GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
DUF4463 - Domain of unknown function (DUF4463)
Pfam: PF14703 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Length: 85
Sequences: 510
Seq/Len: 6
HH_delta: 0.886 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
80_E83_E0.389922.887
60_T71_V0.271612.011
61_G67_G0.25241.869
61_G64_G0.248431.839
73_A77_Y0.234241.734
2_C5_W0.225211.667
25_A73_A0.210341.557
14_E17_K0.204051.511
22_L74_I0.201991.496
2_C9_E0.199141.474
37_P41_P0.197451.462
60_T67_G0.194631.441
5_W18_A0.191481.418
9_E81_L0.190581.411
26_E78_R0.189621.404
42_K45_K0.179071.326
15_R85_N0.171171.267
63_L67_G0.16451.218
10_K13_E0.164251.216
81_L85_N0.163921.214
22_L72_D0.159361.180
35_K38_K0.154181.142
36_R40_R0.152891.132
2_C26_E0.150541.115
5_W9_E0.149761.109
17_K28_K0.149451.107
23_E30_L0.148491.099
8_L73_A0.148471.099
19_V81_L0.146761.087
19_V85_N0.144941.073
64_G67_G0.144341.069
79_E82_K0.142211.053
3_R85_N0.141031.044
10_K17_K0.139221.031
23_E70_K0.138931.029
29_Y33_A0.138381.025
22_L80_E0.138281.024
18_A77_Y0.137131.015
18_A81_L0.134420.995
14_E84_L0.133560.989
16_E24_S0.132390.980
79_E83_E0.130530.966
5_W81_L0.130080.963
14_E18_A0.129280.957
7_K13_E0.128270.950
10_K16_E0.128230.949
78_R82_K0.12330.913
12_V19_V0.122730.909
15_R25_A0.122680.908
28_K43_K0.122220.905
76_Y85_N0.122190.905
75_D82_K0.121970.903
25_A77_Y0.121660.901
26_E85_N0.119890.888
29_Y32_N0.119480.885
37_P40_R0.117380.869
40_R44_K0.116520.863
14_E80_E0.115230.853
62_F65_L0.115030.852
23_E27_S0.114440.847
7_K82_K0.114290.846
11_L61_G0.113840.843
13_E25_A0.11290.836
29_Y41_P0.112730.835
39_K42_K0.112410.832
6_S67_G0.111680.827
23_E74_I0.111040.822
31_K41_P0.109740.813
5_W8_L0.108550.804
27_S37_P0.108310.802
34_N76_Y0.108040.800
10_K29_Y0.107260.794
6_S27_S0.107250.794
29_Y72_D0.106950.792
26_E31_K0.10690.791
23_E81_L0.10650.789
37_P42_K0.105670.782
19_V23_E0.105410.780
28_K32_N0.10540.780
5_W20_R0.105230.779
32_N35_K0.104610.775
60_T69_K0.104110.771
76_Y80_E0.104040.770
18_A76_Y0.103670.768
35_K62_F0.099430.736
2_C15_R0.099370.736
17_K69_K0.098990.733
5_W12_V0.098520.729
12_V81_L0.09730.720
73_A78_R0.096940.718
36_R45_K0.09680.717
14_E31_K0.096670.716
3_R30_L0.095940.710
2_C73_A0.095840.710
74_I78_R0.094430.699
71_V83_E0.094130.697
1_I4_D0.093740.694
15_R26_E0.09360.693
33_A41_P0.093180.690
21_K25_A0.092980.688
12_V21_K0.092750.687
78_R85_N0.092090.682
38_K44_K0.091010.674
36_R62_F0.090830.673
44_K79_E0.090440.670
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
PDB Cov Prob HH_delta
3oa7A0.894114.60.886
2w6bA0.41189.80.894
2eqmA0.47068.70.896
1deqA0.67068.60.896
1zpyA0.52945.90.904
3k6cA0.52945.50.905
1fsuA0.67065.30.906
2ex3B0.98825.20.906
1l8dA0.835350.907
1m1jA0.68244.90.907
If you are interested in a protein containing this domain,
drop us a note and we'll try to predict the structure for you.

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