GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
GST_C_3 - Glutathione S-transferase C-terminal domain
Pfam: PF14497 (v27) Consensus Sequence
Clan: CL0497
Length: 99
Sequences: 5368
Seq/Len: 54.22
HH_delta: 0.144 (11Mar13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
92_R96_R1.781194.064
55_G96_R1.198052.733
52_A89_N1.150552.625
48_E89_N1.066762.434
59_L71_V0.91122.079
64_P69_I0.88762.025
45_K87_Y0.827911.889
55_G62_D0.798751.822
50_H54_R0.78971.802
8_L11_R0.778671.777
89_N92_R0.770581.758
91_V95_E0.741191.691
34_D38_E0.728091.661
12_W50_H0.690241.575
30_E34_D0.688591.571
60_V65_T0.677721.546
10_D14_D0.668411.525
41_P86_D0.667441.523
45_K49_K0.665171.518
29_D32_S0.655821.496
72_F98_E0.647651.478
48_E52_A0.646181.474
72_F97_I0.644091.469
13_L66_L0.631431.441
48_E88_P0.628151.433
5_W63_K0.60651.384
39_E42_K0.566331.292
50_H53_E0.56621.292
13_L70_A0.548481.251
35_F39_E0.548321.251
18_A22_R0.537181.226
59_L67_A0.534261.219
37_R41_P0.496611.133
46_I50_H0.489291.116
41_P45_K0.487371.112
9_I67_A0.48691.111
6_R10_D0.485651.108
93_W97_I0.482531.101
16_S71_V0.482061.100
30_E33_G0.473961.081
85_K91_V0.472081.077
95_E98_E0.471291.075
12_W15_F0.466181.064
59_L93_W0.455591.039
47_L59_L0.454491.037
64_P97_I0.451431.030
58_F96_R0.445161.016
49_K52_A0.430940.983
47_L71_V0.429830.981
7_A11_R0.428720.978
60_V67_A0.423530.966
15_F43_A0.409980.935
44_L90_L0.406390.927
9_I65_T0.405820.926
8_L12_W0.403650.921
40_L44_L0.393480.898
12_W59_L0.39310.897
20_R23_K0.392490.895
34_D37_R0.3910.892
35_F38_E0.386380.882
76_A98_E0.384060.876
53_E89_N0.381370.870
70_A74_F0.379410.866
38_E42_K0.376490.859
49_K53_E0.376210.858
58_F64_P0.374440.854
45_K86_D0.374040.853
9_I60_V0.371560.848
41_P87_Y0.371230.847
9_I66_L0.368730.841
24_A28_K0.366640.836
18_A21_R0.365070.833
36_S39_E0.361260.824
87_Y90_L0.356280.813
50_H59_L0.351650.802
24_A27_E0.349850.798
22_R25_R0.347150.792
54_R62_D0.342330.781
75_L93_W0.341390.779
42_K46_I0.34050.777
40_L75_L0.339670.775
61_G68_D0.33570.766
94_Y98_E0.334220.763
31_A34_D0.332730.759
19_F23_K0.328830.750
25_R28_K0.327120.746
82_D86_D0.324560.740
5_W9_I0.324240.740
31_A35_F0.318480.727
58_F97_I0.318170.726
48_E87_Y0.317390.724
92_R95_E0.314910.718
18_A24_A0.312230.712
8_L54_R0.311980.712
28_K33_G0.311060.710
59_L90_L0.307990.703
75_L90_L0.306410.699
32_S36_S0.306250.699
10_D13_L0.303020.691
18_A23_K0.299240.683
27_E30_E0.29840.681
15_F46_I0.297260.678
38_E41_P0.295160.673
16_S74_F0.292450.667
55_G92_R0.292150.667
66_L70_A0.289290.660
23_K80_W0.2890.659
61_G65_T0.288360.658
47_L75_L0.288330.658
42_K45_K0.285770.652
44_L87_Y0.283750.647
33_G37_R0.280540.640
74_F77_S0.276610.631
58_F61_G0.276220.630
73_G77_S0.273060.623
7_A10_D0.271840.620
7_A14_D0.269450.615
48_E90_L0.267840.611
16_S40_L0.26720.610
5_W8_L0.265180.605
69_I97_I0.265040.605
48_E92_R0.263940.602
19_F22_R0.260420.594
60_V64_P0.259690.592
21_R24_A0.25960.592
15_F71_V0.254390.580
33_G36_S0.252730.577
51_L89_N0.251090.573
82_D85_K0.249240.569
5_W49_K0.248930.568
77_S94_Y0.24860.567
47_L90_L0.248550.567
60_V63_K0.248390.567
46_I49_K0.247810.565
30_E36_S0.246690.563
8_L50_H0.245690.561
60_V93_W0.245590.560
78_L83_F0.244020.557
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3vk9A0.969799.30.144
4hi7A0.979899.30.16
4gltA0.979899.30.165
4gciA0.969799.20.169
3lypA0.969799.20.181
3lykA0.979899.20.188
4gf0A0.969799.20.188
3n5oA0.989999.20.189
3einA0.969799.20.193
3gx0A0.969799.20.196

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