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hsp90a

ID: 1506723228 Query Sequence

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 737 (667)
Sequences: 2537 (1263.3)
Seq/Len: 3.804
Nf(neff/√len): 48.9

HHblits Results: (2016_02)
Sequences per length for each position, BEFORE the coverage/gap filter was applied

Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 3.804).

Sequences per length for each position, AFTER the coverage/gap filter was applied
Legend: If visible, the positions blocked in grey are regions that have > 75% gaps and were automatically trimmed and excluded in the GREMLIN analysis.

Trim query Generate MSA using: Filter MSA GREMLIN
Start: End: E-value: Iterations: Coverage: Remove gaps: Prior:

GREMLIN Results:
Residue pairs sorted by coevolution strength:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.

ij Scaled score Prob
156_I192_I4.7861.00
501_G507_V4.6091.00
315_G327_D4.4761.00
97_V190_K4.3401.00
112_L155_V4.3061.00
488_R522_E3.7711.00
580_M668_V3.6631.00
201_E207_R3.6471.00
88_N91_D3.5281.00
92_R200_T3.4971.00
152_K168_E3.4831.00
435_D438_N3.4141.00
474_A520_G3.3341.00
89_K204_E3.1701.00
85_L212_V3.1671.00
673_E692_R3.1521.00
154_T168_E3.1351.00
571_T574_E3.1101.00
581_K590_K3.0431.00
465_S538_L3.0351.00
483_K541_F3.0341.00
574_E578_K3.0331.00
473_S522_E2.9941.00
104_T159_H2.9571.00
107_D159_H2.8551.00
580_M641_I2.8381.00
484_D487_T2.8301.00
156_I166_A2.8281.00
504_K508_A2.8131.00
151_E194_H2.8111.00
309_I313_E2.7741.00
108_L157_T2.7581.00
319_K327_D2.7061.00
209_K293_E2.6061.00
82_H224_T2.6051.00
106_A110_N2.5831.00
473_S525_Y2.5651.00
205_E209_K2.5601.00
61_L81_L2.5401.00
472_T524_I2.5171.00
54_I212_V2.4921.00
154_T194_H2.4831.00
207_R210_E2.4821.00
540_E543_G2.4611.00
166_A178_R2.4321.00
67_E159_H2.3491.00
156_I190_K2.3481.00
588_V591_V2.3431.00
122_A125_E2.3241.00
23_E105_K2.3051.00
311_N331_V2.2931.00
394_V421_L2.2901.00
84_N292_Q2.2881.00
233_K287_E2.2321.00
666_D695_R2.2091.00
228_E288_K2.1981.00
212_V295_L2.1941.00
231_R289_Y2.1871.00
578_K582_D2.1731.00
567_E571_T2.1501.00
86_I97_V2.1091.00
350_R441_K2.0841.00
152_K194_H2.0821.00
516_L549_V2.0601.00
226_F292_Q1.9951.00
164_Q179_T1.9871.00
310_T313_E1.9731.00
535_V546_L1.9661.00
47_E207_R1.9421.00
120_T135_M1.9321.00
150_A193_L1.9261.00
163_E179_T1.9221.00
589_E607_S1.9211.00
351_R445_Q1.9201.00
441_K444_E1.8811.00
301_I309_I1.8541.00
146_A153_V1.8541.00
47_E202_Y1.8521.00
326_E351_R1.8461.00
61_L221_Y1.8431.00
156_I180_D1.8180.99
602_C671_L1.8170.99
117_K122_A1.8160.99
152_K170_S1.7960.99
87_P208_I1.7790.99
482_L542_E1.7550.99
311_N315_G1.7480.99
390_I425_C1.7470.99
93_T192_I1.7350.99
587_K669_I1.7350.99
473_S488_R1.7280.99
490_K520_G1.7270.99
466_E483_K1.7240.99
224_T294_E1.7230.99
154_T166_A1.7160.99
230_E286_K1.7050.99
508_A525_Y1.6960.99
230_E288_K1.6930.99
568_E572_K1.6800.99
513_V549_V1.6770.99
33_Q121_K1.6730.99
46_K199_Q1.6550.99
596_R605_V1.6530.99
84_N97_V1.6250.99
315_G331_V1.6240.99
96_I191_V1.6210.99
157_T175_F1.6100.98
582_D585_E1.6100.98
108_L112_L1.6100.98
466_E542_E1.6010.98
470_Y526_M1.5840.98
314_Y347_F1.5840.98
84_N224_T1.5790.98
567_E570_K1.5760.98
154_T192_I1.5750.98
614_N617_R1.5640.98
168_E176_T1.5510.98
122_A126_A1.5500.98
685_D688_T1.5390.98
304_R313_E1.5280.98
232_D284_K1.5260.98
568_E571_T1.5140.97
224_T292_Q1.4930.97
39_I48_I1.4900.97
616_E637_K1.4870.97
583_I668_V1.4850.97
315_G328_H1.4800.97
579_I664_V1.4790.97
50_L96_I1.4730.97
226_F290_I1.4690.97
474_A490_K1.4670.97
228_E290_I1.4670.97
89_K203_L1.4660.97
229_K289_Y1.4570.97
22_V178_R1.4560.97
53_L193_L1.4480.96
110_N122_A1.4450.96
650_T654_K1.4440.96
466_E541_F1.4360.96
478_E482_L1.4340.96
146_A193_L1.4320.96
495_H547_V1.4290.96
327_D350_R1.4170.96
400_P411_S1.4150.96
581_K585_E1.4100.96
387_L426_L1.4020.96
105_K109_I1.4010.96
