GREMLIN.BAKERLAB.org

Archive: 2012 - 2013
Tautomerase_3 - Putative oxalocrotonate tautomerase enzyme
Pfam: PF14832 (v27) Consensus Sequence
Download Alignment
(Note: includes all positions in family; we filtered this alignment to remove sites that had > 75% gaps before running GREMLIN. )
Clan: CL0082
Length: 136
Sequences: 1449
Seq/Len: 10.65
HH_delta: 0.073 (20Jul13)
GREMLIN Results:
Residue pairs sorted by strength in covariance:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] gremlin predictions, sequence seperation > 3. The i and j are positions as given in the consensus sequence. Show Scaled Distribution

ij Raw Score Scaled Score
6_I25_I0.412642.486
31_S85_R0.387122.332
7_Y44_I0.38532.321
83_L114_K0.365292.200
75_D78_Q0.349352.104
24_A93_H0.332342.002
84_D88_E0.323721.950
88_E92_P0.319131.922
87_D101_W0.317811.914
58_R100_D0.28621.724
83_L105_I0.275451.659
4_W25_I0.268471.617
7_Y42_R0.253921.530
76_D111_D0.251061.512
76_D80_R0.248951.500
27_D31_S0.247361.490
27_D89_V0.246981.488
79_R107_E0.244741.474
14_T17_Q0.243041.464
79_R112_L0.235021.416
27_D36_A0.233371.406
24_A89_V0.228171.374
22_A41_V0.227691.372
23_E27_D0.226751.366
81_R84_D0.209741.263
26_T36_A0.207761.252
5_Q65_V0.207471.250
18_K45_E0.20661.245
22_A52_F0.204691.233
18_K50_D0.203781.228
108_T112_L0.203071.223
85_R88_E0.200591.208
91_K98_G0.199311.201
81_R85_R0.199291.200
108_T113_W0.197611.190
26_T30_T0.196361.183
3_L42_R0.195461.177
4_W29_Y0.193791.167
5_Q42_R0.193341.165
65_V106_D0.193011.163
4_W64_I0.191471.153
24_A92_P0.189231.140
7_Y46_V0.185391.117
15_P77_E0.185381.117
19_Q52_F0.181731.095
22_A43_F0.179721.083
26_T41_V0.178621.076
88_E98_G0.175081.055
91_K95_A0.173281.044
85_R89_V0.173211.043
23_E56_K0.173171.043
6_I43_F0.172831.041
82_L86_I0.172051.036
20_A93_H0.169941.024
3_L113_W0.167321.008
43_F52_F0.166351.002
56_K84_D0.166331.002
52_F86_I0.165870.999
42_R49_G0.164690.992
63_R67_D0.163490.985
20_A24_A0.163440.985
76_D107_E0.161850.975
75_D79_R0.160250.965
16_E95_A0.15980.963
114_K117_G0.158150.953
27_D93_H0.157690.950
5_Q44_I0.15630.942
96_D99_Y0.155850.939
35_P38_Y0.155750.938
81_R88_E0.15510.934
27_D81_R0.15410.928
6_I90_L0.15290.921
78_Q81_R0.152440.918
45_E49_G0.152050.916
67_D106_D0.14920.899
39_V68_H0.146940.885
74_P79_R0.146720.884
56_K77_E0.145630.877
22_A25_I0.14550.876
31_S89_V0.14540.876
40_N102_E0.143570.865
38_Y102_E0.142850.861
23_E88_E0.142370.858
22_A32_I0.141050.850
80_R84_D0.140620.847
28_I89_V0.140080.844
33_G81_R0.139550.841
34_L102_E0.138970.837
104_H108_T0.138480.834
24_A94_T0.138110.832
107_E112_L0.137550.829
30_T36_A0.13670.823
102_E115_E0.136590.823
15_P19_Q0.136430.822
22_A38_Y0.135610.817
90_L98_G0.132810.800
96_D105_I0.130570.787
44_I116_N0.130420.786
10_P45_E0.130410.786
8_H43_F0.130180.784
38_Y115_E0.129770.782
9_P62_V0.129660.781
74_P78_Q0.129180.778
26_T39_V0.128810.776
30_T110_R0.128540.774
4_W62_V0.128380.773
14_T24_A0.128290.773
34_L115_E0.127650.769
87_D103_F0.127270.767
77_E81_R0.126380.761
22_A26_T0.125550.756
20_A58_R0.125490.756
89_V93_H0.125290.755
62_V94_T0.1250.753
51_F60_N0.124150.748
4_W113_W0.12370.745
51_F105_I0.123470.744
33_G85_R0.123320.743
26_T55_G0.123180.742
27_D30_T0.123010.741
21_L89_V0.122650.739
95_A101_W0.122280.737
21_L90_L0.121910.734
36_A56_K0.121350.731
79_R83_L0.121110.730
45_E110_R0.120770.728
10_P88_E0.119640.721
105_I113_W0.119590.720
96_D101_W0.119070.717
64_I103_F0.119040.717
28_I85_R0.118850.716
10_P94_T0.118810.716
15_P20_A0.11870.715
35_P100_D0.118680.715
40_N113_W0.117990.711
14_T92_P0.117320.707
42_R51_F0.116970.705
18_K43_F0.116940.704
79_R105_I0.116490.702
59_D97_K0.116490.702
24_A28_I0.116480.702
56_K59_D0.115750.697
67_D104_H0.115650.697
14_T88_E0.115630.697
17_Q60_N0.115560.696
42_R116_N0.115450.695
16_E98_G0.115040.693
10_P25_I0.114230.688
83_L103_F0.1140.687
34_L41_V0.113980.687
60_N100_D0.113470.684
37_F41_V0.113180.682
26_T29_Y0.112290.676
4_W105_I0.112240.676
77_E99_Y0.112130.675
16_E19_Q0.111930.674
53_V96_D0.111690.673
81_R92_P0.111580.672
41_V94_T0.110470.665
91_K94_T0.110360.665
5_Q67_D0.110340.665
Legend: The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction. These are to be used for relative ranking only.
HHsearch Results:
Top (length/2) GREMLIN results overlayed on top 10 PDB hits:

Legend: The grey circles underneath are pdb residue contacts (min distance < 5 Angstroms). The coloring of these circles is based on HHsearch results which uses the overall probability, per-site alignment prob and agreement of top hits weighted by HHsearch score (Note we only consider monomeric contacts, there might be homo-oligomeric contacts in the pdb that are not shown.)
PDB Cov Prob HH_delta
3c6vA199.90.073
3n4hA0.963299.90.24
3mf7A0.963299.90.243
3t5sA0.830999.80.297
2aalA0.919199.80.298
1uizA0.838299.80.307
2os5A0.867699.80.31
2xczA0.838299.80.31
3fwtA0.823599.80.319
3fwuA0.823599.80.319

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