GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF4149 - Domain of unknown function (DUF4149)
Pfam: PF13664 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0430
Length: 101
Sequences: 473
Seq/Len: 4.68
HH_delta: 0.881 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
22_F30_A0.194561.946
4_A7_L0.191871.919
22_F38_F0.187791.878
30_A34_Q0.187031.870
46_L86_F0.163861.639
39_P42_F0.163141.631
2_L26_P0.162951.629
18_A30_A0.150771.508
21_L33_I0.145181.452
93_N97_D0.144711.447
6_W45_G0.144561.446
89_G93_N0.140931.409
22_F25_L0.139191.392
35_G93_N0.135861.359
42_F84_N0.134581.346
14_T39_P0.125951.259
28_Q31_G0.124511.245
31_G80_L0.123371.234
16_V23_K0.122881.229
21_L37_L0.122541.225
18_A22_F0.120521.205
34_Q42_F0.120181.202
14_T42_F0.118381.184
3_L52_L0.117731.177
13_F34_Q0.116611.166
6_W13_F0.11611.161
22_F31_G0.114491.145
38_F90_P0.11421.142
14_T41_Y0.114061.141
12_F17_V0.112841.128
63_S67_N0.110391.104
10_M13_F0.110121.101
9_S82_L0.110041.100
83_L88_L0.109141.091
11_V47_A0.107041.070
6_W77_M0.106481.065
5_L46_L0.106421.064
57_L76_V0.105731.057
33_I88_L0.105681.057
46_L80_L0.102581.026
7_L77_M0.10231.023
55_T59_L0.101271.013
37_L60_H0.100791.008
50_A57_L0.099150.991
91_K94_A0.098590.986
45_G57_L0.098580.986
3_L42_F0.098540.985
34_Q41_Y0.098060.981
68_R72_L0.097890.979
24_A79_L0.097170.972
79_L94_A0.097020.970
92_M96_K0.097010.970
9_S41_Y0.096480.965
34_Q39_P0.096210.962
40_K56_S0.09570.957
60_H70_Q0.095390.954
20_V40_K0.095260.953
76_V82_L0.095010.950
25_L74_L0.094650.946
89_G92_M0.09430.943
14_T18_A0.093290.933
63_S71_L0.093040.930
38_F42_F0.09220.922
17_V37_L0.092190.922
9_S75_L0.091970.920
59_L70_Q0.09130.913
71_L83_L0.091280.913
59_L71_L0.090930.909
26_P31_G0.090890.909
6_W17_V0.090740.907
74_L84_N0.090390.904
60_H83_L0.090210.902
13_F49_A0.089890.899
42_F96_K0.089690.897
91_K95_L0.089690.897
15_F84_N0.089590.896
24_A50_A0.089460.895
32_K51_V0.089410.894
11_V51_V0.089120.891
27_R34_Q0.088970.890
26_P29_Q0.08880.888
51_V54_L0.088730.887
11_V72_L0.08860.886
24_A33_I0.088560.886
65_N72_L0.088250.882
17_V21_L0.088150.881
7_L10_M0.088120.881
46_L82_L0.088060.881
42_F89_G0.087990.880
18_A93_N0.08790.879
39_P92_M0.087340.873
47_A56_S0.087340.873
58_A64_G0.087340.873
34_Q96_K0.087290.873
27_R33_I0.0870.870
32_K36_K0.08680.868
18_A34_Q0.085940.859
51_V71_L0.085850.858
18_A38_F0.085640.856
36_K79_L0.085530.855
67_N79_L0.085530.855
20_V33_I0.085350.853
78_L83_L0.085230.852
72_L83_L0.084750.847
26_P66_A0.084730.847
15_F96_K0.084620.846
36_K70_Q0.084440.844
58_A66_A0.084390.844
85_A89_G0.084320.843
78_L82_L0.084270.843
17_V20_V0.084080.841
15_F39_P0.083570.836
21_L30_A0.08340.834
23_K71_L0.083290.833
34_Q84_N0.083110.831
14_T34_Q0.083080.831
20_V32_K0.083080.831
1_L11_V0.083050.830
46_L57_L0.083010.830
48_C68_R0.082770.828
17_V23_K0.082590.826
5_L8_G0.082560.826
13_F33_I0.082370.824
12_F41_Y0.082360.824
24_A80_L0.082160.822
66_A83_L0.082020.820
86_F94_A0.082010.820
19_P35_G0.081960.820
49_A81_T0.081680.817
9_S72_L0.081550.815
26_P79_L0.081260.813
16_V81_T0.08120.812
5_L20_V0.08090.809
26_P65_N0.080820.808
4_A43_Y0.08020.802
58_A73_L0.080050.800
14_T30_A0.080010.800
14_T17_V0.080.800
13_F21_L0.079730.797
70_Q81_T0.079680.797
24_A54_L0.079440.794
37_L53_L0.079190.792
73_L94_A0.078640.786
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4k1cA0.930715.80.881
4apsA0.92086.20.9
3v5uA0.87132.70.915
4dx5A0.98022.50.916
3rqwA0.83172.40.917
4f4lA0.96042.20.918
4jbfA0.38612.10.919
4iu9B0.950520.92
3ne5A0.970320.921
3w9iA0.98021.90.921
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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