GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
ATC_hydrolase - L-2-amino-thiazoline-4-carboxylic acid hydrolase
Pfam: PF14196 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 149
Sequences: 947
Seq/Len: 6.36
HH_delta: 0.623 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
136_K142_D0.256742.494
134_R137_T0.23912.323
93_D146_D0.206992.011
49_G125_G0.19721.916
134_R138_L0.16321.585
39_E42_R0.16191.573
120_Y132_L0.158381.538
50_K54_E0.155531.511
137_T146_D0.15551.510
136_K146_D0.154221.498
29_G32_E0.149831.455
97_C119_D0.147371.431
35_E75_S0.145991.418
35_E50_K0.142691.386
136_K144_C0.141621.376
93_D144_C0.140661.366
136_K143_D0.140021.360
62_D65_K0.137081.332
73_Y79_F0.135621.317
65_K69_M0.134831.310
103_W119_D0.130741.270
97_C116_C0.13071.270
22_K105_E0.129871.261
24_L27_E0.129521.258
142_D146_D0.128791.251
23_A43_R0.127361.237
71_K74_P0.123951.204
63_F90_F0.123921.204
94_F119_D0.123351.198
137_T147_F0.123181.197
69_M78_V0.12271.192
52_L76_D0.122381.189
69_M72_D0.121831.183
54_E58_R0.121721.182
41_I45_G0.119971.165
80_E96_R0.119671.162
81_E95_T0.119511.161
51_A55_R0.119051.156
44_F48_R0.11851.151
99_Y123_A0.118291.149
43_R46_R0.118211.148
91_E146_D0.117741.144
54_E57_R0.116991.136
16_W20_L0.116491.132
49_G53_A0.116191.129
95_T138_L0.115641.123
55_R68_E0.113831.106
99_Y147_F0.11251.093
120_Y134_R0.11181.086
95_T143_D0.111531.083
67_A86_D0.110481.073
91_E148_R0.110221.071
71_K75_S0.109551.064
70_M78_V0.107811.047
16_W98_P0.107751.047
23_A27_E0.10691.038
48_R115_Y0.106131.031
30_P50_K0.104971.020
137_T142_D0.104951.019
15_F19_A0.104681.017
28_M33_A0.103791.008
53_A125_G0.103721.007
95_T144_C0.102981.000
135_T146_D0.102780.998
63_F86_D0.102220.993
81_E135_T0.10190.990
123_A127_N0.101870.990
73_Y94_F0.101470.986
116_C145_C0.101260.984
66_F70_M0.101190.983
85_D88_D0.100920.980
120_Y123_A0.100240.974
118_I122_M0.100110.972
94_F147_F0.099650.968
25_I34_E0.09960.967
32_E46_R0.099320.965
67_A75_S0.099190.963
42_R121_A0.098980.961
69_M77_W0.098230.954
94_F103_W0.098060.953
64_E85_D0.096910.941
137_T141_G0.096210.935
55_R75_S0.095810.931
46_R50_K0.095750.930
45_G48_R0.095190.925
96_R101_E0.095140.924
21_Y33_A0.094830.921
85_D89_E0.094720.920
23_A28_M0.094310.916
79_F98_P0.093870.912
52_L69_M0.093830.911
76_D137_T0.093310.906
92_F142_D0.0930.903
117_D135_T0.092770.901
47_K50_K0.092710.901
96_R103_W0.092540.899
52_L79_F0.092330.897
87_E90_F0.09230.897
58_R83_V0.092110.895
54_E67_A0.09180.892
96_R99_Y0.091630.890
30_P105_E0.091290.887
41_I115_Y0.091230.886
45_G118_I0.090750.882
133_E136_K0.090610.880
112_G132_L0.090540.879
96_R119_D0.090520.879
49_G104_K0.090250.877
73_Y77_W0.089980.874
57_R60_P0.089760.872
79_F94_F0.089490.869
112_G115_Y0.08890.864
43_R61_D0.08850.860
135_T148_R0.088460.859
18_Y138_L0.088420.859
67_A85_D0.088360.858
54_E125_G0.08830.858
98_P119_D0.088230.857
81_E93_D0.087960.854
57_R61_D0.087860.853
27_E39_E0.087280.848
40_A44_F0.086970.845
53_A61_D0.086830.843
77_W132_L0.086820.843
82_V90_F0.086770.843
17_F117_D0.086740.843
78_V96_R0.086580.841
112_G119_D0.086580.841
124_E129_G0.086580.841
134_R146_D0.086470.840
120_Y126_F0.08630.838
97_C145_C0.086130.837
97_C138_L0.085880.834
25_I113_P0.085010.826
55_R143_D0.084790.824
27_E47_K0.084760.823
51_A87_E0.084430.820
98_P125_G0.084360.819
24_L124_E0.084350.819
94_F98_P0.084330.819
86_D89_E0.084210.818
46_R57_R0.083970.816
72_D75_S0.083790.814
99_Y134_R0.083310.809
134_R147_F0.083260.809
84_E124_E0.083220.808
98_P147_F0.08260.802
114_I139_A0.08260.802
96_R138_L0.082580.802
64_E84_E0.082550.802
22_K30_P0.082240.799
44_F72_D0.082140.798
40_A48_R0.082060.797
45_G94_F0.081950.796
78_V94_F0.081760.794
62_D69_M0.08170.794
42_R55_R0.081680.793
30_P101_E0.081480.791
50_K68_E0.081460.791
63_F88_D0.080720.784
61_D71_K0.080580.783
62_D127_N0.080320.780
33_A122_M0.080140.778
46_R125_G0.080040.777
25_I114_I0.079850.776
26_E58_R0.079850.776
33_A40_A0.079840.776
68_E71_K0.079770.775
22_K26_E0.079550.773
52_L119_D0.079490.772
52_L66_F0.079280.770
18_Y21_Y0.079120.769
117_D144_C0.079080.768
30_P133_E0.079060.768
78_V119_D0.079010.767
45_G73_Y0.078810.766
56_M65_K0.078610.764
22_K43_R0.078450.762
73_Y119_D0.078360.761
79_F99_Y0.078360.761
30_P39_E0.077770.755
41_I77_W0.077710.755
98_P118_I0.077630.754
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2osoA0.865898.80.623
2c0jB0.919588.40.851
1sz7A0.979987.90.853
2bjnA0.919587.80.853
2j3wB0.9597860.857
3cueD0.966482.30.863
2kiiA0.892676.60.87
3tfgA0.90673.20.873
2z9eA0.966463.50.881
3aj1A0.899356.20.886
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