GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Claudin_2 - PMP-22EMPMP20Claudin tight junction
Pfam: PF13903 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0375
Length: 172
Sequences: 1712
Seq/Len: 9.95
HH_delta: 0.918 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
13_T152_S0.344042.949
8_I12_G0.282412.421
73_A77_L0.269652.311
11_F75_L0.230451.975
10_A156_A0.226011.937
18_V150_G0.205421.761
44_G49_C0.204881.756
76_I80_L0.199251.708
120_I124_V0.195981.680
10_A159_A0.18861.617
5_I9_I0.179941.542
149_Y157_W0.179571.539
153_F157_W0.177491.521
15_Y42_H0.177211.519
84_F87_V0.172781.481
117_I121_V0.171151.467
13_T151_W0.168761.447
66_H70_A0.16841.443
89_A104_A0.165841.422
129_E138_P0.165491.419
113_L117_I0.164721.412
6_L155_L0.164061.406
6_L159_A0.161321.383
14_P47_R0.158961.363
105_G112_G0.158621.360
112_G169_L0.155471.333
115_I159_A0.15451.324
120_I123_V0.152751.309
3_A6_L0.147781.267
105_G167_G0.146291.254
15_Y151_W0.144951.242
99_T113_L0.144421.238
151_W155_L0.142171.219
55_D58_N0.141861.216
57_S60_N0.140911.208
46_W72_I0.140451.204
4_L83_L0.139481.196
83_L87_V0.138511.187
112_G164_L0.138191.185
118_A121_V0.137991.183
113_L120_I0.137391.178
70_A128_Y0.137381.178
3_A167_G0.136781.172
97_S105_G0.13591.165
68_M72_I0.135821.164
115_I119_L0.135191.159
57_S155_L0.134861.156
99_T110_L0.133771.147
82_L85_A0.132061.132
123_V126_V0.131331.126
6_L87_V0.131191.125
5_I12_G0.130811.121
75_L93_F0.130811.121
73_A80_L0.130541.119
11_F123_V0.127981.097
119_L156_A0.127891.096
43_S48_I0.127611.094
9_I13_T0.126711.086
3_A166_A0.126021.080
85_A104_A0.125421.075
75_L115_I0.124411.066
126_V147_Y0.123761.061
157_W167_G0.123081.055
106_I110_L0.123021.054
115_I160_F0.123021.054
13_T44_G0.122761.052
103_F111_A0.121471.041
109_I167_G0.121021.037
53_E56_S0.120671.034
12_G15_Y0.120371.032
67_W71_T0.119781.027
153_F166_A0.119461.024
154_W158_V0.119381.023
2_L128_Y0.119281.022
107_L110_L0.118881.019
123_V159_A0.118091.012
46_W160_F0.117741.009
73_A157_W0.11711.004
151_W165_L0.116030.995
11_F72_I0.1160.994
118_A122_F0.114680.983
85_A105_G0.113940.977
65_P122_F0.113530.973
118_A163_L0.113340.971
7_L82_L0.11330.971
24_T144_P0.112640.965
54_Y58_N0.112460.964
124_V153_F0.111920.959
10_A152_S0.111540.956
116_L160_F0.110970.951
70_A73_A0.110890.950
80_L145_F0.110650.948
106_I111_A0.110630.948
5_I161_I0.110190.944
78_G84_F0.10980.941
85_A113_L0.109050.935
129_E147_Y0.10880.933
103_F106_I0.108440.929
4_L82_L0.10840.929
103_F168_I0.107390.920
78_G115_I0.107130.918
2_L9_I0.107090.918
94_C97_S0.106860.916
19_S147_Y0.106110.910
161_I165_L0.105370.903
14_P116_L0.105330.903
7_L10_A0.105070.901
125_S147_Y0.104620.897
85_A125_S0.104330.894
2_L8_I0.104260.894
39_L56_S0.103760.889