352_A445_Q1.3960.95
514_E600_S1.3880.95
478_E481_S1.3760.95
321_L325_W1.3750.95
95_T190_K1.3690.95
229_K293_E1.3670.95
494_K558_E1.3570.94
316_E319_K1.3570.94
85_L295_L1.3520.94
643_P646_S1.3430.94
85_L208_I1.3410.94
85_L94_L1.3350.94
64_I160_N1.3340.94
669_I692_R1.3280.94
489_M544_K1.3240.93
432_L480_V1.3240.93
483_K542_E1.3180.93
479_M482_L1.3180.93
575_N578_K1.3120.93
646_S649_E1.3080.93
495_H545_T1.3060.93
486_C542_E1.3060.93
503_T506_Q1.3050.93
469_R481_S1.3030.93
508_A517_R1.2950.92
312_E316_E1.2910.92
49_F149_V1.2810.92
64_I187_R1.2810.92
641_I648_I1.2800.92
209_K227_V1.2800.92
437_E441_K1.2730.92
363_K380_E1.2670.91
42_F403_I1.2650.91
589_E636_K1.2610.91
67_E71_D1.2520.91
388_N452_L1.2490.90
209_K225_L1.2480.90
540_E545_T1.2450.90
666_D692_R1.2450.90
81_L187_R1.2440.90
208_I212_V1.2430.90
314_Y333_H1.2410.90
383_I421_L1.2410.90
479_M488_R1.2390.90
108_L155_V1.2390.90
518_K598_V1.2370.90
516_L554_L1.2340.90
25_F175_F1.2320.90
672_Y676_L1.2270.89
305_N308_D1.2250.89
454_I534_C1.2200.89
233_K285_I1.2200.89
559_D562_E1.2110.89
649_E653_Q1.2060.88
107_D110_N1.2050.88
47_E214_K1.2010.88
205_E227_V1.1900.87
44_S407_M1.1860.87
472_T488_R1.1850.87
168_E178_R1.1840.87
227_V293_E1.1830.87
232_D286_K1.1830.87
691_N695_R1.1780.87
232_D235_V1.1770.87
472_T480_V1.1770.87
648_I671_L1.1760.87
665_K669_I1.1740.86
587_K684_E1.1730.86
569_K644_D1.1660.86
690_A694_Y1.1660.86
334_F344_A1.1590.85
450_I464_L1.1580.85
233_K282_K1.1540.85
596_R640_E1.1500.85
563_K567_E1.1480.85
439_Y467_L1.1420.84
24_T176_T1.1420.84
231_R287_E1.1410.84
312_E315_G1.1390.84
164_Q180_D1.1360.84
235_V282_K1.1330.84
570_K574_E1.1290.83
309_I333_H1.1280.83
532_E612_T1.1230.83
61_L99_T1.1190.83
237_D240_A1.1180.83
579_I583_I1.1180.83
331_V347_F1.1180.83
104_T107_D1.1170.82
572_K652_R1.1160.82
662_K665_K1.1140.82
479_M522_E1.1100.82
689_H693_I1.1080.82
592_V638_H1.1050.82
670_L689_H1.1030.81
128_Q131_A1.1030.81
105_K179_T1.1010.81
577_C593_V1.0960.81
110_N117_K1.0930.81
121_K125_E1.0860.80
494_K545_T1.0820.80
306_P309_I1.0810.80
112_L177_V1.0780.79
103_M108_L1.0780.79
439_Y443_Y1.0770.79
334_F424_K1.0770.79
53_L146_A1.0760.79
69_L72_P1.0760.79
87_P94_L1.0750.79
463_K466_E1.0750.79
326_E350_R1.0740.79
462_K542_E1.0710.79
669_I673_E1.0700.79
86_I94_L1.0630.78
96_I193_L1.0590.78
615_M619_M1.0590.78
457_D460_N1.0590.78
25_F105_K1.0590.78
454_I468_L1.0570.77
78_G187_R1.0480.77
513_V523_V1.0450.76
586_K636_K1.0440.76
518_K599_T1.0420.76
212_V577_C1.0420.76
204_E207_R1.0400.76
573_F652_R1.0400.76
348_V390_I1.0400.76
436_K484_D1.0330.75
84_N226_F1.0310.75
329_L438_N1.0290.75
232_D283_K1.0270.75
86_I95_T1.0260.74
236_S281_K1.0250.74
480_V524_I1.0220.74
68_S74_K1.0220.74
649_E652_R1.0220.74
337_E341_E1.0200.74
447_S451_K1.0190.74
235_V284_K1.0180.74
471_Y504_K1.0170.73
371_R396_S1.0120.73
46_K196_K1.0120.73
486_C489_M1.0110.73
114_T117_K1.0100.73
303_T343_R1.0100.73
111_N117_K1.0090.73
229_K291_D1.0080.73
166_A192_I1.0040.72
489_M493_Q1.0030.72
483_K486_C1.0030.72
107_D111_N1.0020.72
374_F383_I1.0010.72
Legend: Only predictions with Scaled Score > 1 are listed. For all 3L/2 predictions, click on one of the links below.
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
NEW Features
HHsearch Results: (06Aug15)
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
PDB M Cov P(%) HHΔ  
2cg9A20.83581000.205Contact Map
2o1uA20.77751000.257Contact Map
2ioqA20.78971000.276Contact Map
4ivgA10.63231000.303Contact Map
4ipeA20.81141000.307Contact Map
1y4sA20.63641000.334Contact Map
3q6mA30.50881000.46Contact Map
3hjcA10.52511000.475Contact Map
2cgeA30.54821000.484Contact Map
1hk7A20.34741000.609Contact Map
M = number of chains, if homo-oligomer
Cov = coverage of hit
P(%) = probability

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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