GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
PP2C_2 - Protein phosphatase 2C
Pfam: PF13672 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0238
Length: 212
Sequences: 4984
Seq/Len: 23.51
HH_delta: 0.285 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
102_L121_I1.09484.147
74_K78_L0.817963.098
74_K77_I0.786092.977
33_V98_G0.731912.772
120_R136_D0.698852.647
30_A99_T0.668742.533
113_I121_I0.66692.526
173_C178_W0.625592.369
110_K161_S0.616682.336
44_Q48_E0.583612.210
132_Q183_S0.570312.160
146_R149_T0.551022.087
111_V162_I0.546362.069
145_T148_L0.535652.029
104_L170_I0.523431.982
11_P40_E0.498291.887
126_R168_D0.488091.849
72_A76_E0.481551.824
145_T149_T0.472731.790
104_L172_L0.472551.790
73_I77_I0.471471.786
66_I73_I0.46251.752
70_I73_I0.457891.734
146_R150_G0.457781.734
110_K163_P0.451271.709
103_A114_F0.44961.703
113_I160_G0.44811.697
104_L111_V0.4481.697
70_I74_K0.447691.696
70_I77_I0.440241.667
69_L73_I0.419771.590
104_L113_I0.416991.579
173_C177_V0.416771.579
33_V36_S0.416041.576
112_Y161_S0.410751.556
137_H158_Q0.404541.532
69_L77_I0.400411.517
31_D175_D0.391191.482
120_R183_S0.391131.481
28_A47_V0.389771.476
28_A103_A0.386851.465
111_V170_I0.37771.431
30_A101_L0.372061.409
72_A77_I0.371791.408
15_A43_A0.367121.390
46_A99_T0.362981.375
115_N134_T0.360871.367
118_D175_D0.356271.349
125_R130_I0.35381.340
100_T119_S0.353331.338
165_E168_D0.351021.329
41_E45_L0.347871.318
45_L49_T0.343711.302
17_G28_A0.338121.281
66_I74_K0.33081.253
13_Q35_G0.325831.234
17_G51_I0.323421.225
177_V181_L0.316461.199
9_G12_N0.316371.198
99_T119_S0.315651.196
30_A47_V0.309261.171
100_T175_D0.309261.171
126_R165_E0.304641.154
102_L115_N0.300041.136
139_G142_P0.299961.136
124_I130_I0.298641.131
120_R134_T0.297931.128
188_E191_L0.293811.113
148_L151_D0.293331.111
115_N160_G0.281251.065
125_R168_D0.280691.063
139_G144_Q0.279271.058
75_K79_S0.279171.057
50_F101_L0.277721.052
124_I170_I0.277421.051
31_D118_D0.277341.050
123_V131_Q0.275871.045
53_Y57_L0.275111.042
39_G42_A0.274231.039
102_L172_L0.273911.037
188_E192_K0.273451.036
134_T137_H0.271171.027
184_Y189_Q0.270991.026
100_T118_D0.268271.016
182_R185_E0.266611.010
126_R129_E0.266271.009
32_G118_D0.259530.983
130_I191_L0.258790.980
120_R178_W0.258750.980
98_G101_L0.258490.979
66_I77_I0.256150.970
38_Y94_L0.255210.967
152_D155_P0.255130.966
49_T52_N0.253880.962
115_N121_I0.2520.954
112_Y159_Y0.250840.950
171_L187_L0.24990.946
9_G35_G0.249870.946
66_I69_L0.24790.939
122_Y173_C0.246710.934
121_I160_G0.243230.921
28_A50_F0.242710.919
164_L168_D0.242410.918
38_Y41_E0.240760.912
129_E188_E0.240140.910
147_S150_G0.239710.908
15_A40_E0.237990.901
115_N137_H0.235810.893
127_N165_E0.235280.891
187_L190_F0.234730.889
46_A49_T0.233690.885
102_L119_S0.23240.880
69_L74_K0.231670.877
121_I172_L0.231570.877
72_A75_K0.231490.877
51_I54_L0.228060.864
123_V170_I0.227630.862
13_Q40_E0.227270.861
35_G98_G0.227270.861
111_V164_L0.227220.861
39_G45_L0.226680.859
13_Q179_D0.226480.858
126_R167_G0.226430.858
15_A44_Q0.22620.857
26_L51_I0.225540.854
107_D110_K0.225210.853
171_L191_L0.224840.852
178_W187_L0.223150.845
115_N120_R0.220450.835
39_G98_G0.21690.822
