GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF4320 - Domain of unknown function (DUF4320)
Pfam: PF14208 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 116
Sequences: 652
Seq/Len: 5.62
HH_delta: 0.906 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
32_L50_I0.363673.379
25_L103_I0.24832.307
47_V51_E0.238732.218
36_A80_V0.222582.068
25_L84_V0.221262.056
24_Q32_L0.191081.775
83_T106_K0.178731.661
83_T104_R0.175681.632
14_S17_P0.173361.611
33_V37_E0.171931.597
29_A107_A0.170731.586
28_F32_L0.165431.537
81_T106_K0.164671.530
21_Q50_I0.163351.518
29_A37_E0.161691.502
81_T108_S0.160511.491
29_A84_V0.14381.336
26_N91_G0.135361.258
21_Q25_L0.133071.236
17_P88_Y0.131161.219
32_L82_V0.127571.185
6_M10_A0.126741.178
14_S20_I0.126171.172
11_L31_E0.126091.171
44_S83_T0.124811.160
10_A30_Q0.122281.136
18_V88_Y0.121271.127
20_I24_Q0.121231.126
32_L36_A0.120561.120
23_Q27_T0.120461.119
27_T31_E0.119251.108
27_T36_A0.119131.107
36_A46_T0.118391.100
95_G101_I0.117231.089
30_Q41_G0.116541.083
16_F19_F0.114951.068
45_E52_D0.113511.055
12_I16_F0.113331.053
75_Q78_E0.113281.052
18_V21_Q0.113251.052
47_V52_D0.113131.051
36_A57_T0.111011.031
48_D51_E0.110051.022
19_F23_Q0.109821.020
18_V34_R0.10811.004
8_L26_N0.107741.001
11_L20_I0.106740.992
54_S63_I0.106280.987
14_S24_Q0.10610.986
32_L46_T0.105110.977
27_T59_L0.103760.964
34_R82_V0.102370.951
7_F106_K0.102250.950
85_T101_I0.101840.946
10_A21_Q0.101780.946
76_L97_G0.101550.943
87_E100_P0.101270.941
81_T104_R0.101130.940
20_I30_Q0.100160.931
27_T30_Q0.100130.930
19_F92_I0.09960.925
33_V84_V0.099160.921
66_S106_K0.099060.920
47_V80_V0.098740.917
35_Q105_A0.098150.912
6_M60_D0.097910.910
17_P91_G0.097250.904
64_S88_Y0.097050.902
29_A45_E0.096860.900
18_V26_N0.095630.888
4_I32_L0.095550.888
24_Q107_A0.095070.883
24_Q27_T0.094570.879
47_V83_T0.093320.867
7_F38_R0.093260.866
35_Q45_E0.093210.866
85_T96_F0.092980.864
44_S58_G0.092440.859
43_T83_T0.092150.856
48_D62_M0.092030.855
42_V81_T0.091510.850
6_M101_I0.091360.849
4_I7_F0.091140.847
28_F37_E0.091090.846
5_A18_V0.090860.844
5_A16_F0.090430.840
87_E106_K0.089740.834
50_I84_V0.089450.831
25_L105_A0.089370.830
85_T104_R0.08890.826
39_E94_K0.08850.822
12_I46_T0.088230.820
4_I15_V0.087850.816
8_L31_E0.087450.812
4_I83_T0.087290.811
22_K25_L0.087230.810
11_L32_L0.087110.809
14_S89_K0.087070.809
10_A75_Q0.087020.808
14_S95_G0.086280.802
31_E49_R0.086170.801
4_I100_P0.086010.799
54_S106_K0.085950.799
45_E48_D0.085770.797
26_N80_V0.085610.795
49_R81_T0.085610.795
37_E86_G0.08510.791
60_D64_S0.085040.790
11_L23_Q0.084950.789
87_E102_T0.084750.787
26_N105_A0.083920.780
29_A82_V0.083710.778
26_N86_G0.083450.775
23_Q41_G0.083190.773
22_K107_A0.083050.772
5_A8_L0.082630.768
37_E107_A0.082630.768
77_N97_G0.082620.768
16_F65_W0.082540.767
12_I106_K0.082370.765
25_L86_G0.082120.763
36_A42_V0.082090.763
60_D89_K0.081590.758
15_V19_F0.081540.758
19_F34_R0.081360.756
20_I88_Y0.081320.756
86_G103_I0.08120.754
28_F55_E0.081140.754
59_L63_I0.080610.749
44_S102_T0.080450.747
29_A88_Y0.079430.738
33_V86_G0.079150.735
9_I45_E0.078870.733
62_M104_R0.078730.731
17_P26_N0.078540.730
7_F20_I0.07840.728
11_L108_S0.078240.727
61_P91_G0.078180.726
33_V36_A0.078170.726
31_E38_R0.078120.726
52_D64_S0.078080.725
18_V90_I0.077930.724
17_P20_I0.077790.723
12_I90_I0.077770.723
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
4ainA0.448313.60.906
4ixqK0.17248.80.913
3arcK0.17247.80.915
3filA0.26723.80.926
2qjyB0.33623.40.927
3cx5D0.33623.30.928
1lghA0.30172.70.931
1xo8A0.8192.50.932
2yizA0.57762.30.933
4gosA0.48282.20.934
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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