GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF4117 - Domain of unknown function (DUF4117)
Pfam: PF13491 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 171
Sequences: 1240
Seq/Len: 7.25
HH_delta: 0.925 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
25_S46_L0.401813.680
18_F47_M0.290262.658
16_A70_P0.273932.509
48_G51_G0.269272.466
16_A74_I0.248922.280
138_L146_I0.23472.149
105_G147_L0.225392.064
9_G77_G0.224822.059
95_G154_G0.20751.900
95_G102_S0.206861.894
3_R6_E0.206351.890
102_S154_G0.19811.814
22_A47_M0.194941.785
14_L149_V0.174341.597
19_L54_L0.171831.574
45_N52_A0.168891.547
139_G142_G0.168311.541
45_N55_A0.167951.538
99_L151_L0.163951.501
60_Q125_I0.161971.483
66_A70_P0.160841.473
145_I148_L0.157081.439
16_A77_G0.15621.431
134_L143_A0.155021.420
52_A55_A0.151971.392
131_A135_V0.14911.365
95_G98_L0.14851.360
25_S45_N0.147811.354
50_L138_L0.1471.346
106_L144_L0.145921.336
134_L147_L0.143831.317
108_S131_A0.138441.268
148_L152_L0.138391.267
141_V145_I0.136661.252
9_G12_L0.13481.235
98_L154_G0.134321.230
7_I153_I0.133211.220
56_D94_L0.132021.209
142_G159_F0.131921.208
154_G157_L0.129981.190
152_L164_V0.129061.182
59_F67_Y0.127791.170
96_L100_L0.127641.169
71_L140_K0.125621.150
68_L107_L0.125461.149
58_L66_A0.125121.146
10_I149_V0.124181.137
64_L107_L0.123141.128
9_G65_G0.120731.106
156_L163_W0.120461.103
56_D60_Q0.119891.098
13_L18_F0.119731.097
133_L136_K0.11861.086
5_R17_L0.118041.081
105_G109_L0.117931.080
65_G107_L0.116651.068
98_L150_L0.116591.068
72_L158_L0.11481.051
74_I83_R0.113341.038
45_N51_G0.113291.038
13_L77_G0.112841.033
108_S123_G0.111961.025
21_L75_V0.111911.025
131_A143_A0.111321.019
55_A59_F0.110981.016
15_L77_G0.110541.012
52_A56_D0.109941.007
8_L15_L0.109531.003
61_L88_R0.109461.002
13_L22_A0.108620.995
10_I79_R0.108360.992
20_L67_Y0.107770.987
151_L155_L0.107690.986
125_I157_L0.107190.982
61_L125_I0.106710.977
159_F162_S0.106620.976
65_G103_L0.105160.963
83_R87_R0.104830.960
140_K144_L0.104690.959
153_I157_L0.104620.958
58_L166_L0.104410.956
69_L97_L0.104340.956
43_V47_M0.10430.955
95_G99_L0.104140.954
90_I94_L0.103060.944
62_F100_L0.102250.936
69_L105_G0.10210.935
126_I129_L0.101570.930
7_I20_L0.101310.928
6_E10_I0.101180.927
133_L137_L0.10090.924
54_L58_L0.100640.922
97_L101_L0.100470.920
69_L73_L0.099820.914
19_L59_F0.099650.913
55_A66_A0.099530.912
102_S105_G0.099290.909
20_L77_G0.098820.905
11_A149_V0.098650.903
13_L17_L0.098560.903
47_M130_L0.098060.898
67_Y70_P0.097990.897
68_L99_L0.097680.895
150_L157_L0.097620.894
132_S136_K0.097510.893
23_L58_L0.097470.893
144_L148_L0.097290.891
107_L110_L0.097180.890
144_L151_L0.096980.888
105_G143_A0.096540.884
7_I16_A0.095970.879
134_L138_L0.095640.876
5_R16_A0.095370.873
103_L152_L0.095310.873