177_V187_L0.216650.821
187_L191_L0.214150.811
147_S152_D0.213660.809
34_G39_G0.212060.803
66_I70_I0.211860.802
28_A101_L0.211540.801
57_L60_Q0.211530.801
46_A149_T0.209240.792
29_V172_L0.208760.791
39_G43_A0.207430.786
69_L78_L0.205840.780
30_A119_S0.204020.773
111_V114_F0.203670.771
17_G26_L0.203160.769
164_L170_I0.202750.768
87_A91_D0.202550.767
153_P156_D0.202230.766
126_R131_Q0.201510.763
109_D163_P0.201060.762
32_G119_S0.200470.759
75_K78_L0.199060.754
70_I78_L0.198640.752
123_V168_D0.198580.752
147_S151_D0.197480.748
132_Q136_D0.196030.742
45_L48_E0.195760.741
144_Q179_D0.194830.738
52_N76_E0.194710.737
26_L105_V0.192030.727
144_Q147_S0.191510.725
49_T53_Y0.191290.725
42_A122_Y0.19120.724
120_R173_C0.190910.723
68_A72_A0.190870.723
39_G46_A0.190030.720
68_A77_I0.188640.714
68_A73_I0.18830.713
34_G175_D0.188060.712
71_R75_K0.187230.709
13_Q39_G0.186270.706
32_G117_G0.183670.696
17_G30_A0.183030.693
106_I170_I0.1810.686
145_T150_G0.180960.685
32_G35_G0.180930.685
106_I111_V0.180490.684
107_D112_Y0.180440.683
73_I76_E0.179890.681
66_I76_E0.179860.681
73_I78_L0.179280.679
181_L190_F0.179170.679
120_R132_Q0.178340.675
61_E110_K0.176940.670
41_E44_Q0.176910.670
100_T104_L0.176240.668
44_Q47_V0.17580.666
189_Q192_K0.175580.665
32_G175_D0.175470.665
47_V51_I0.17440.661
13_Q37_P0.173370.657
79_S89_Q0.173290.656
67_E71_R0.172930.655
38_Y96_D0.172320.653
143_N146_R0.171530.650
76_E79_S0.171420.649
59_S68_A0.171280.649
159_Y162_I0.171110.648
119_S175_D0.170920.647
91_D94_L0.170670.646
112_Y115_N0.169810.643
68_A71_R0.169240.641
36_S39_G0.168780.639
141_Y144_Q0.168080.637
183_S187_L0.167990.636
163_P166_E0.167350.634
53_Y56_K0.1670.633
119_S178_W0.166720.631
173_C187_L0.166610.631
123_V167_G0.166290.630
20_T166_E0.166140.629
94_L97_Y0.166010.629
13_Q175_D0.165910.628
29_V102_L0.165730.628
116_I157_V0.165430.627
30_A100_T0.165350.626
72_A79_S0.164710.624
146_R151_D0.164450.623
130_I188_E0.163480.619
12_N39_G0.162430.615
33_V39_G0.162280.615
128_G192_K0.162030.614
127_N168_D0.161590.612
101_L114_F0.161270.611
51_I55_K0.161110.610
52_N56_K0.159620.605
46_A50_F0.15950.604
29_V47_V0.159310.603
119_S136_D0.158570.601
31_D176_G0.158450.600
115_N118_D0.158250.599
14_D31_D0.158120.599
42_A46_A0.158050.599
13_Q118_D0.157730.597
12_N16_F0.157450.596
187_L192_K0.156630.593
90_A94_L0.155980.591
24_G107_D0.155870.590
115_N122_Y0.155570.589
11_P174_S0.15350.581
26_L47_V0.153220.580
35_G42_A0.153140.580
33_V119_S0.153120.580
12_N115_N0.152850.579
106_I164_L0.152560.578
138_S179_D0.152230.577
13_Q32_G0.152140.576
133_L137_H0.151790.575
53_Y76_E0.15170.575
121_I133_L0.151580.574
46_A101_L0.151420.574
181_L187_L0.151270.573
185_E189_Q0.151240.573
88_K92_L0.150820.571
31_D34_G0.150770.571
33_V175_D0.150550.570
22_D110_K0.150370.570
184_Y188_E0.149960.568
35_G39_G0.149930.568
183_S188_E0.149050.565
133_L160_G0.149010.564
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2pk0A0.938799.90.285
4jndA0.948199.90.285
4da1A0.943499.90.289
1a6qA0.957599.90.289
2p8eA0.957599.90.289
3kdjB0.96799.90.291
2i0oA0.985899.90.294
2j82A0.93499.90.294
2i44A0.957599.90.296
3qn1B0.990699.90.296

Page generated in 0.041 seconds.