GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Toprim_Crpt - C-terminal repeat of topoisomerase
Pfam: PF13342 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0167
Length: 62
Sequences: 824
Seq/Len: 13.29
HH_delta: 0.811 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
14_K20_E0.499442.403
34_K45_D0.495742.385
51_D57_K0.442712.130
32_L47_Y0.441742.125
37_K43_P0.400641.928
14_K33_I0.352221.695
7_I21_V0.333331.604
5_F25_L0.328351.580
19_E23_E0.304251.464
29_K49_V0.302541.456
23_E31_G0.297391.431
23_E27_K0.296081.425
33_I36_F0.29491.419
10_T15_K0.292851.409
20_E31_G0.290241.396
14_K36_F0.268141.290
15_K22_K0.265041.275
49_V59_E0.256461.234
22_K26_E0.254911.227
38_S42_K0.254121.223
12_A44_F0.253531.220
51_D55_K0.246431.186
29_K47_Y0.231421.113
2_G8_W0.229011.102
10_T13_G0.226741.091
12_A36_F0.220211.060
44_F48_L0.217081.044
30_T47_Y0.212341.022
38_S44_F0.212251.021
56_V59_E0.21171.019
19_E22_K0.209741.009
11_I44_F0.207150.997
2_G22_K0.205690.990
37_K40_K0.204870.986
37_K41_G0.203870.981
9_K15_K0.201780.971
5_F50_L0.196230.944
6_R9_K0.193130.929
27_K34_K0.192860.928
36_F44_F0.192180.925
35_G58_F0.190830.918
8_W12_A0.187370.902
16_L20_E0.185490.892
33_I39_K0.184720.889
11_I58_F0.183920.885
51_D54_K0.183420.883
35_G38_S0.182910.880
11_I56_V0.176970.851
12_A23_E0.172570.830
20_E23_E0.170980.823
16_L21_V0.170070.818
24_L30_T0.167710.807
28_G57_K0.165980.799
20_E33_I0.165740.797
11_I48_L0.165690.797
15_K21_V0.164080.789
8_W56_V0.162190.780
13_G19_E0.160020.770
42_K60_F0.158940.765
30_T48_L0.15890.765
22_K25_L0.158710.764
12_A58_F0.158250.761
35_G45_D0.154660.744
17_T20_E0.154520.743
18_D26_E0.1540.741
19_E54_K0.153910.741
16_L23_E0.153750.740
7_I56_V0.151250.728
49_V52_D0.151110.727
23_E29_K0.149150.718
38_S60_F0.148090.713
4_G15_K0.146180.703
41_G53_D0.146150.703
37_K42_K0.14280.687
44_F58_F0.141790.682
20_E29_K0.141550.681
17_T30_T0.141190.679
38_S45_D0.137810.663
39_K42_K0.137510.662
6_R20_E0.137510.662
46_A60_F0.137420.661
15_K59_E0.136610.657
15_K49_V0.136520.657
12_A48_L0.135240.651
52_D57_K0.1350.650
2_G47_Y0.134840.649
38_S43_P0.134750.648
7_I50_L0.132810.639
9_K58_F0.13270.638
50_L57_K0.131470.633
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2gaiA0.5323140.811
1s94A0.451610.60.82
1a62A0.93557.70.831
3u5wA0.85487.40.832
2hhzA0.75817.10.833
1jb3A0.91945.90.839
3fkhA0.83875.20.843
3llpA0.887150.844
2q9kA0.87150.844
2qzbA0.96774.60.846
If you are interested in a protein containing this domain,
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