68_L140_K0.094830.868
94_L130_L0.09470.867
6_E9_G0.094660.867
6_E162_S0.093670.858
101_L139_G0.093280.854
5_R70_P0.093130.853
72_L96_L0.092630.848
4_K8_L0.092590.848
149_V154_G0.092570.848
17_L50_L0.092420.846
22_A114_F0.092040.843
110_L144_L0.091270.836
78_I106_L0.090950.833
49_I141_V0.090580.830
84_R90_I0.090350.827
71_L131_A0.090280.827
110_L156_L0.090220.826
83_R86_L0.090020.824
95_G160_G0.089760.822
78_I82_R0.089580.820
82_R126_I0.089560.820
7_I11_A0.089550.820
122_G128_Y0.089530.820
5_R134_L0.088870.814
92_R160_G0.088840.814
20_L24_I0.088570.811
68_L111_I0.088410.810
47_M55_A0.088370.809
15_L104_S0.088150.807
111_I151_L0.087940.805
67_Y125_I0.087550.802
100_L108_S0.087530.802
85_S106_L0.087510.801
15_L113_S0.087450.801
117_G122_G0.08740.800
9_G156_L0.087060.797
21_L57_F0.087060.797
93_W146_I0.087030.797
11_A17_L0.086910.796
64_L123_G0.086870.796
117_G120_Y0.086440.792
71_L137_L0.086330.791
135_V139_G0.086220.790
84_R97_L0.085940.787
155_L160_G0.085640.784
77_G120_Y0.08550.783
10_I80_L0.085170.780
10_I165_D0.08490.778
65_G104_S0.084790.777
142_G162_S0.084710.776
5_R89_R0.084550.774
72_L100_L0.084290.772
9_G13_L0.083940.769
6_E21_L0.083740.767
61_L89_R0.083630.766
78_I89_R0.083590.766
59_F118_L0.083160.762
71_L155_L0.08310.761
70_P156_L0.083050.761
68_L71_L0.082990.760
7_I134_L0.082940.760
75_V114_F0.082330.754
148_L158_L0.08230.754
76_W93_W0.082270.753
62_F66_A0.082230.753
59_F96_L0.082080.752
42_E87_R0.082050.751
23_L45_N0.082010.751
134_L166_L0.081850.750
41_A104_S0.081840.750
53_Y109_L0.081770.749
60_Q159_F0.081720.748
53_Y138_L0.081570.747
77_G128_Y0.081340.745
157_L163_W0.081160.743
78_I153_I0.0810.742
96_L99_L0.080650.739
66_A69_L0.080430.737
158_L161_F0.080280.735
100_L104_S0.080250.735
94_L97_L0.080120.734
45_N48_G0.080070.733
92_R96_L0.080060.733
4_K7_I0.079830.731
59_F66_A0.079780.731
146_I152_L0.079740.730
92_R142_G0.07950.728
47_M75_V0.079410.727
64_L152_L0.079320.726
5_R8_L0.07930.726
12_L80_L0.07930.726
156_L164_V0.079090.724
24_I165_D0.079070.724
138_L143_A0.079020.724
45_N121_G0.078930.723
25_S97_L0.078770.721
105_G131_A0.078580.720
49_I145_I0.078570.720
83_R138_L0.078310.717
84_R108_S0.078310.717
8_L11_A0.078190.716
3_R135_V0.07810.715
102_S147_L0.07810.715
51_G55_A0.078010.714
108_S112_P0.078010.714
15_L97_L0.077950.714
68_L74_I0.077860.713
8_L13_L0.077680.711
60_Q121_G0.077530.710
42_E130_L0.077340.708
81_F93_W0.077290.708
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2iubA0.380110.60.925
4ev6A0.380110.40.925
4i0uA0.380190.927
2wscL0.47377.30.93
4h44A0.53226.40.931
1jb0L0.403540.937
3ne5A0.40943.70.939
3w9iA0.46783.50.939
2k1eA0.49122.70.942
4he8L0.91812.30.945
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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