GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
WYL - WYL domain
Pfam: PF13280 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 172
Sequences: 2906
Seq/Len: 16.9
HH_delta: 0.909 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
6_L16_I1.000764.179
18_F32_V0.729923.048
153_E161_R0.716872.994
101_R153_E0.710622.968
32_V46_L0.706342.950
168_L171_M0.675812.822
33_D51_R0.65862.750
15_Q33_D0.65482.734
99_R130_I0.614792.567
99_R156_E0.605842.530
18_F64_I0.551592.303
17_R68_E0.514532.149
97_E134_P0.503352.102
130_I155_L0.50072.091
103_D151_H0.487472.036
154_V164_L0.485012.025
158_E162_Q0.481722.012
15_Q51_R0.462441.931
19_D29_E0.456831.908
17_R29_E0.453741.895
17_R31_R0.453451.894
101_R155_L0.452641.890
15_Q31_R0.452371.889
19_D66_S0.449471.877
150_D167_R0.44091.841
100_L152_V0.439471.835
99_R132_T0.42791.787
8_Q12_E0.419011.750
101_R128_S0.41221.721
32_V48_A0.412121.721
30_R50_D0.408661.707
101_R130_I0.40491.691
48_A59_F0.396951.658
18_F59_F0.391511.635
97_E132_T0.388931.624
30_R59_F0.382571.598
17_R70_L0.37971.586
21_R65_R0.371631.552
138_S159_S0.368171.538
14_R69_I0.3631.516
99_R155_L0.36131.509
146_L167_R0.361071.508
162_Q166_E0.355141.483
50_D57_R0.352951.474
124_D128_S0.333211.392
142_L163_R0.326291.363
37_L61_L0.325271.358
142_L167_R0.318231.329
97_E156_E0.314121.312
150_D170_K0.314061.312
43_R60_R0.312341.304
145_L164_L0.311831.302
166_E170_K0.311611.301
124_D130_I0.311271.300
15_Q72_E0.305311.275
145_L152_V0.297141.241
50_D53_R0.294981.232
33_D74_F0.290411.213
50_D59_F0.288591.205
138_S163_R0.286141.195
161_R165_K0.28531.191
165_K169_E0.283031.182
5_T69_I0.279331.166
100_L131_V0.277091.157
35_Y56_F0.274271.145
14_R71_D0.27221.137
13_K74_F0.271561.134
18_F67_I0.26661.113
105_K151_H0.266591.113
8_Q69_I0.266481.113
101_R124_D0.266181.112
35_Y74_F0.265961.111
35_Y48_A0.263281.099
96_I159_S0.258321.079
102_L152_V0.256251.070
18_F48_A0.254581.063
16_I67_I0.252651.055
31_R70_L0.24391.019
142_L160_L0.242761.014
125_D128_S0.240481.004
31_R51_R0.238440.996
102_L148_F0.23810.994
98_V135_V0.237680.993
36_R47_I0.237320.991
80_D83_D0.236660.988
34_P46_L0.233440.975
45_Y60_R0.233240.974
49_Y54_E0.233010.973
64_I67_I0.230470.962
6_L64_I0.228730.955
142_L164_L0.228110.953
36_R81_L0.227290.949
102_L110_L0.226940.948
122_E130_I0.226710.947
5_T67_I0.22520.940
13_K76_P0.220850.922
14_R73_P0.215960.902
9_A34_P0.215760.901
47_I84_Y0.21460.896
6_L61_L0.2140.894
135_V141_L0.213980.894
53_R59_F0.213410.891
5_T8_Q0.212790.889
100_L145_L0.210360.878
43_R62_D0.209340.874
146_L164_L0.208170.869
19_D65_R0.207840.868
22_S26_E0.206850.864
3_L7_L0.206530.862
138_S142_L0.205870.860
163_R166_E0.20480.855
79_F84_Y0.203610.850
158_E161_R0.202670.846
2_V67_I0.198850.830
15_Q70_L0.195120.815
106_A151_H0.194250.811
31_R52_E0.194150.811
19_D27_G0.194090.811
166_E169_E0.19280.805
149_G152_V0.19250.804
20_Y59_F0.189330.791
30_R57_R0.189060.790
163_R167_R0.188030.785
98_V133_F0.186750.780
49_Y53_R0.185350.774
22_S28_K0.183460.766
140_E144_W0.181850.759
39_Y44_W0.180760.755
96_I137_D0.180610.754