154_W157_W0.10370.889
73_A76_I0.103650.888
68_M92_G0.103560.888
24_T110_L0.103430.887
78_G111_A0.103250.885
113_L160_F0.103230.885
3_A163_L0.102250.876
70_A76_I0.10220.876
116_L120_I0.10210.875
22_R25_G0.102020.874
92_G95_K0.101790.872
69_R73_A0.101620.871
113_L164_L0.100610.862
70_A88_F0.100380.860
43_S122_F0.10020.859
125_S144_P0.100160.859
24_T146_S0.100130.858
69_R76_I0.099810.856
152_S161_I0.099790.855
148_S158_V0.099380.852
105_G108_F0.098990.848
112_G168_I0.098670.846
41_S50_F0.098610.845
2_L155_L0.09860.845
148_S154_W0.098560.845
119_L153_F0.098230.842
122_F127_N0.098040.840
19_S122_F0.096960.831
93_F96_R0.096410.826
100_L103_F0.096340.826
158_V165_L0.095980.823
23_R53_E0.095690.820
7_L160_F0.095520.819
159_A167_G0.095440.818
45_L49_C0.095360.817
113_L129_E0.09520.816
60_N138_P0.095130.815
80_L86_F0.094510.810
55_D61_E0.094380.809
103_F109_I0.094350.809
20_D146_S0.094160.807
8_I125_S0.094060.806
81_L107_L0.094050.806
17_V43_S0.093970.805
119_L160_F0.093860.805
98_Y110_L0.093840.804
7_L106_I0.093460.801
104_A115_I0.093150.798
88_F115_I0.093110.798
79_L88_F0.093020.797
115_I143_S0.09290.796
90_L110_L0.092870.796
91_I166_A0.092850.796
24_T40_F0.092780.795
113_L146_S0.092760.795
5_I13_T0.092660.794
129_E139_P0.092540.793
99_T102_L0.092510.793
121_V127_N0.092370.792
118_A145_F0.092250.791
55_D150_G0.091730.786
55_D59_R0.091390.783
82_L163_L0.091390.783
117_I168_I0.091210.782
112_G167_G0.091190.782
9_I12_G0.091140.781
48_I103_F0.090960.780
8_I14_P0.090920.779
115_I120_I0.090370.775
106_I109_I0.090340.774
52_R56_S0.090220.773
49_C167_G0.090210.773
99_T166_A0.090040.772
9_I79_L0.089970.771
74_F118_A0.089960.771
86_F111_A0.089940.771
6_L162_L0.08990.771
88_F107_L0.089840.770
109_I117_I0.089780.770
139_P148_S0.089410.766
95_K105_G0.089310.766
10_A91_I0.089280.765
70_A81_L0.089230.765
84_F117_I0.089170.764
10_A115_I0.089050.763
44_G52_R0.088740.761
97_S110_L0.088250.756
17_V122_F0.088160.756
66_H69_R0.088130.755
39_L54_Y0.088120.755
123_V149_Y0.088070.755
12_G86_F0.087430.749
51_Q57_S0.087220.748
110_L118_A0.087160.747
2_L106_I0.0870.746
115_I152_S0.086970.745
60_N88_F0.086820.744
45_L128_Y0.086280.740
77_L80_L0.08620.739
85_A166_A0.08610.738
67_W122_F0.086090.738
56_S59_R0.086030.737
104_A108_F0.085990.737
59_R62_T0.085980.737
52_R57_S0.08570.735
79_L154_W0.085590.734
74_F90_L0.08520.730
11_F91_I0.085060.729
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
2rh1A0.75130.918
2lk9A0.20357.30.926
4dklA0.61056.50.928
2y69M0.17445.80.929
4av3A0.77915.70.93
4eiyA0.69775.50.93
1v54M0.174450.931
4grvA0.720950.931
3rzeA0.5644.80.932
3pblA0.74424.80.932
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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