GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Acetyltransf_10 - Acetyltransferase (GNAT) domain
Pfam: PF13673 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0257
Length: 117
Sequences: 28264
Seq/Len: 241.57
HH_delta: 0.146 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
90_E117_F2.720812.721
83_R115_L2.539352.539
11_E73_L2.291532.291
59_A89_A2.180652.181
57_G72_V2.133542.133
56_V76_Y1.962951.963
88_A91_K1.949781.950
88_A92_E1.904661.905
109_R113_R1.903911.904
76_Y79_R1.873571.874
48_V55_I1.870451.870
83_R114_K1.852611.853
102_V112_Y1.83111.831
86_L115_L1.736621.737
47_F88_A1.733971.734
51_E76_Y1.732891.733
50_E55_I1.656031.656
110_R113_R1.653361.653
51_E56_V1.592431.592
49_A81_I1.58891.589
108_A112_Y1.571421.571
87_D115_L1.565761.566
105_N108_A1.534511.534
4_A7_E1.506181.506
59_A85_L1.48521.485
61_L89_A1.47731.477
4_A55_I1.460221.460
73_L76_Y1.452141.452
83_R87_D1.446981.447
47_F92_E1.37371.374
46_I60_W1.369311.369
92_E95_D1.365691.366
82_G111_F1.358851.359
84_A88_A1.345691.346
111_F115_L1.335911.336
54_E73_L1.297831.298
49_A85_L1.275321.275
11_E74_P1.266491.266
54_E75_E1.256581.257
61_L93_A1.247451.247
86_L117_F1.231471.231
51_E79_R1.217971.218
106_E109_R1.166561.167
80_G83_R1.150881.151
54_E76_Y1.149511.149
6_A10_R1.146421.146
36_E40_E1.134881.135
81_I84_A1.121331.121
7_E11_E1.107741.108
93_A100_L1.100851.101
87_D90_E1.08131.081
77_R107_R1.078111.078
4_A54_E1.076181.076
72_V81_I1.051751.052
86_L112_Y1.046081.046
3_P32_P1.041721.042
105_N109_R1.035641.036
90_E115_L1.02341.023
7_E73_L1.014461.014
91_K95_D1.012111.012
84_A87_D1.00241.002
106_E110_R1.002021.002
4_A8_L0.996970.997
3_P7_E0.98730.987
50_E53_G0.966780.967
58_F71_Y0.964320.964
87_D91_K0.948590.949
72_V82_G0.947780.948
91_K94_K0.946640.947
74_P77_R0.940390.940
90_E94_K0.920950.921
11_E75_E0.918310.918
12_A71_Y0.915930.916
90_E100_L0.915280.915
31_S34_D0.89310.893
70_L82_G0.881330.881
70_L86_L0.878240.878
93_A97_I0.873490.873
110_R114_K0.859490.859
49_A57_G0.85320.853
2_I6_A0.850780.851
32_P36_E0.835520.836
30_Y34_D0.83470.835
51_E54_E0.812930.813
15_E74_P0.809070.809
13_W16_N0.808140.808
8_L12_A0.798290.798
49_A84_A0.794170.794
9_Y58_F0.793890.794
70_L112_Y0.788470.788
1_D4_A0.786490.786
13_W71_Y0.784760.785
10_R14_Q0.784190.784
72_V77_R0.777980.778
4_A73_L0.768070.768
38_Y60_W0.767410.767
78_G107_R0.7670.767
8_L71_Y0.76520.765
62_E68_S0.759430.759
2_I36_E0.735930.736
9_Y13_W0.730150.730
107_R110_R0.727020.727
6_A32_P0.725690.726
60_W69_H0.724870.725
108_A111_F0.715710.716
56_V81_I0.713750.714
49_A56_V0.713660.714
35_L38_Y0.712820.713
33_E37_E0.710030.710
60_W68_S0.709120.709
76_Y81_I0.697980.698
1_D50_E0.694520.695
86_L111_F0.687610.688
37_E41_E0.687370.687
8_L55_I0.685560.686
102_V108_A0.683730.684
47_F50_E0.683140.683
31_S39_L0.682420.682
7_E10_R0.68050.680
112_Y117_F0.675140.675
38_Y44_H0.674340.674
3_P6_A0.668280.668
34_D38_Y0.665550.666
86_L90_E0.661620.662
45_T92_E0.658340.658
41_E44_H0.656780.657
102_V117_F0.655340.655
61_L92_E0.654140.654
100_L117_F0.652680.653
5_I58_F0.651170.651
8_L73_L0.646330.646
72_V85_L0.642630.643
33_E36_E0.642570.643
93_A96_G0.62840.628
85_L88_A0.617110.617
99_R102_V0.614280.614
57_G85_L0.60410.604
67_I86_L0.603480.603
30_Y35_L0.598520.599
4_A50_E0.595810.596
59_A70_L0.588960.589
17_Y20_Y0.578060.578
9_Y17_Y0.574440.574
59_A88_A0.573050.573
45_T61_L0.57170.572
12_A16_N0.571280.571
70_L111_F0.570640.571
7_E54_E0.56970.570
11_E15_E0.56420.564
8_L58_F0.549750.550
6_A9_Y0.546510.546
57_G81_I0.540730.541
2_I39_L0.540490.540
105_N110_R0.533840.534
46_I50_E0.529620.530
30_Y38_Y0.528920.529
9_Y69_H0.5270.527
67_I70_L0.522070.522
109_R112_Y0.519620.520
82_G85_L0.517810.518
16_N19_D0.51540.515
45_T48_V0.512690.513
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
1tiqA199.40.146
2q0yA0.982999.40.155
1kuxA0.931699.40.165
4e2aA199.40.174
1cjwA0.931699.40.178
3mgdA0.974499.40.183
3jvnA199.30.189
2dxqA0.940299.30.196
1wwzA0.965899.30.196
3gy9A0.931699.30.197

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