GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF4369 - Domain of unknown function (DUF4369)
Pfam: PF14289 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 106
Sequences: 844
Seq/Len: 7.96
HH_delta: 0.867 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
17_G50_F0.622614.476
13_F54_G0.568674.088
29_Y42_S0.341932.458
29_Y41_D0.306372.202
18_K49_K0.297442.138
43_V52_F0.287932.070
81_G99_S0.281582.024
27_K44_V0.25551.837
54_G78_L0.232081.668
27_K42_S0.227561.636
84_T97_S0.221231.590
14_T53_K0.219911.581
46_K49_K0.21591.552
30_L52_F0.213441.534
41_D52_F0.211291.519
13_F78_L0.209691.507
99_S102_N0.205611.478
42_S52_F0.196141.410
16_E84_T0.195591.406
12_Q80_P0.189021.359
86_N95_K0.186111.338
100_K103_D0.183461.319
18_K86_N0.182911.315
19_I87_G0.181761.307
12_Q55_P0.181241.303
100_K104_E0.172731.242
15_I83_I0.172431.239
12_Q53_K0.169621.219
26_D77_F0.16651.197
72_G94_I0.164041.179
19_I88_D0.162551.168
76_F85_I0.157411.132
61_F77_F0.152041.093
79_E101_L0.15141.088
21_G76_F0.14811.065
74_V94_I0.14441.038
101_L104_E0.144171.036
22_L45_V0.141121.014
14_T82_D0.139081.000
54_G79_E0.138110.993
62_Y78_L0.1370.985
21_G87_G0.135910.977
19_I39_V0.135670.975
77_F101_L0.134780.969
59_P64_L0.134510.967
43_V54_G0.134090.964
64_L85_I0.131790.947
83_I99_S0.131130.943
33_Y37_K0.13070.940
15_I85_I0.129980.934
16_E51_S0.126990.913
97_S103_D0.125280.901
12_Q28_V0.124490.895
59_P79_E0.123650.889
79_E82_D0.123360.887
14_T51_S0.121430.873
30_L43_V0.120980.870
6_C98_G0.120190.864
77_F81_G0.120020.863
56_L60_G0.11870.853
24_D46_K0.117450.844
69_G91_N0.117130.842
17_G79_E0.1170.841
49_K84_T0.116660.839
7_A46_K0.115920.833
37_K40_I0.115820.833
75_P78_L0.115270.829
30_L42_S0.113830.818
32_Y40_I0.113830.818
39_V76_F0.113350.815
97_S102_N0.113190.814
30_L54_G0.112350.808
60_G101_L0.112090.806
77_F102_N0.111340.800
61_F75_P0.111030.798
8_Q40_I0.109660.788
35_N88_D0.109210.785
42_S45_V0.108730.782
15_I64_L0.108640.781
98_G103_D0.10830.778
96_V99_S0.108170.778
22_L69_G0.108060.777
6_C75_P0.107940.776
84_T96_V0.10780.775
28_V87_G0.107360.772
78_L81_G0.107310.771
32_Y72_G0.104810.753
52_F64_L0.104480.751
25_G77_F0.103660.745
72_G87_G0.103050.741
30_L76_F0.102990.740
33_Y36_G0.102130.734
45_V89_A0.101870.732
7_A88_D0.100940.726
35_N38_V0.100160.720
81_G101_L0.100120.720
5_S31_Y0.100060.719
35_N89_A0.099740.717
51_S55_P0.099210.713
32_Y62_Y0.098680.709
56_L78_L0.098630.709
84_T95_K0.09820.706
25_G99_S0.097910.704
15_I62_Y0.097710.702
11_K55_P0.097530.701
16_E40_I0.097490.701
16_E49_K0.0970.697
48_G78_L0.096940.697
18_K37_K0.096490.694
33_Y38_V0.095970.690
85_I91_N0.095950.690
22_L87_G0.095680.688
79_E99_S0.095330.685
21_G45_V0.095220.684
12_Q73_Y0.094830.682
60_G104_E0.094780.681
18_K79_E0.094330.678
56_L80_P0.094210.677
28_V47_N0.094140.677
37_K64_L0.093770.674
20_K48_G0.093720.674
29_Y35_N0.093090.669
59_P62_Y0.093070.669
53_K73_Y0.092960.668
48_G83_I0.092880.668
6_C58_E0.092730.667
83_I102_N0.092530.665
7_A38_V0.092030.662
59_P78_L0.091940.661
71_K87_G0.091770.660
8_Q47_N0.090560.651
38_V72_G0.090330.649
18_K84_T0.090280.649
33_Y83_I0.089950.647
7_A33_Y0.089940.647
33_Y63_Y0.089940.647
57_D71_K0.08990.646
16_E64_L0.089440.643
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
1nkgA0.9245210.867
1h8lA0.79259.50.885
2diaA0.88689.30.886
3txaA0.7837.50.89
3zr5A0.9346.90.891
1uwyA0.89626.60.892
2dlgA0.88686.60.892
4fmvA0.66986.40.893
3vu1A0.89624.20.901
2xvlA0.91513.70.903
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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