GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Acetyltransf_CG - GCN5-related N-acetyl-transferase
Pfam: PF14542 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0257
Length: 78
Sequences: 30724
Seq/Len: 393.9
HH_delta: 0.107 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
14_L47_A2.754272.489
12_A30_V2.200241.989
34_L37_Q2.098171.896
46_A50_Y1.906461.723
11_I34_L1.860091.681
62_C65_V1.820251.645
50_Y54_N1.819341.644
46_A49_D1.803821.630
14_L43_L1.802631.629
66_A70_R1.771621.601
16_Y47_A1.682461.521
67_K70_R1.674751.514
41_K71_R1.601741.448
13_E29_E1.587961.435
65_V69_F1.573171.422
31_P34_L1.567741.417
41_K45_E1.555161.406
6_D11_I1.493511.350
42_K46_A1.467261.326
25_I44_V1.422881.286
6_D34_L1.409641.274
16_Y51_A1.401151.266
9_E34_L1.4011.266
23_I56_L1.399791.265
28_T40_A1.399321.265
50_Y53_E1.395891.262
39_I42_K1.347491.218
30_V35_R1.286281.163
28_T69_F1.276331.154
17_R26_T1.274551.152
15_T27_H1.261951.141
23_I51_A1.243441.124
18_E56_L1.234731.116
44_V69_F1.211781.095
28_T44_V1.200271.085
15_T26_T1.197031.082
32_P35_R1.165641.054
49_D53_E1.163591.052
18_E23_I1.155761.045
30_V40_A1.144871.035
9_E33_E1.135331.026
17_R24_V1.120191.012
63_S66_A1.118621.011
42_K45_E1.116531.009
24_V27_H1.091820.987
66_A69_F1.076730.973
48_L52_R1.072640.970
30_V39_I1.071520.969
13_E27_H1.048710.948
45_E48_L1.032330.933
9_E31_P1.012910.916
41_K68_Y1.004290.908
44_V48_L0.969040.876
67_K71_R0.968870.876
63_S67_K0.946490.855
16_Y23_I0.938690.848
51_A56_L0.937740.848
38_G41_K0.929030.840
40_A68_Y0.918020.830
12_A39_I0.910480.823
35_R64_Y0.879750.795
45_E49_D0.876270.792
30_V43_L0.866890.784
22_V58_V0.849870.768
11_I31_P0.84060.760
65_V68_Y0.80680.729
40_A44_V0.798960.722
34_L39_I0.795840.719
14_L28_T0.774370.700
6_D9_E0.76790.694
19_D22_V0.762860.690
10_E13_E0.75570.683
43_L46_A0.753630.681
25_I69_F0.746530.675
62_C66_A0.741940.671
16_Y50_Y0.735010.664
22_V26_T0.734410.664
10_E31_P0.734140.664
61_T65_V0.7330.663
51_A55_G0.727930.658
6_D37_Q0.722490.653
49_D52_R0.70810.640
11_I39_I0.706620.639
21_G57_K0.697440.630
52_R55_G0.686690.621
55_G59_V0.667370.603
17_R27_H0.656730.594
17_R29_E0.653250.590
6_D39_I0.652760.590
36_G64_Y0.650060.588
60_P66_A0.642370.581
64_Y68_Y0.639020.578
12_A43_L0.63650.575
15_T24_V0.626880.567
15_T29_E0.624280.564
26_T29_E0.614610.556
64_Y67_K0.6120.553
28_T68_Y0.600580.543
14_L25_I0.596490.539
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3frmA0.9872990.107
1tiqA0.9872990.108
4e2aA0.9872990.117
3fixA0.9872990.121
1u6mA0.987298.90.126
2q0yA0.987298.90.129
2pdoA0.987298.90.13
1r57A198.90.13
2i00A0.987298.90.135
3d2mA0.987298.90.136

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