20_Y64_I0.180390.753
102_L106_A0.179670.750
109_Y113_R0.179590.750
107_A111_K0.179550.750
103_D106_A0.178570.746
157_P161_R0.177810.743
137_D159_S0.176240.736
148_F152_V0.17520.732
83_D87_K0.174470.729
95_P134_P0.174390.728
31_R72_E0.173420.724
21_R25_S0.171190.715
142_L154_V0.170150.711
162_Q169_E0.169840.709
21_R27_G0.169460.708
91_S140_E0.168920.705
102_L109_Y0.167860.701
20_Y30_R0.16740.699
143_R147_S0.1670.697
7_L37_L0.166330.695
167_R170_K0.165660.692
98_V160_L0.163730.684
2_V5_T0.163520.683
45_Y63_R0.163310.682
20_Y63_R0.16290.680
35_Y78_D0.162740.680
154_V157_P0.161680.675
165_K168_L0.161630.675
144_W147_S0.161250.673
124_D127_G0.161040.673
9_A16_I0.160950.672
164_L167_R0.160710.671
110_L144_W0.159150.665
115_F131_V0.158180.661
53_R57_R0.158040.660
156_E159_S0.157510.658
56_F84_Y0.157470.658
104_P108_R0.157030.656
47_I58_T0.156380.653
14_R70_L0.156330.653
131_V160_L0.156080.652
6_L67_I0.155130.648
12_E69_I0.155010.647
38_Y42_G0.154140.644
20_Y45_Y0.153630.642
27_G65_R0.153460.641
36_R79_F0.153420.641
70_L74_F0.15250.637
38_Y85_L0.152370.636
138_S160_L0.152260.636
20_Y48_A0.151780.634
16_I32_V0.151690.633
63_R112_E0.150670.629
38_Y47_I0.150550.629
23_A63_R0.150190.627
146_L168_L0.150050.627
10_I13_K0.150020.626
58_T84_Y0.149920.626
98_V138_S0.1490.622
30_R53_R0.14870.621
9_A69_I0.148430.620
3_L44_W0.148370.620
10_I34_P0.14780.617
18_F65_R0.147710.617
22_S25_S0.147460.616
98_V154_V0.146950.614
38_Y58_T0.146690.613
7_L11_R0.14650.612
104_P127_G0.145870.609
159_S165_K0.145090.606
36_R42_G0.144940.605
28_K59_F0.144910.605
48_A57_R0.144110.602
85_L89_F0.143830.601
154_V161_R0.142960.597
89_F92_Y0.141770.592
121_E130_I0.139770.584
37_L44_W0.139470.582
28_K52_E0.139310.582
154_V160_L0.138550.579
62_D141_L0.138210.577
106_A109_Y0.137770.575
43_R81_L0.137230.573
109_Y148_F0.136420.570
96_I99_R0.135870.567
102_L129_I0.13550.566
143_R146_L0.134720.563
146_L171_M0.134270.561
40_Y85_L0.133730.558
40_Y144_W0.133680.558
122_E132_T0.133550.558
157_P160_L0.133410.557
74_F79_F0.133330.557
38_Y43_R0.13310.556
165_K171_M0.132990.555
10_I46_L0.132740.554
25_S28_K0.132450.553
18_F50_D0.131950.551
60_R63_R0.131880.551
144_W148_F0.131770.550
107_A124_D0.131150.548
6_L46_L0.128420.536
139_E167_R0.128420.536
103_D128_S0.128410.536
18_F66_S0.128230.535
73_P169_E0.127940.534
138_S141_L0.12790.534
89_F136_N0.127750.533
10_I37_L0.127720.533
81_L85_L0.12760.533
163_R170_K0.126890.530
142_L146_L0.126240.527
110_L114_P0.125510.524
62_D144_W0.125470.524
161_R164_L0.125460.524
90_G140_E0.125430.524
146_L149_G0.125020.522
143_R167_R0.124990.522
44_W133_F0.124810.521
102_L131_V0.124510.520
116_H140_E0.124380.519
39_Y43_R0.12420.519
121_E129_I0.124170.519
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1sg5A0.430235.40.909
2ctfA0.52338.50.93
3gr1A0.42446.10.935
4g1iA0.42446.10.935
3imoA0.47675.90.935
3gr0A0.42445.80.935
1xw3A0.42445.70.936
1wi3A0.3144.70.938
3iarA0.49424.60.938
3kq0A0.8144.40.939
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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