GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF4162 - Domain of unknown function (DUF4162)
Pfam: PF13732 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 84
Sequences: 7915
Seq/Len: 94.23
HH_delta: 0.767 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
1_G5_E2.205354.831
2_T5_E1.375873.014
16_T72_E1.058342.319
58_Q62_E1.050562.301
75_S78_D1.001672.194
58_Q61_I0.961382.106
59_E62_E0.908391.990
6_I79_I0.895541.962
1_G6_I0.894461.959
3_L7_K0.883711.936
74_P82_E0.823621.804
77_E81_I0.801441.756
1_G79_I0.777361.703
59_E63_K0.762541.670
68_S71_E0.752751.649
18_E68_S0.674281.477
55_E58_Q0.666711.461
34_S46_K0.660961.448
52_T55_E0.660831.448
3_L79_I0.63151.383
16_T70_E0.626691.373
57_L69_F0.625291.370
16_T44_R0.617391.353
76_L80_F0.611411.339
60_L65_I0.610451.337
53_A69_F0.596861.308
13_N73_E0.58231.276
54_N58_Q0.565281.238
57_L61_I0.565251.238
54_N61_I0.535731.174
4_E8_K0.524581.149
74_P79_I0.519481.138
58_Q64_G0.505181.107
15_I71_E0.504741.106
79_I83_V0.497241.089
19_T22_D0.491051.076
5_E9_Q0.489771.073
7_K10_Y0.470121.030
7_K79_I0.465011.019
14_K44_R0.461641.011
56_L60_L0.449170.984
20_D67_R0.44830.982
70_E73_E0.448050.982
18_E67_R0.436360.956
7_K75_S0.436090.955
57_L66_I0.435780.955
79_I82_E0.42750.937
75_S81_I0.425380.932
44_R47_L0.42170.924
77_E83_V0.409920.898
77_E80_F0.404650.886
80_F83_V0.397740.871
25_E63_K0.396260.868
24_E27_E0.395910.867
10_Y74_P0.391010.857
1_G9_Q0.379090.830
10_Y79_I0.378190.829
34_S37_Q0.373250.818
5_E8_K0.368740.808
75_S80_F0.368450.807
54_N57_L0.361020.791
18_E41_G0.359950.789
6_I83_V0.356220.780
73_E77_E0.355580.779
55_E59_E0.344340.754
7_K74_P0.342650.751
30_P34_S0.342580.750
19_T43_L0.339840.744
3_L6_I0.334910.734
44_R72_E0.326420.715
56_L59_E0.325930.714
26_L29_L0.322780.707
10_Y82_E0.321950.705
19_T65_I0.319690.700
71_E77_E0.315660.692
3_L83_V0.315110.690
10_Y83_V0.314610.689
21_G25_E0.313570.687
7_K69_F0.313160.686
6_I77_E0.309730.679
57_L60_L0.307160.673
49_D52_T0.306490.671
21_G24_E0.303480.665
28_E31_G0.301730.661
28_E33_E0.300240.658
71_E78_D0.298490.654
78_D81_I0.297430.652
17_I66_I0.296830.650
20_D54_N0.296660.650
3_L71_E0.294280.645
36_E41_G0.293540.643
12_K46_K0.293090.642
56_L61_I0.290840.637
14_K72_E0.290350.636
7_K73_E0.288480.632
33_E48_E0.28820.631
7_K81_I0.283590.621
37_Q41_G0.282770.619
11_G74_P0.281390.616
33_E40_D0.278760.611
36_E46_K0.274520.601
16_T19_T0.272930.598
43_L46_K0.27260.597
37_Q40_D0.266780.584
14_K46_K0.265940.583
54_N69_F0.26270.575
29_L59_E0.262530.575
24_E28_E0.262510.575
28_E51_E0.260310.570
51_E67_R0.258580.566
17_I69_F0.257840.565
33_E36_E0.257290.564
7_K80_F0.257010.563
1_G74_P0.256940.563
65_I81_I0.256840.563
61_I64_G0.251150.550
66_I69_F0.24940.546
16_T68_S0.249270.546
76_L81_I0.249180.546
15_I18_E0.248870.545
68_S72_E0.241510.529
3_L66_I0.241490.529
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3noyA0.91674.50.767
2fknA0.92864.10.772
1x87A0.928640.772
1uwkA0.928640.773
2wbrA0.690530.784
1y8xB0.79762.50.793
4gouA0.33331.80.808
3a5iA0.95241.50.815
4g9pA0.98811.40.818
3mixA0.95241.40.818
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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