GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
GST_C_3 - Glutathione S-transferase C-terminal domain
Pfam: PF14497 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0497
Length: 99
Sequences: 7645
Seq/Len: 77.22
HH_delta: 0.225 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
92_R96_R1.8793.512
55_G96_R1.641223.067
48_E89_N1.383922.586
52_A89_N1.306282.441
64_P69_I1.089362.036
59_L71_V1.076842.012
45_K87_Y1.052351.967
55_G62_D0.986431.844
72_F97_I0.957831.790
50_H54_R0.951331.778
8_L11_R0.949661.775
89_N92_R0.936851.751
41_P86_D0.902291.686
91_V95_E0.898931.680
12_W50_H0.855491.599
30_E34_D0.84441.578
60_V65_T0.829521.550
34_D38_E0.819141.531
29_D32_S0.780831.459
72_F98_E0.764071.428
4_Y8_L0.760741.422
48_E88_P0.735811.375
10_D14_D0.723041.351
39_E42_K0.718991.344
13_L66_L0.700241.309
18_A22_R0.690941.291
64_P97_I0.682931.276
46_I50_H0.675581.263
35_F39_E0.675091.262
59_L67_A0.671231.254
45_K49_K0.663861.241
34_D37_R0.662871.239
13_L70_A0.65911.232
82_D85_K0.645321.206
48_E52_A0.644591.205
95_E98_E0.631311.180
9_I60_V0.622741.164
37_R41_P0.603741.128
5_W63_K0.594421.111
41_P45_K0.587121.097
15_F43_A0.586251.096
85_K91_V0.582541.089
9_I67_A0.580281.084
93_W97_I0.575321.075
18_A21_R0.571341.068
16_S71_V0.569391.064
6_R10_D0.566461.059
50_H59_L0.552131.032
54_R62_D0.549191.026
50_H53_E0.546771.022
45_K86_D0.542911.015
47_L71_V0.540471.010
38_E41_P0.539541.008
30_E33_G0.539421.008
12_W15_F0.530730.992
7_A11_R0.529670.990
14_D17_V0.525020.981
9_I65_T0.514280.961
47_L59_L0.507230.948
38_E42_K0.503290.941
70_A74_F0.501770.938
49_K52_A0.499570.934
76_A98_E0.495440.926
82_D86_D0.494320.924
58_F97_I0.491030.918
58_F96_R0.484190.905
36_S39_E0.482010.901
41_P87_Y0.480850.899
32_S36_S0.477850.893
92_R95_E0.472510.883
19_F22_R0.469620.878
94_Y98_E0.464530.868
60_V67_A0.460390.860
55_G92_R0.45950.859
8_L54_R0.453680.848
49_K53_E0.445980.833
46_I49_K0.441110.824
48_E87_Y0.439140.821
59_L93_W0.433480.810
18_A24_A0.424780.794
35_F38_E0.420870.787
5_W8_L0.413450.773
75_L93_W0.409840.766
12_W59_L0.40970.766
18_A23_K0.403760.755
21_R24_A0.403630.754
59_L90_L0.402860.753
20_R31_A0.397280.742
15_F46_I0.395060.738
6_R9_I0.383510.717
48_E90_L0.382110.714
27_E30_E0.381990.714
66_L70_A0.38090.712
40_L44_L0.379890.710
42_K45_K0.377640.706
16_S74_F0.37690.704
42_K46_I0.372640.696
20_R25_R0.371710.695
20_R24_A0.366610.685
31_A34_D0.362510.677
5_W9_I0.360890.674
71_V75_L0.359080.671
39_E43_A0.355270.664
86_D91_V0.350330.655
75_L94_Y0.348270.651
7_A10_D0.348140.651
44_L87_Y0.345580.646
19_F23_K0.345570.646
75_L90_L0.343510.642
69_I93_W0.336370.629
9_I13_L0.33330.623
44_L90_L0.331630.620
47_L90_L0.327850.613
24_A28_K0.322710.603
52_A55_G0.315450.590
79_R98_E0.31470.588
87_Y90_L0.314520.588
79_R84_P0.313660.586
26_L29_D0.311840.583
8_L12_W0.309680.579
76_A80_W0.306350.573
21_R28_K0.305090.570
8_L50_H0.304790.570
73_G93_W0.304120.568
91_V94_Y0.301190.563
64_P72_F0.300960.562
26_L30_E0.300280.561
22_R26_L0.295620.552
54_R96_R0.294050.550
12_W60_V0.291010.544
47_L75_L0.289480.541
73_G77_S0.288470.539
60_V63_K0.287630.538
58_F61_G0.286430.535
88_P91_V0.285620.534
21_R36_S0.283920.531
23_K80_W0.283650.530
24_A27_E0.281970.527
58_F64_P0.280530.524
74_F77_S0.279180.522
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
2hnlA199.20.225
3q18A199.20.226
3vlnA199.20.236
3rbtA0.979899.20.236
3vk9A0.979899.20.238
3h1nA199.20.238
1b8xA0.979899.20.244
3lxzA0.979899.20.246
1vf1A199.20.246
4ikhA0.969799.10.249

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