G0.118720.800
12_R76_K0.11860.799
29_L43_P0.118410.798
8_R62_F0.117980.795
18_H50_W0.117940.795
20_A32_I0.117550.792
27_S30_I0.117420.791
29_L46_P0.116980.788
42_W49_G0.116540.785
11_R27_S0.115490.778
28_F32_I0.115340.777
25_V53_G0.11510.776
23_L78_Q0.115040.775
5_A73_E0.11410.769
23_L27_S0.113980.768
12_R72_W0.113630.766
21_V50_W0.113630.766
32_I53_G0.112270.757
5_A9_V0.111670.753
48_L56_I0.10980.740
8_R71_D0.109460.738
9_V72_W0.108710.733
52_I56_I0.108130.729
19_L48_L0.107590.725
7_K10_K0.107460.724
41_F71_D0.107060.721
33_N42_W0.106890.720
25_V54_L0.106870.720
3_E54_L0.106860.720
18_H60_K0.106760.719
19_L27_S0.106530.718
33_N38_P0.106140.715
13_K72_W0.105210.709
20_A28_F0.104950.707
9_V76_K0.104870.707
12_R61_V0.103890.700
74_E82_E0.103880.700
74_E79_K0.103870.700
68_F80_L0.103730.699
30_I34_L0.103330.696
30_I59_L0.103280.696
17_R79_K0.10290.693
10_K82_E0.102680.692
68_F72_W0.102340.690
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2a65A0.903616.20.897
3tx3A0.915770.912
3giaA0.92776.40.913
3b60A0.95185.80.914
3b5xA0.95185.70.915
3qf4B0.95185.60.915
3ecqA0.62655.60.915
4a82A0.95185.40.916
4hfiA0.43373.80.921
2yl4A0.95183.70.921
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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