GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Acetyltransf_7 - Acetyltransferase (GNAT) domain
Pfam: PF13508 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0257
Length: 79
Sequences: 48947
Seq/Len: 619.58
HH_delta: 0.034 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
45_S75_L3.240612.470
52_L77_F3.238822.468
18_I51_L2.974792.267
16_G34_V2.409691.836
38_Y41_K2.30881.759
65_N68_A2.215571.688
45_S74_K2.201961.678
15_V38_Y2.201611.678
7_V14_I2.140411.631
69_I73_E2.13111.624
50_Y53_E2.090341.593
20_L51_L2.03841.553
50_Y54_K2.029471.547
49_N75_L1.989261.516
9_E14_I1.950941.487
70_K73_E1.924731.467
10_D38_Y1.921221.464
48_L75_L1.912231.457
6_F50_Y1.810721.380
18_I47_L1.809041.379
35_D38_Y1.78981.364
10_D15_V1.780381.357
45_S49_N1.766291.346
68_A72_Y1.731091.319
8_A43_I1.704271.299
46_K50_Y1.641531.251
71_F75_L1.5731.199
48_L77_F1.564241.192
13_E38_Y1.555531.185
44_G71_F1.541291.175
66_P69_I1.505871.148
17_F33_A1.49681.141
6_F54_K1.475261.124
43_I46_K1.463251.115
48_L72_Y1.439821.097
20_L55_A1.428661.089
27_A55_A1.383481.054
8_A47_L1.380441.052
65_N69_I1.372541.046
19_R31_Y1.330341.014
42_G45_S1.317151.004
19_R30_G1.30830.997
52_L75_L1.304560.994
54_K58_K1.301110.992
64_T68_A1.270560.968
13_E37_E1.263710.963
21_W30_G1.242550.947
62_L72_Y1.239750.945
34_V39_R1.237190.943
46_K49_N1.193570.910
32_L48_L1.184320.903
36_P39_R1.18430.902
10_D41_K1.171780.893
13_E35_D1.158880.883
39_R67_A1.145330.873
66_P70_K1.144790.872
29_I48_L1.143250.871
56_K59_K1.141490.870
28_Y31_Y1.137270.867
70_K74_K1.135350.865
20_L54_K1.106290.843
34_V43_I1.063650.811
26_F61_F1.05980.808
10_D13_E1.044370.796
32_L72_Y1.037220.790
34_V44_G1.037160.790
49_N53_E1.035820.789
72_Y77_F1.025540.782
9_E12_G1.023260.780
49_N52_L1.01920.777
26_F30_G1.018130.776
8_A16_G0.994910.758
17_F31_Y0.99470.758
38_Y43_I0.960110.732
21_W24_E0.957060.729
20_L27_A0.955720.728
28_Y61_F0.944160.719
31_Y63_F0.94030.717
64_T69_I0.929180.708
68_A71_F0.922130.703
45_S71_F0.914630.697
40_G67_A0.901310.687
54_K57_S0.900480.686
67_A70_K0.889140.678
47_L50_Y0.884330.674
8_A46_K0.878250.669
28_Y63_F0.870440.663
30_G63_F0.865070.659
48_L71_F0.84740.646
23_N26_F0.840720.641
15_V43_I0.833190.635
65_N70_K0.827360.630
62_L77_F0.824250.628
18_I32_L0.822910.627
19_R33_A0.822470.627
6_F9_E0.818930.624
32_L44_G0.818510.624
34_V47_L0.815140.621
15_V35_D0.797170.607
52_L56_K0.791140.603
31_Y65_N0.783680.597
22_P25_D0.780980.595
48_L52_L0.772830.589
69_I72_Y0.77170.588
10_D43_I0.760280.579
32_L71_F0.756420.576
16_G47_L0.752370.573
21_W28_Y0.751230.572
9_E13_E0.750620.572
19_R63_F0.747350.570
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3frmA199.10.034
3dddA199.10.049
1tiqA1990.072
2q0yA1990.074
3mgdA1990.085
2pdoA1990.093
2k5tA1990.093
4e2aA198.90.095
1kuxA198.90.096
3ec4A198.90.099

Page generated in 0.0151 seconds.